Thiazide‐Sensitive Na+‐Cl− Cotransporter (NCC) Gene Inactivation Results in Increased Duodenal Ca2+ Absorption, Enhanced Osteoblast Differentiation and Elevated Bone Mineral Density

Inactivation of the thiazide‐sensitive sodium chloride cotransporter (NCC) due to genetic mutations in Gitelman's syndrome (GS) or pharmacological inhibition with thiazide diuretics causes hypocalciuria and increased bone mineral density (BMD) with unclear extrarenal calcium (Ca2+) regulation....

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Veröffentlicht in:	Journal of bone and mineral research 2015-01, Vol.30 (1), p.116-127
Hauptverfasser:	Hsu, Yu‐Juei, Yang, Sung‐Sen, Cheng, Chih‐Jen, Liu, Shu‐Ting, Huang, Shih‐Ming, Chau, Tom, Chu, Pauling, Salter, Donald M, Lee, Herng‐Sheng, Lin, Shih‐Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Density - physiology CALCIUM Calcium - metabolism Cell Differentiation - physiology Duodenum - cytology Duodenum - metabolism Extracellular Signal-Regulated MAP Kinases - genetics Extracellular Signal-Regulated MAP Kinases - metabolism Focal Adhesion Kinase 1 - genetics Focal Adhesion Kinase 1 - metabolism Gene Knock-In Techniques GITELMAN'S SYNDROME Intestinal Absorption - physiology INTESTINE Ion Transport - physiology Mice Mice, Transgenic OSTEOBLAST DIFFERENTIATION Osteoblasts - cytology Osteoblasts - metabolism Solute Carrier Family 12, Member 3 - genetics Solute Carrier Family 12, Member 3 - metabolism THIAZIDES
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