Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation

The premutagenic oxidative DNA base damage, 7,8-dihydro-8-oxoguanine, is induced in human skin fibroblasts by monochromatic radiation ranging from a UVB wavelength (312 nm) up to wavelengths in the near visible (434 nm). The oxidative damage is not generated by absorption of radiation in DNA but rat...

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Veröffentlicht in:	Carcinogenesis (New York) 1997-12, Vol.18 (12), p.2379-2384
Hauptverfasser:	KVAM, E, TYRRELL, R. M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens Cells, Cultured Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DNA Damage - radiation effects Dose-Response Relationship, Radiation Fibroblasts Humans Medical sciences Melanoma - pathology Oxidation-Reduction Physical agents Pyrimidine Dimers Skin - radiation effects Skin Neoplasms - pathology Spectrum Analysis Tumors Ultraviolet Rays
Online-Zugang:	Volltext
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