The role of elective neck dissection in early stage buccal cancer
Objectives/Hypothesis The benefits of elective neck dissection (END) in early‐stage tongue cancer have been widely discussed but are still controversial regarding early‐stage buccal cancer. In this study, we evaluate the role of END and the treatment outcome in early‐stage buccal cancer in an areca‐...
Gespeichert in:
| Veröffentlicht in: | The Laryngoscope 2015-01, Vol.125 (1), p.128-133 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 133 |
|---|---|
| container_issue | 1 |
| container_start_page | 128 |
| container_title | The Laryngoscope |
| container_volume | 125 |
| creator | Huang, Shiang-Fu Tung-Chieh Chang, Joseph Liao, Chun-Ta Kang, Chung-Jan Lin, Chien-Yu Fan, Kang-Hsing Wang, Hung-Ming Chen, I-How |
| description | Objectives/Hypothesis
The benefits of elective neck dissection (END) in early‐stage tongue cancer have been widely discussed but are still controversial regarding early‐stage buccal cancer. In this study, we evaluate the role of END and the treatment outcome in early‐stage buccal cancer in an areca‐quid endemic area.
Study Design
Retrospective case‐control study.
Methods
One hundred seventy‐three cT1‐2N0M0 buccal cancer patients all staged by computed tomography or magnetic resonance imaging were recruited. A total of 151 patients received radical surgery with END, whereas 22 received observation (OBS). Adjuvant radiotherapy with or without chemotherapy was given in selected high‐risk patients.
Results
The 5‐year overall survival (OS) rates for cT1 lesions and cT2 lesions were 86.14% and 75.45%, respectively (P = .105). In the END group, the occult metastasis rate was 1.8% for cT1 lesions and 10.6% for cT2 lesions (P = .053). The 5‐year neck control rate rates (P = .001) and disease‐free survival rates (P = .0101) were significantly better in the END group compared to the OBS group but were not significant in OS (P = .689). Eighteen (10.41%) patients developed a second primary tumor (SPT), and five (2.89%) patients developed a third primary tumor. Ninety‐four percent of SPTs were located within the oral cavity.
Conclusions
END was suggested in T1–T2N0 buccal cancer to improve the neck control rate. In patients for whom END is not performed at the time of tumor excision, regular follow‐up of neck status is necessary because the metastatic lesions are mostly salvageable and do not influence the OS.
Level of Evidence
4 Laryngoscope, 125:128–133, 2015 |
| doi_str_mv | 10.1002/lary.24840 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1641203320</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3535740301</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4650-cf1587fa6c935aebdbda370b3572750688efe6fd187f470a8cadc11de5e81dba3</originalsourceid><addsrcrecordid>eNp9kE1LAzEQhoMoWqsXf4AEvIiwmmw2m-yxFK1CUZSKH5eQzc7qtuluTbpq_72prR48eBiGYZ55GR6EDig5pYTEZ1a7xWmcyIRsoA7ljEZJlvFN1AlLFkkeP-6gXe_HhFDBONlGOzEnCUsl6aDe6BWwayzgpsRgwcyrd8A1mAkuKu-Xc1PjqsagnV1gP9cvgPPWGG2x0bUBt4e2Sm097K97F91fnI_6l9HwZnDV7w0jk6ScRKakXIpSpyZjXENe5IVmguSMi1hwkkoJJaRlQQOUCKKl0YWhtAAOkha5Zl10vMqdueatBT9X08obsFbX0LRe0TShMWEsVBcd_UHHTevq8F2gWJalwREL1MmKMq7x3kGpZq6aBpeKErUUq5Zi1bfYAB-uI9t8CsUv-mMyAHQFfFQWFv9EqWHv7uknNFrdVH4On7832k1UKpjg6uF6oG5Fn9_J7Flx9gUTqZFR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1639965313</pqid></control><display><type>article</type><title>The role of elective neck dissection in early stage buccal cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Huang, Shiang-Fu ; Tung-Chieh Chang, Joseph ; Liao, Chun-Ta ; Kang, Chung-Jan ; Lin, Chien-Yu ; Fan, Kang-Hsing ; Wang, Hung-Ming ; Chen, I-How</creator><creatorcontrib>Huang, Shiang-Fu ; Tung-Chieh Chang, Joseph ; Liao, Chun-Ta ; Kang, Chung-Jan ; Lin, Chien-Yu ; Fan, Kang-Hsing ; Wang, Hung-Ming ; Chen, I-How</creatorcontrib><description>Objectives/Hypothesis
The benefits of elective neck dissection (END) in early‐stage tongue cancer have been widely discussed but are still controversial regarding early‐stage buccal cancer. In this study, we evaluate the role of END and the treatment outcome in early‐stage buccal cancer in an areca‐quid endemic area.
