Protective effects of taurine against closed head injury in rats
Taurine, an abundant amino acid in the nervous system, is reported to reduce ischemic brain injury in a dose-dependent manner. This study was designed to investigate whether taurine protected the brain against closed head injury (CHI) in rats. Taurine was administered intravenously 30 min after CHI....
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| Veröffentlicht in: | Journal of neurotrauma 2015-01, Vol.32 (1), p.66-74 |
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| creator | Sun, Ming Zhao, Yumei Gu, Yi Zhang, Yazhuo |
| description | Taurine, an abundant amino acid in the nervous system, is reported to reduce ischemic brain injury in a dose-dependent manner. This study was designed to investigate whether taurine protected the brain against closed head injury (CHI) in rats. Taurine was administered intravenously 30 min after CHI. It was found that taurine lessened body-weight loss and improved neurological functions at 7 days after CHI. Moreover, it lowered brain edema and blood-brain barrier permeability, enhanced activity of superoxide dismutase and the level of glutathione, and reduced levels of malondialdehyde and lactic acid in traumatic tissue 24 h after CHI. In addition, it attenuated neuronal cell death in hippocampal CA1 and CA3 subfields 7 days after CHI. All of these effects were dose dependent. These data demonstrated the dose-dependent protection of taurine against experimental CHI and suggest that taurine treatment might be beneficial in reducing trauma-induced oxidative damage to the brain, thus showing the potential for clinical implications. |
| doi_str_mv | 10.1089/neu.2012.2432 |
| format | Article |
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This study was designed to investigate whether taurine protected the brain against closed head injury (CHI) in rats. Taurine was administered intravenously 30 min after CHI. It was found that taurine lessened body-weight loss and improved neurological functions at 7 days after CHI. Moreover, it lowered brain edema and blood-brain barrier permeability, enhanced activity of superoxide dismutase and the level of glutathione, and reduced levels of malondialdehyde and lactic acid in traumatic tissue 24 h after CHI. In addition, it attenuated neuronal cell death in hippocampal CA1 and CA3 subfields 7 days after CHI. All of these effects were dose dependent. 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This study was designed to investigate whether taurine protected the brain against closed head injury (CHI) in rats. Taurine was administered intravenously 30 min after CHI. It was found that taurine lessened body-weight loss and improved neurological functions at 7 days after CHI. Moreover, it lowered brain edema and blood-brain barrier permeability, enhanced activity of superoxide dismutase and the level of glutathione, and reduced levels of malondialdehyde and lactic acid in traumatic tissue 24 h after CHI. In addition, it attenuated neuronal cell death in hippocampal CA1 and CA3 subfields 7 days after CHI. All of these effects were dose dependent. These data demonstrated the dose-dependent protection of taurine against experimental CHI and suggest that taurine treatment might be beneficial in reducing trauma-induced oxidative damage to the brain, thus showing the potential for clinical implications.</description><subject>Alzheimer's disease</subject><subject>Animals</subject><subject>Blood-Brain Barrier - drug effects</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Brain Edema - drug therapy</subject><subject>Brain Edema - metabolism</subject><subject>Cell Death - drug effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Edema</subject><subject>Glutathione - metabolism</subject><subject>Head injuries</subject><subject>Head Injuries, Closed - drug therapy</subject><subject>Head Injuries, Closed - metabolism</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Inflammation</subject><subject>Laboratory animals</subject><subject>Male</subject><subject>Malondialdehyde - metabolism</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective Agents - therapeutic