Ventilatory efficiency before and after lung volume reduction surgery
Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (V̇E) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (V̇E/V̇CO2 ). We compared 55 LVRS subjects with 25 controls from the National Emphys...
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| Veröffentlicht in: | Respiratory care 2015-01, Vol.60 (1), p.63-71 |
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| creator | Armstrong, Hilary F Dussault, Nicole E Thirapatarapong, Wilawan Lemieux, Renee S Thomashow, Byron M Bartels, Matthew N |
| description | Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (V̇E) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (V̇E/V̇CO2 ).
We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. V̇E/V̇CO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess V̇E/V̇CO2 changes with LVRS compared with controls who only received standard medical care.
At 6 months, the LVRS group significantly increased peak V̇O2 , work load, V̇E, V̇CO2 , and tidal volume while lowering peak and lowest V̇E/V̇CO2 (improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W).
The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome. |
| doi_str_mv | 10.4187/respcare.03233 |
| format | Article |
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We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. V̇E/V̇CO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess V̇E/V̇CO2 changes with LVRS compared with controls who only received standard medical care.
At 6 months, the LVRS group significantly increased peak V̇O2 , work load, V̇E, V̇CO2 , and tidal volume while lowering peak and lowest V̇E/V̇CO2 (improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W).
The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.</description><identifier>ISSN: 0020-1324</identifier><identifier>EISSN: 1943-3654</identifier><identifier>DOI: 10.4187/respcare.03233</identifier><identifier>PMID: 25371397</identifier><language>eng</language><publisher>United States: Daedalus Enterprises, Inc</publisher><subject>Aged ; Carbon Dioxide ; Care and treatment ; Exercise Test ; Exercise Tolerance - physiology ; Female ; Forced Expiratory Volume ; Health aspects ; Humans ; Lung diseases, Obstructive ; Lungs ; Male ; Middle Aged ; Oxygen Consumption ; Patient outcomes ; Physical Exertion - physiology ; Pneumonectomy ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - surgery ; Pulmonary gas exchange ; Pulmonary Gas Exchange - physiology ; Pulmonary Ventilation - physiology ; Residual Volume ; Retrospective Studies ; Surgery ; Tidal Volume ; Vital Capacity</subject><ispartof>Respiratory care, 2015-01, Vol.60 (1), p.63-71</ispartof><rights>Copyright © 2015 by Daedalus Enterprises.</rights><rights>COPYRIGHT 2015 Daedalus Enterprises, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-c83e4a26aaf93a29453654536cf30af840755e5320cc03e6fdd2e34dedff5e543</citedby><cites>FETCH-LOGICAL-c394t-c83e4a26aaf93a29453654536cf30af840755e5320cc03e6fdd2e34dedff5e543</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25371397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Armstrong, Hilary F</creatorcontrib><creatorcontrib>Dussault, Nicole E</creatorcontrib><creatorcontrib>Thirapatarapong, Wilawan</creatorcontrib><creatorcontrib>Lemieux, Renee S</creatorcontrib><creatorcontrib>Thomashow, Byron M</creatorcontrib><creatorcontrib>Bartels, Matthew N</creatorcontrib><title>Ventilatory efficiency before and after lung volume reduction surgery</title><title>Respiratory care</title><addtitle>Respir Care</addtitle><description>Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (V̇E) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (V̇E/V̇CO2 ).
We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. V̇E/V̇CO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess V̇E/V̇CO2 changes with LVRS compared with controls who only received standard medical care.
At 6 months, the LVRS group significantly increased peak V̇O2 , work load, V̇E, V̇CO2 , and tidal volume while lowering peak and lowest V̇E/V̇CO2 (improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W).