Study Design
Retrospective case‐control study.
Methods
One hundred seventy‐three cT1‐2N0M0 buccal cancer patients all staged by computed tomography or magnetic resonance imaging were recruited. A total of 151 patients received radical surgery with END, whereas 22 received observation (OBS). Adjuvant radiotherapy with or without chemotherapy was given in selected high‐risk patients.
Results
The 5‐year overall survival (OS) rates for cT1 lesions and cT2 lesions were 86.14% and 75.45%, respectively (P = .105). In the END group, the occult metastasis rate was 1.8% for cT1 lesions and 10.6% for cT2 lesions (P = .053). The 5‐year neck control rate rates (P = .001) and disease‐free survival rates (P = .0101) were significantly better in the END group compared to the OBS group but were not significant in OS (P = .689). Eighteen (10.41%) patients developed a second primary tumor (SPT), and five (2.89%) patients developed a third primary tumor. Ninety‐four percent of SPTs were located within the oral cavity.
Conclusions
END was suggested in T1–T2N0 buccal cancer to improve the neck control rate. In patients for whom END is not performed at the time of tumor excision, regular follow‐up of neck status is necessary because the metastatic lesions are mostly salvageable and do not influence the OS.
Level of Evidence
4 Laryngoscope, 125:128–133, 2015</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.24840</identifier><identifier>PMID: 25043680</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; buccal cancer ; Cancer ; Case-Control Studies ; Cause of Death ; Disease-Free Survival ; Drug therapy ; Early stage ; Elective Surgical Procedures - methods ; Female ; Humans ; Lymphatic Metastasis - pathology ; Male ; Medical research ; Middle Aged ; Mouth Neoplasms - mortality ; Mouth Neoplasms - pathology ; Mouth Neoplasms - surgery ; neck dissection ; Neck Dissection - methods ; Neoplasm Staging ; Neoplasms, Second Primary - mortality ; Neoplasms, Second Primary - pathology ; Neoplasms, Second Primary - surgery ; Observation ; Retrospective Studies ; supraomohyoid neck dissection ; Taiwan</subject><ispartof>The Laryngoscope, 2015-01, Vol.125 (1), p.128-133</ispartof><rights>2014 The American Laryngological, Rhinological and Otological Society, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4650-cf1587fa6c935aebdbda370b3572750688efe6fd187f470a8cadc11de5e81dba3</citedby><cites>FETCH-LOGICAL-c4650-cf1587fa6c935aebdbda370b3572750688efe6fd187f470a8cadc11de5e81dba3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.24840$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.24840$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25043680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huang, Shiang-Fu</creatorcontrib><creatorcontrib>Tung-Chieh Chang, Joseph</creatorcontrib><creatorcontrib>Liao, Chun-Ta</creatorcontrib><creatorcontrib>Kang, Chung-Jan</creatorcontrib><creatorcontrib>Lin, Chien-Yu</creatorcontrib><creatorcontrib>Fan, Kang-Hsing</creatorcontrib><creatorcontrib>Wang, Hung-Ming</creatorcontrib><creatorcontrib>Chen, I-How</creatorcontrib><title>The role of elective neck dissection in early stage buccal cancer</title><title>The Laryngoscope</title><addtitle>The Laryngoscope</addtitle><description>Objectives/Hypothesis
The benefits of elective neck dissection (END) in early‐stage tongue cancer have been widely discussed but are still controversial regarding early‐stage buccal cancer. In this study, we evaluate the role of END and the treatment outcome in early‐stage buccal cancer in an areca‐quid endemic area.
Study Design
Retrospective case‐control study.