use</subject><subject>Oxidative Stress - drug effects</subject><subject>Permeability</subject><subject>Permeability - drug effects</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Surgery</subject><subject>Taurine - pharmacology</subject><subject>Taurine - therapeutic use</subject><subject>Trauma</subject><subject>Traumatic brain injury</subject><issn>0897-7151</issn><issn>1557-9042</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkE1LAzEQhoMotlaPXmXBi5etmXxs0ptS_IKCHvQc0mSiW7a7muwK_femtHrw9A4zDy_DQ8g50ClQPbtucZgyCmzKBGcHZAxSqnJGBTsk43xXpQIJI3KS0opS4BVTx2TEOGcKAMbk5iV2Pbq-_sYCQ8hTKrpQ9HaIdYuFfbd1m_rCNV1CX3yg9UXdroa4yVFE26dTchRsk_BsnxPydn_3On8sF88PT_PbRem4Vn3p0EsIQagwsxacW2qGXGNQeafBK6tm3LuKc6kr66n06IRyVouAikux5BNytev9jN3XgKk36zo5bBrbYjckA5UARjllOqOX_9BVN8Q2f5cpKUAwUCpT5Y5ysUspYjCfsV7buDFAzVatyWrNVq3Zqs38xb51WK7R_9G_LvkPeQh0HA</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Sun, Ming</creator><creator>Zhao, Yumei</creator><creator>Gu, Yi</creator><creator>Zhang, Yazhuo</creator><general>Mary Ann Liebert, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Protective effects of taurine against closed head injury in rats</title><author>Sun, Ming ; Zhao, Yumei ; Gu, Yi ; Zhang, Yazhuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-ced51ff47f9aa1ccb82e38ef7ff481d7a793dc633586ad05dec47ca84fe7354b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Alzheimer's disease</topic><topic>Animals</topic><topic>Blood-Brain Barrier - drug effects</topic><topic>Blood-Brain Barrier - metabolism</topic><topic>Brain Edema - drug therapy</topic><topic>Brain Edema - metabolism</topic><topic>Cell Death - drug effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Edema</topic><topic>Glutathione - metabolism</topic><topic>Head injuries</topic><topic>Head Injuries, Closed - drug therapy</topic><topic>Head Injuries, Closed - metabolism</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>Inflammation</topic><topic>Laboratory animals</topic><topic>Male</topic><topic>Malondialdehyde - metabolism</topic><topic>Neuroprotective Agents - pharmacology</topic><topic>Neuroprotective Agents - therapeutic use</topic><topic>Oxidative Stress - drug effects</topic><topic>Permeability</topic><topic>Permeability - drug effects</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Surgery</topic><topic>Taurine - pharmacology</topic><topic>Taurine - therapeutic use</topic><topic>Trauma</topic><topic>Traumatic brain injury</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Ming</creatorcontrib><creatorcontrib>Zhao, Yumei</creatorcontrib><creatorcontrib>Gu, Yi</creatorcontrib><creatorcontrib>Zhang, Yazhuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurotrauma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Ming</au><au>Zhao, Yumei</au><au>Gu, Yi</au><au>Zhang, Yazhuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effects of taurine against closed head injury in rats</atitle><jtitle>Journal of neurotrauma</jtitle><addtitle>J Neurotrauma</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>32</volume><issue>1</issue><spage>66</spage><epage>74</epage><pages>66-74</pages><issn>0897-7151</issn><eissn>1557-9042</eissn><abstract>Taurine, an abundant amino acid in the nervous system, is reported to reduce ischemic brain injury in a dose-dependent manner. 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| subjects | Alzheimer's disease Animals Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain Edema - drug therapy Brain Edema - metabolism Cell Death - drug effects Dose-Response Relationship, Drug Edema Glutathione - metabolism Head injuries Head Injuries, Closed - drug therapy Head Injuries, Closed - metabolism Hippocampus - drug effects Hippocampus - metabolism Inflammation Laboratory animals Male Malondialdehyde - metabolism Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Oxidative Stress - drug effects Permeability Permeability - drug effects Rats Rats, Sprague-Dawley Superoxide Dismutase - metabolism Surgery Taurine - pharmacology Taurine - therapeutic use Trauma Traumatic brain injury |
| title | Protective effects of taurine against closed head injury in rats |
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