Oligomerization of Endogenous and Synthetic Amyloid β-Protein at Nanomolar Levels in Cell Culture and Stabilization of Monomer by Congo Red

Amyloid β-proteins (Aβ) are proteolytic fragments of the β-amyloid precursor protein (βAPP) that are secreted by mammalian cells throughout life but also accumulate progressively as insoluble cerebral aggregates in Alzheimer's disease (AD). Because mounting evidence indicates that Aβ aggregatio...

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Veröffentlicht in:Biochemistry (Easton) 1998-03, Vol.37 (11), p.3602-3611
Hauptverfasser: Podlisny, Marcia B, Walsh, Dominic M, Amarante, Patricia, Ostaszewski, Beth L, Stimson, Evelyn R, Maggio, John E, Teplow, David B, Selkoe, Dennis J
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Sprache:eng
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