Methods
One hundred seventy‐three cT1‐2N0M0 buccal cancer patients all staged by computed tomography or magnetic resonance imaging were recruited. A total of 151 patients received radical surgery with END, whereas 22 received observation (OBS). Adjuvant radiotherapy with or without chemotherapy was given in selected high‐risk patients.
Results
The 5‐year overall survival (OS) rates for cT1 lesions and cT2 lesions were 86.14% and 75.45%, respectively (P = .105). In the END group, the occult metastasis rate was 1.8% for cT1 lesions and 10.6% for cT2 lesions (P = .053). The 5‐year neck control rate rates (P = .001) and disease‐free survival rates (P = .0101) were significantly better in the END group compared to the OBS group but were not significant in OS (P = .689). Eighteen (10.41%) patients developed a second primary tumor (SPT), and five (2.89%) patients developed a third primary tumor. Ninety‐four percent of SPTs were located within the oral cavity.
Conclusions
END was suggested in T1–T2N0 buccal cancer to improve the neck control rate. In patients for whom END is not performed at the time of tumor excision, regular follow‐up of neck status is necessary because the metastatic lesions are mostly salvageable and do not influence the OS.
Level of Evidence
4 Laryngoscope, 125:128–133, 2015</description><subject>Adult</subject><subject>Aged</subject><subject>buccal cancer</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Cause of Death</subject><subject>Disease-Free Survival</subject><subject>Drug therapy</subject><subject>Early stage</subject><subject>Elective Surgical Procedures - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - mortality</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - surgery</subject><subject>neck dissection</subject><subject>Neck Dissection - methods</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Second Primary - mortality</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Neoplasms, Second Primary - surgery</subject><subject>Observation</subject><subject>Retrospective Studies</subject><subject>supraomohyoid neck dissection</subject><subject>Taiwan</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LAzEQhoMoWqsXf4AEvIiwmmw2m-yxFK1CUZSKH5eQzc7qtuluTbpq_72prR48eBiGYZ55GR6EDig5pYTEZ1a7xWmcyIRsoA7ljEZJlvFN1AlLFkkeP-6gXe_HhFDBONlGOzEnCUsl6aDe6BWwayzgpsRgwcyrd8A1mAkuKu-Xc1PjqsagnV1gP9cvgPPWGG2x0bUBt4e2Sm097K97F91fnI_6l9HwZnDV7w0jk6ScRKakXIpSpyZjXENe5IVmguSMi1hwkkoJJaRlQQOUCKKl0YWhtAAOkha5Zl10vMqdueatBT9X08obsFbX0LRe0TShMWEsVBcd_UHHTevq8F2gWJalwREL1MmKMq7x3kGpZq6aBpeKErUUq5Zi1bfYAB-uI9t8CsUv-mMyAHQFfFQWFv9EqWHv7uknNFrdVH4On7832k1UKpjg6uF6oG5Fn9_J7Flx9gUTqZFR</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Huang, Shiang-Fu</creator><creator>Tung-Chieh Chang, Joseph</creator><creator>Liao, Chun-Ta</creator><creator>Kang, Chung-Jan</creator><creator>Lin, Chien-Yu</creator><creator>Fan, Kang-Hsing</creator><creator>Wang, Hung-Ming</creator><creator>Chen, I-How</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>The role of elective neck dissection in early stage buccal cancer</title><author>Huang, Shiang-Fu ; Tung-Chieh Chang, Joseph ; Liao, Chun-Ta ; Kang, Chung-Jan ; Lin, Chien-Yu ; Fan, Kang-Hsing ; Wang, Hung-Ming ; Chen, I-How</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4650-cf1587fa6c935aebdbda370b3572750688efe6fd187f470a8cadc11de5e81dba3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>buccal cancer</topic><topic>Cancer</topic><topic>Case-Control Studies</topic><topic>Cause of Death</topic><topic>Disease-Free Survival</topic><topic>Drug therapy</topic><topic>Early stage</topic><topic>Elective Surgical Procedures - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - mortality</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - surgery</topic><topic>neck dissection</topic><topic>Neck Dissection - methods</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Second Primary - mortality</topic><topic>Neoplasms, Second Primary - pathology</topic><topic>Neoplasms, Second Primary - surgery</topic><topic>Observation</topic><topic>Retrospective Studies</topic><topic>supraomohyoid neck