Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols

Genome-wide association study of virologic response with efavirenz-containing or abacavir-containing regimens in AIDS clinical trials group protocols

BACKGROUNDEfavirenz and abacavir are components of recommended first-line regimens for HIV-1 infection. We used genome-wide genotyping and clinical data to explore genetic associations with virologic failure among patients randomized to efavirenz-containing or abacavir-containing regimens in AIDS Cl...

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Veröffentlicht in:Pharmacogenetics and genomics 2015-02, Vol.25 (2), p.51-59
Hauptverfasser: Lehmann, David S, Ribaudo, Heather J, Daar, Eric S, Gulick, Roy M, Haubrich, Richard H, Robbins, Gregory K, de Bakker, Paul I.W, Haas, David W, McLaren, Paul J
Format: Artikel
Sprache:eng
Schlagworte:
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - epidemiology
Acquired Immunodeficiency Syndrome - genetics
Anti-HIV Agents - therapeutic use
Benzoxazines - administration & dosage
Dideoxynucleosides - administration & dosage
Drug Therapy, Combination
Genome-Wide Association Study - statistics & numerical data
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - genetics
HIV-1 - drug effects
Humans
Polymorphism, Single Nucleotide
Randomized Controlled Trials as Topic
Treatment Outcome
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Zusammenfassung:BACKGROUNDEfavirenz and abacavir are components of recommended first-line regimens for HIV-1 infection. We used genome-wide genotyping and clinical data to explore genetic associations with virologic failure among patients randomized to efavirenz-containing or abacavir-containing regimens in AIDS Clinical Trials Group (ACTG) protocols. PARTICIPANTS AND METHODSVirologic response and genome-wide genotype data were available from treatment-naive patients randomized to efavirenz-containing (n=1596) or abacavir-containing (n=786) regimens in ACTG protocols 384, A5142, A5095, and A5202. RESULTSMeta-analysis of association results across race/ethnic groups showed no genome-wide significant associations (P
ISSN:1744-6872
1744-6880
DOI:10.1097/FPC.0000000000000106