Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei Province, China
Specific human leucocyte antigen (HLA) alleles are considered a genetic risk factor for the progression of haemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses. The aim of this study was to establish whether HLA-DRB alleles are associated with the severity of HFRS caused by different...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2015-01, Vol.34 (1), p.187-195 |
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| creator | Zhu, N. Luo, F. Chen, Q. Li, N. Xiong, H. Feng, Y. Yang, Z. Hou, W. |
| description | Specific human leucocyte antigen (HLA) alleles are considered a genetic risk factor for the progression of haemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses. The aim of this study was to establish whether HLA-DRB alleles are associated with the severity of HFRS caused by different types of hantaviruses in a Chinese Han population from Hubei Province of central China. Twenty-two specific HLA-DRB alleles were analysed by sequence-specific primer–polymerase chain reaction (SSP-PCR) in 100 HFRS patients and 213 healthy volunteers. Associations of HLA-DRB alleles with the severity and clinical parameters of HFRS caused by Hantaan virus (HTNV) or Seoul virus (SEOV) infection were evaluated. Six alleles (HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202, HLA-DRB1*1305 and DRB5*0101-0201) demonstrated strong associations with HFRS caused by HTNV and SEOV infections. Further comparison of these HLA-DRB1 allele frequencies between HFRS patients with differing severities and healthy controls demonstrated that the HLA-DRB1*0401-0411, HLA-DRB1*1001 and DRB1*1305 alleles were more frequent in the moderate course of HTNV-infected HFRS. Meanwhile, the DRB1*1101-1105 allele was more frequently observed in the severe course of HTNV-infected HFRS. We also found that the HLA-DRB1*1201-1202 allele frequency was higher in the moderate course of SEOV-infected HFRS, whereas the DRB5*0101-0201 allele may play a protective role in moderate HFRS caused by both HTNV and SEOV infections. These results provide evidence of the influence of HLA-DRB on the severity of HFRS and confirm the effect of HLA-DRB on HFRS during different types of hantavirus infection in a Chinese Han population in Hubei Province, China. |
| doi_str_mv | 10.1007/s10096-014-2213-9 |
| format | Article |
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The aim of this study was to establish whether HLA-DRB alleles are associated with the severity of HFRS caused by different types of hantaviruses in a Chinese Han population from Hubei Province of central China. Twenty-two specific HLA-DRB alleles were analysed by sequence-specific primer–polymerase chain reaction (SSP-PCR) in 100 HFRS patients and 213 healthy volunteers. Associations of HLA-DRB alleles with the severity and clinical parameters of HFRS caused by Hantaan virus (HTNV) or Seoul virus (SEOV) infection were evaluated. Six alleles (HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202, HLA-DRB1*1305 and DRB5*0101-0201) demonstrated strong associations with HFRS caused by HTNV and SEOV infections. Further comparison of these HLA-DRB1 allele frequencies between HFRS patients with differing severities and healthy controls demonstrated that the HLA-DRB1*0401-0411, HLA-DRB1*1001 and DRB1*1305 alleles were more frequent in the moderate course of HTNV-infected HFRS. Meanwhile, the DRB1*1101-1105 allele was more frequently observed in the severe course of HTNV-infected HFRS. We also found that the HLA-DRB1*1201-1202 allele frequency was higher in the moderate course of SEOV-infected HFRS, whereas the DRB5*0101-0201 allele may play a protective role in moderate HFRS caused by both HTNV and SEOV infections. These results provide evidence of the influence of HLA-DRB on the severity of HFRS and confirm the effect of HLA-DRB on HFRS during different types of hantavirus infection in a Chinese Han population in Hubei Province, China.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-014-2213-9</identifier><identifier>PMID: 25169964</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adult ; Aged ; Alleles ; Antigens ; Biomedical and Life Sciences ; Biomedicine ; China ; Disease ; Disease Susceptibility ; Female ; Fever ; Gene Frequency ; Hantaan virus - immunology ; Hantaan virus - isolation & purification ; Hantavirus ; Health care ; Hemorrhagic Fever with Renal Syndrome - genetics ; Hemorrhagic Fever with Renal Syndrome - pathology ; HLA-DR beta-Chains - genetics ; Humans ; Infections ; Internal Medicine ; Laboratories ; Leukocytes ; Male ; Medical Microbiology ; Middle Aged ; Patients ; Polymerase Chain Reaction ; Risk factors ; Seoul virus - immunology ; Seoul virus - isolation & purification ; Severity of Illness Index ; Virology ; Young Adult</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2015-01, Vol.34 (1), p.187-195</ispartof><rights>Springer-Verlag Berlin Heidelberg 2014</rights><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-18673283fe9097bebe135b0d41fd7f8966885939ae45e7cd5c98a8ea1ba08223</citedby><cites>FETCH-LOGICAL-c442t-18673283fe9097bebe135b0d41fd7f8966885939ae45e7cd5c98a8ea1ba08223</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-014-2213-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-014-2213-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25169964$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, N.</creatorcontrib><creatorcontrib>Luo, F.</creatorcontrib><creatorcontrib>Chen, Q.</creatorcontrib><creatorcontrib>Li, N.</creatorcontrib><creatorcontrib>Xiong, H.</creatorcontrib><creatorcontrib>Feng, Y.</creatorcontrib><creatorcontrib>Yang, Z.</creatorcontrib><creatorcontrib>Hou, W.</creatorcontrib><title>Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei Province, China</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Specific human leucocyte antigen (HLA) alleles are considered a genetic risk factor for the progression of haemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses. The aim of this study was to establish whether HLA-DRB alleles are associated with the severity of HFRS caused by different types of hantaviruses in a Chinese Han population from Hubei Province of central China. Twenty-two specific HLA-DRB alleles were analysed by sequence-specific primer–polymerase chain reaction (SSP-PCR) in 100 HFRS patients and 213 healthy volunteers. Associations of HLA-DRB alleles with the severity and clinical parameters of HFRS caused by Hantaan virus (HTNV) or Seoul virus (SEOV) infection were evaluated. Six alleles (HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202, HLA-DRB1*1305 and DRB5*0101-0201) demonstrated strong associations with HFRS caused by HTNV and SEOV infections. Further comparison of these HLA-DRB1 allele frequencies between HFRS patients with differing severities and healthy controls demonstrated that the HLA-DRB1*0401-0411, HLA-DRB1*1001 and DRB1*1305 alleles were more frequent in the moderate course of HTNV-infected HFRS. Meanwhile, the DRB1*1101-1105 allele was more frequently observed in the severe course of HTNV-infected HFRS. We also found that the HLA-DRB1*1201-1202 allele frequency was higher in the moderate course of SEOV-infected HFRS, whereas the DRB5*0101-0201 allele may play a protective role in moderate HFRS caused by both HTNV and SEOV infections. These results provide evidence of the influence of HLA-DRB on the severity of HFRS and confirm the effect of HLA-DRB on HFRS during different types of hantavirus infection in a Chinese Han population in Hubei Province, China.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Antigens</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>China</subject><subject>Disease</subject><subject>Disease Susceptibility</subject><subject>Female</subject><subject>Fever</subject><subject>Gene Frequency</subject><subject>Hantaan virus - immunology</subject><subject>Hantaan virus - isolation & purification</subject><subject>Hantavirus</subject><subject>Health care</subject><subject>Hemorrhagic Fever with Renal Syndrome - genetics</subject><subject>Hemorrhagic Fever with Renal Syndrome - pathology</subject><subject>HLA-DR beta-Chains - genetics</subject><subject>Humans</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Laboratories</subject><subject>Leukocytes</subject><subject>Male</subject><subject>Medical Microbiology</subject><subject>Middle Aged</subject><subject>Patients</subject><subject>Polymerase Chain Reaction</subject><subject>Risk factors</subject><subject>Seoul virus - immunology</subject><subject>Seoul virus - isolation & purification</subject><subject>Severity of Illness Index</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kV1rFDEUhoNY7Fr9Ad5IwBsvTM3XTJLLun5sYUGR3ofMzJluSiZZk51K8c-bdaqUgjfJxXne93B4EHrF6DmjVL0v9TUtoUwSzpkg5glaMSkaIoUST9GKGiGJUVycouel3NCa0Uo9Q6e8Ya0xrVyhX5dxDDPEHnAa8WZ7QT5-_4BdCBCg4BTxzsGUct65a9_jEW4h45_-sMMZogu43MUhpwmwj9jh9c5HKIA3LuJ92s_BHXytqLPN3IHH33K69XXVuz-ke4FORhcKvLz_z9DV509X6w3Zfv1yub7Ykl5KfiBMt0pwLUYw1KgOOmCi6egg2TioUZu21boxwjiQDah-aHqjnQbHOkc15-IMvV1q9zn9mKEc7ORLDyG4CGkulrWS6aYVWlT0zSP0Js25HrpQTBkmj4VsofqcSskw2n32k8t3llF7FGMXMbaKsUcx1tTM6_vmuZtg-Jf4a6ICfAFKHcVryA9W_7f1NwQdl1M</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Zhu, N.</creator><creator>Luo, F.</creator><creator>Chen, Q.</creator><creator>Li, N.</creator><creator>Xiong, H.</creator><creator>Feng, Y.</creator><creator>Yang, Z.</creator><creator>Hou, W.