Protective effects of taurine against closed head injury in rats

Taurine, an abundant amino acid in the nervous system, is reported to reduce ischemic brain injury in a dose-dependent manner. This study was designed to investigate whether taurine protected the brain against closed head injury (CHI) in rats. Taurine was administered intravenously 30 min after CHI....

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Veröffentlicht in:	Journal of neurotrauma 2015-01, Vol.32 (1), p.66-74
Hauptverfasser:	Sun, Ming, Zhao, Yumei, Gu, Yi, Zhang, Yazhuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain Edema - drug therapy Brain Edema - metabolism Cell Death - drug effects Dose-Response Relationship, Drug Edema Glutathione - metabolism Head injuries Head Injuries, Closed - drug therapy Head Injuries, Closed - metabolism Hippocampus - drug effects Hippocampus - metabolism Inflammation Laboratory animals Male Malondialdehyde - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oxidative Stress - drug effects Permeability Permeability - drug effects Rats Rats, Sprague-Dawley Superoxide Dismutase - metabolism Surgery Taurine - pharmacology Taurine - therapeutic use Trauma Traumatic brain injury
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