Hyperbaric oxygen preconditioning protects lung against hyperoxic acute lung injury in rats via heme oxygenase-1 induction

•HBO-PC ameliorated the biochemical and histological lung alterations induced by hyperoxia.•HBO-PC decreased oxidative products but increased antioxidant enzymes.•HBO-PC up-regulated HO-1 mRNA and activity.•HO-1 inhibitor abolished the protective effects of HBO-PC. Hyperoxic acute lung injury (HALI)...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-01, Vol.456 (2), p.549-554
Hauptverfasser:	Feng, Ying, Zhang, Zinan, Li, Qiang, Li, Weihao, Xu, Jing, Cao, Huifang
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - pathology Acute Lung Injury - prevention & control Animals Enzyme Inhibitors - administration & dosage Heme Oxygenase (Decyclizing) - antagonists & inhibitors Heme Oxygenase (Decyclizing) - biosynthesis Heme oxygenase-1 Hyperbaric oxygen preconditioning Hyperbaric Oxygenation - methods Hyperoxia - pathology Hyperoxia - prevention & control Hyperoxic acute lung injury L-Lactate Dehydrogenase - metabolism Male Oxidative stress Protoporphyrins - administration & dosage Rats Rats, Sprague-Dawley Ventilator-Induced Lung Injury - pathology Ventilator-Induced Lung Injury - prevention & control
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