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei Province, China</title><author>Zhu, N. ; Luo, F. ; Chen, Q. ; Li, N. ; Xiong, H. ; Feng, Y. ; Yang, Z. ; Hou, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-18673283fe9097bebe135b0d41fd7f8966885939ae45e7cd5c98a8ea1ba08223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Antigens</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>China</topic><topic>Disease</topic><topic>Disease Susceptibility</topic><topic>Female</topic><topic>Fever</topic><topic>Gene Frequency</topic><topic>Hantaan virus - immunology</topic><topic>Hantaan virus - isolation & purification</topic><topic>Hantavirus</topic><topic>Health care</topic><topic>Hemorrhagic Fever with Renal Syndrome - genetics</topic><topic>Hemorrhagic Fever with Renal Syndrome - pathology</topic><topic>HLA-DR beta-Chains - genetics</topic><topic>Humans</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Laboratories</topic><topic>Leukocytes</topic><topic>Male</topic><topic>Medical Microbiology</topic><topic>Middle Aged</topic><topic>Patients</topic><topic>Polymerase Chain Reaction</topic><topic>Risk factors</topic><topic>Seoul virus - immunology</topic><topic>Seoul virus - isolation & purification</topic><topic>Severity of Illness Index</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, N.</creatorcontrib><creatorcontrib>Luo, F.</creatorcontrib><creatorcontrib>Chen, Q.</creatorcontrib><creatorcontrib>Li, N.</creatorcontrib><creatorcontrib>Xiong, H.</creatorcontrib><creatorcontrib>Feng, Y.</creatorcontrib><creatorcontrib>Yang, Z.</creatorcontrib><creatorcontrib>Hou, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, N.</au><au>Luo, F.</au><au>Chen, Q.</au><au>Li, N.</au><au>Xiong, H.</au><au>Feng, Y.</au><au>Yang, Z.</au><au>Hou, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei Province, China</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>34</volume><issue>1</issue><spage>187</spage><epage>195</epage><pages>187-195</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Specific human leucocyte antigen (HLA) alleles are considered a genetic risk factor for the progression of haemorrhagic fever with renal syndrome (HFRS) caused by hantaviruses. The aim of this study was to establish whether HLA-DRB alleles are associated with the severity of HFRS caused by different types of hantaviruses in a Chinese Han population from Hubei Province of central China. Twenty-two specific HLA-DRB alleles were analysed by sequence-specific primer–polymerase chain reaction (SSP-PCR) in 100 HFRS patients and 213 healthy volunteers. Associations of HLA-DRB alleles with the severity and clinical parameters of HFRS caused by Hantaan virus (HTNV) or Seoul virus (SEOV) infection were evaluated. Six alleles (HLA-DRB1*0401-0411, HLA-DRB1*1001, HLA-DRB1*1101-1105, HLA-DRB1*1201-1202, HLA-DRB1*1305 and DRB5*0101-0201) demonstrated strong associations with HFRS caused by HTNV and SEOV infections. Further comparison of these HLA-DRB1 allele frequencies between HFRS patients with differing severities and healthy controls demonstrated that the HLA-DRB1*0401-0411, HLA-DRB1*1001 and DRB1*1305 alleles were more frequent in the moderate course of HTNV-infected HFRS. Meanwhile, the DRB1*1101-1105 allele was more frequently observed in the severe course of HTNV-infected HFRS. We also found that the HLA-DRB1*1201-1202 allele frequency was higher in the moderate course of SEOV-infected HFRS, whereas the DRB5*0101-0201 allele may play a protective role in moderate HFRS caused by both HTNV and SEOV infections. These results provide evidence of the influence of HLA-DRB on the severity of HFRS and confirm the effect of HLA-DRB on HFRS during different types of hantavirus infection in a Chinese Han population in Hubei Province, China.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25169964</pmid><doi>10.1007/s10096-014-2213-9</doi><tpages>9</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Alleles Antigens Biomedical and Life Sciences Biomedicine China Disease Disease Susceptibility Female Fever Gene Frequency Hantaan virus - immunology Hantaan virus - isolation & purification Hantavirus Health care Hemorrhagic Fever with Renal Syndrome - genetics Hemorrhagic Fever with Renal Syndrome - pathology HLA-DR beta-Chains - genetics Humans Infections Internal Medicine Laboratories Leukocytes Male Medical Microbiology Middle Aged Patients Polymerase Chain Reaction Risk factors Seoul virus - immunology Seoul virus - isolation & purification Severity of Illness Index Virology Young Adult |
| title | Influence of HLA-DRB alleles on haemorrhagic fever with renal syndrome in a Chinese Han population in Hubei Province, China |
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