dissection</topic><topic>Taiwan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Huang, Shiang-Fu</creatorcontrib><creatorcontrib>Tung-Chieh Chang, Joseph</creatorcontrib><creatorcontrib>Liao, Chun-Ta</creatorcontrib><creatorcontrib>Kang, Chung-Jan</creatorcontrib><creatorcontrib>Lin, Chien-Yu</creatorcontrib><creatorcontrib>Fan, Kang-Hsing</creatorcontrib><creatorcontrib>Wang, Hung-Ming</creatorcontrib><creatorcontrib>Chen, I-How</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huang, Shiang-Fu</au><au>Tung-Chieh Chang, Joseph</au><au>Liao, Chun-Ta</au><au>Kang, Chung-Jan</au><au>Lin, Chien-Yu</au><au>Fan, Kang-Hsing</au><au>Wang, Hung-Ming</au><au>Chen, I-How</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of elective neck dissection in early stage buccal cancer</atitle><jtitle>The Laryngoscope</jtitle><addtitle>The Laryngoscope</addtitle><date>2015-01</date><risdate>2015</risdate><volume>125</volume><issue>1</issue><spage>128</spage><epage>133</epage><pages>128-133</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objectives/Hypothesis
The benefits of elective neck dissection (END) in early‐stage tongue cancer have been widely discussed but are still controversial regarding early‐stage buccal cancer. In this study, we evaluate the role of END and the treatment outcome in early‐stage buccal cancer in an areca‐quid endemic area.
Study Design
Retrospective case‐control study.
Methods
One hundred seventy‐three cT1‐2N0M0 buccal cancer patients all staged by computed tomography or magnetic resonance imaging were recruited. A total of 151 patients received radical surgery with END, whereas 22 received observation (OBS). Adjuvant radiotherapy with or without chemotherapy was given in selected high‐risk patients.
Results
The 5‐year overall survival (OS) rates for cT1 lesions and cT2 lesions were 86.14% and 75.45%, respectively (P = .105). In the END group, the occult metastasis rate was 1.8% for cT1 lesions and 10.6% for cT2 lesions (P = .053). The 5‐year neck control rate rates (P = .001) and disease‐free survival rates (P = .0101) were significantly better in the END group compared to the OBS group but were not significant in OS (P = .689). Eighteen (10.41%) patients developed a second primary tumor (SPT), and five (2.89%) patients developed a third primary tumor. Ninety‐four percent of SPTs were located within the oral cavity.
Conclusions
END was suggested in T1–T2N0 buccal cancer to improve the neck control rate. In patients for whom END is not performed at the time of tumor excision, regular follow‐up of neck status is necessary because the metastatic lesions are mostly salvageable and do not influence the OS.
Level of Evidence
4 Laryngoscope, 125:128–133, 2015</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25043680</pmid><doi>10.1002/lary.24840</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 2015-01, Vol.125 (1), p.128-133 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1641203320 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged buccal cancer Cancer Case-Control Studies Cause of Death Disease-Free Survival Drug therapy Early stage Elective Surgical Procedures - methods Female Humans Lymphatic Metastasis - pathology Male Medical research Middle Aged Mouth Neoplasms - mortality Mouth Neoplasms - pathology Mouth Neoplasms - surgery neck dissection Neck Dissection - methods Neoplasm Staging Neoplasms, Second Primary - mortality Neoplasms, Second Primary - pathology Neoplasms, Second Primary - surgery Observation Retrospective Studies supraomohyoid neck dissection Taiwan |
| title | The role of elective neck dissection in early stage buccal cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T10%3A16%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20role%20of%20elective%20neck%20dissection%20in%20early%20stage%20buccal%20cancer&rft.jtitle=The%20Laryngoscope&rft.au=Huang,%20Shiang-Fu&rft.date=2015-01&rft.volume=125&rft.issue=1&rft.spage=128&rft.epage=133&rft.pages=128-133&rft.issn=0023-852X&rft.eissn=1531-4995&rft_id=info:doi/10.1002/lary.24840&rft_dat=%3Cproquest_cross%3E3535740301%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1639965313&rft_id=info:pmid/25043680&rfr_iscdi=true |