Adenovirus-mediated herpes simplex virus thymidine kinase/ganciclovir gene therapy in patients with localized malignancy: results of a phase I clinical trial in malignant mesothelioma

Malignant pleural mesothelioma is a fatal neoplasm that is unresponsive to standard modalities of cancer therapy. We conducted a phase I dose-escalation clinical trial of adenoviral (Ad)-mediated intrapleural herpes simplex virus thymidine kinase (HSVtk)/ganciclovir (GCV) gene therapy in patients wi...

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Veröffentlicht in:	Human gene therapy 1998-05, Vol.9 (7), p.1083-1092
Hauptverfasser:	Sterman, D H, Treat, J, Litzky, L A, Amin, K M, Coonrod, L, Molnar-Kimber, K, Recio, A, Knox, L, Wilson, J M, Albelda, S M, Kaiser, L R
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviruses, Human - metabolism Adult Aged Antiviral Agents - pharmacology Antiviral Agents - toxicity Female Ganciclovir - pharmacology Ganciclovir - toxicity Gene Transfer Techniques Genetic Therapy - methods Genetic Vectors Humans Male Mesothelioma - pathology Mesothelioma - therapy Middle Aged Simplexvirus - enzymology Simplexvirus - genetics Survivors Thymidine Kinase - genetics
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