Cyclooxygenase-2 Regulates NLRP3 Inflammasome-Derived IL-1β Production

The NLR family, pyrin domain‐containing 3 (NLRP3) inflammasome is a reactive oxygen species‐sensitive multiprotein complex that regulates IL‐1β maturation via caspase‐1. It also plays an important role in the pathogenesis of inflammation‐related disease. Cyclooxygenase‐2 (COX‐2) is induced by inflam...

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Veröffentlicht in:	Journal of cellular physiology 2015-04, Vol.230 (4), p.863-874
Hauptverfasser:	Hua, Kuo-Feng, Chou, Ju-Ching, Ka, Shuk-Man, Tasi, Yu-Ling, Chen, Ann, Wu, Shih-Hsiung, Chiu, Hsiao-Wen, Wong, Wei-Ting, Wang, Yih-Fuh, Tsai, Change-Ling, Ho, Chen-Lung, Lin, Cheng-Hsiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carrier Proteins - metabolism Caspase 1 - metabolism Cyclooxygenase 2 - metabolism Gene Expression Regulation - physiology Inflammasomes - metabolism Inflammation - metabolism Interleukin-1beta - biosynthesis Lipopolysaccharides - toxicity Macrophages - metabolism Mice Mitochondria - metabolism NF-kappa B - metabolism NLR Family, Pyrin Domain-Containing 3 Protein Reactive Oxygen Species - metabolism Signal Transduction - physiology
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