RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells

The nuclear hormone receptor retinoic acid-related orphan receptor gamma t (RORγt) is a transcription factor (TF) specific to TH17 cells that produce interleukin (IL)-17 and have been implicated in a wide range of autoimmunity. Here, we developed a novel therapeutic strategy to modulate the function...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-12, Vol.111 (52), p.18673-18678
Hauptverfasser:	Park, Tae-Yoon, Park, Sung-Dong, Cho, Jen-Young, Moon, Jae-Seung, Kim, Na-Yeon, Park, Kyungsoo, Seong, Rho Hyun, Lee, Sang-Won, Morio, Tomohiro, Bothwell, Alfred L. M., Lee, Sang-Kyou
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - pathology Arthritis, Rheumatoid - therapy Autoimmune diseases Autoimmunity Biological Sciences CD4-positive T-lymphocytes Cell Differentiation - genetics Cell Differentiation - immunology Cell Nucleus - immunology Cell Nucleus - pathology Cellular differentiation Cytokines DNA-binding domains Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Encephalomyelitis, Autoimmune, Experimental - therapy HEK293 Cells HeLa Cells Humans interleukin-17 Medical treatment Mice Nuclear Receptor Subfamily 1, Group F, Member 3 - antagonists & inhibitors Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics Nuclear Receptor Subfamily 1, Group F, Member 3 - immunology Secretion sequence analysis Spinal cord Spinal Cord - immunology Spinal Cord - pathology T lymphocytes Th1 Cells - immunology Th1 Cells - pathology Th17 Cells - immunology Th17 Cells - pathology therapeutics transcription (genetics) Transcription factors
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