The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.</description><subject>Aged</subject><subject>Carbon Dioxide</subject><subject>Care and treatment</subject><subject>Exercise Test</subject><subject>Exercise Tolerance - physiology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Lung diseases, Obstructive</subject><subject>Lungs</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Oxygen Consumption</subject><subject>Patient outcomes</subject><subject>Physical Exertion - physiology</subject><subject>Pneumonectomy</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - surgery</subject><subject>Pulmonary gas exchange</subject><subject>Pulmonary Gas Exchange - physiology</subject><subject>Pulmonary Ventilation - physiology</subject><subject>Residual Volume</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Tidal Volume</subject><subject>Vital Capacity</subject><issn>0020-1324</issn><issn>1943-3654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkd9LwzAQx4Mobk5ffZSCIL50JrmkXR_HmD9g4Iv6GrL0slXaZiat0P_e1k3Rlzvu-Nxx3_sScsnoVLBZeucx7Iz2OKXAAY7ImGUCYkikOCZjSjmNGXAxImchvPdlImR2SkZcQsogS8dk-YZ1U5S6cb6L0NrCFFibLlqjdR4jXeeRtg36qGzrTfTpyrbCyGPemqZwdRRav0HfnZMTq8uAF4c8Ia_3y5fFY7x6fnhazFexgUw0sZkBCs0TrW0GmmdCDof2wVig2s4ETaVECZwaQwETm-ccQeSYW9v3BUzI7X7vzruPFkOjqiIYLEtdo2uDYolggieUJT16vUc3ukRV1NY1XpsBV_NeOU_kDGRP3fyhtqjLZht6kYO48B-c7kHjXQgerdr5otK-U4yqwQn144T6dqIfuDqc2q4rzH_xn9fDF8QrhLQ</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Armstrong, Hilary F</creator><creator>Dussault, Nicole E</creator><creator>Thirapatarapong, Wilawan</creator><creator>Lemieux, Renee S</creator><creator>Thomashow, Byron M</creator><creator>Bartels, Matthew N</creator><general>Daedalus Enterprises, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>Ventilatory efficiency before and after lung volume reduction surgery</title><author>Armstrong, Hilary F ; Dussault, Nicole E ; Thirapatarapong, Wilawan ; Lemieux, Renee S ; Thomashow, Byron M ; Bartels, Matthew N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-c83e4a26aaf93a29453654536cf30af840755e5320cc03e6fdd2e34dedff5e543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Aged</topic><topic>Carbon Dioxide</topic><topic>Care and treatment</topic><topic>Exercise Test</topic><topic>Exercise Tolerance - physiology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Lung diseases, Obstructive</topic><topic>Lungs</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Oxygen Consumption</topic><topic>Patient outcomes</topic><topic>Physical Exertion - physiology</topic><topic>Pneumonectomy</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Disease, Chronic Obstructive - surgery</topic><topic>Pulmonary gas exchange</topic><topic>Pulmonary Gas Exchange - physiology</topic><topic>Pulmonary Ventilation - physiology</topic><topic>Residual Volume</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Tidal Volume</topic><topic>Vital Capacity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Armstrong, Hilary F</creatorcontrib><creatorcontrib>Dussault, Nicole E</creatorcontrib><creatorcontrib>Thirapatarapong, Wilawan</creatorcontrib><creatorcontrib>Lemieux, Renee S</creatorcontrib><creatorcontrib>Thomashow, Byron M</creatorcontrib><creatorcontrib>Bartels, Matthew N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory care</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Armstrong, Hilary F</au><au>Dussault, Nicole E</au><au>Thirapatarapong, Wilawan</au><au>Lemieux, Renee S</au><au>Thomashow, Byron M</au><au>Bartels, Matthew N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ventilatory efficiency before and after lung volume reduction surgery</atitle><jtitle>Respiratory care</jtitle><addtitle>Respir Care</addtitle><date>2015-01</date><risdate>2015</risdate><volume>60</volume><issue>1</issue><spage>63</spage><epage>71</epage><pages>63-71</pages><issn>0020-1324</issn><eissn>1943-3654</eissn><abstract>Lung volume reduction surgery (LVRS) has been shown to improve the clearance of carbon dioxide and minute ventilation (V̇E) in select patients with COPD. One variable often assessed in COPD is ventilatory efficiency (V̇E/V̇CO2 ).
We compared 55 LVRS subjects with 25 controls from the National Emphysema Treatment Trial. V̇E/V̇CO2 was calculated from cardiopulmonary exercise testing at baseline and 6-months. We sought to assess V̇E/V̇CO2 changes with LVRS compared with controls who only received standard medical care.
At 6 months, the LVRS group significantly increased peak V̇O2 , work load, V̇E, V̇CO2 , and tidal volume while lowering peak and lowest V̇E/V̇CO2 (improved ventilatory efficiency) and end-tidal carbon dioxide pressure. The control group did not display these changes. The changes were greatest in the LVRS subjects who improved their exercise capacity after surgery (> 10 W).
The changes were greatest in the LVRS subjects who showed the most functional improvement, indicating an association of improved ventilation with improved functional outcome.</abstract><cop>United States</cop><pub>Daedalus Enterprises, Inc</pub><pmid>25371397</pmid><doi>10.4187/respcare.03233</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aged Carbon Dioxide Care and treatment Exercise Test Exercise Tolerance - physiology Female Forced Expiratory Volume Health aspects Humans Lung diseases, Obstructive Lungs Male Middle Aged Oxygen Consumption Patient outcomes Physical Exertion - physiology Pneumonectomy Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - surgery Pulmonary gas exchange Pulmonary Gas Exchange - physiology Pulmonary Ventilation - physiology Residual Volume Retrospective Studies Surgery Tidal Volume Vital Capacity |
| title | Ventilatory efficiency before and after lung volume reduction surgery |
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