Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus
Intracellular and whole-cell recording from CA1 pyramidal cells and dentate granule cells was used to study the release of endogenous GABA by nipecotic acid. Local application of nipecotic acid produced responses that could be entirely blocked by a combination of the GABA A receptor antagonist picro...
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| Veröffentlicht in: | Neuroscience letters 1992-11, Vol.147 (1), p.16-20 |
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| creator | Solís, JoséM. Nicoll, Roger A. |
| description | Intracellular and whole-cell recording from CA1 pyramidal cells and dentate granule cells was used to study the release of endogenous GABA by nipecotic acid. Local application of nipecotic acid produced responses that could be entirely blocked by a combination of the GABA
A receptor antagonist picrotoxin and the GABA
B receptor antagonist CGP 35348. These responses were due to the heteroexchange release of endogenous GABA because they were blocked by low Na
+ which blocks the GABA transporter and by SKF 89976 which is a competitive antagonist of the GABA transporter. Local application of nipecotic acid could, depending on the location, evoke pure GABA
A or pure GABA
B responses supporting proposals that GABA
A and GABA
B receptors can be segregated at separate inhibitory synapses. |
| doi_str_mv | 10.1016/0304-3940(92)90764-X |
| format | Article |
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A receptor antagonist picrotoxin and the GABA
B receptor antagonist CGP 35348. These responses were due to the heteroexchange release of endogenous GABA because they were blocked by low Na
+ which blocks the GABA transporter and by SKF 89976 which is a competitive antagonist of the GABA transporter. Local application of nipecotic acid could, depending on the location, evoke pure GABA
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A receptor antagonist picrotoxin and the GABA
B receptor antagonist CGP 35348. These responses were due to the heteroexchange release of endogenous GABA because they were blocked by low Na
+ which blocks the GABA transporter and by SKF 89976 which is a competitive antagonist of the GABA transporter. Local application of nipecotic acid could, depending on the location, evoke pure GABA
A or pure GABA
B responses supporting proposals that GABA
A and GABA
B receptors can be segregated at separate inhibitory synapses.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - metabolism</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Electrodes</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GABA A receptor</subject><subject>GABA B receptor</subject><subject>GABA uptake</subject><subject>GABA-A Receptor Antagonists</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>gamma-Aminobutyric Acid - physiology</subject><subject>Guinea Pigs</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>In Vitro Techniques</subject><subject>Nipecotic Acids - pharmacology</subject><subject>Organophosphorus Compounds - pharmacology</subject><subject>Picrotoxin - pharmacology</subject><subject>Proline - analogs & derivatives</subject><subject>Pyramidal Tracts - drug effects</subject><subject>Pyramidal Tracts - metabolism</subject><subject>Rats</subject><subject>Synapses - drug effects</subject><subject>Synapses - physiology</subject><subject>Tetrodotoxin - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFLHDEYhkOp2NX2H1jIoYg9TJsvyUw2F2ErrRYEPSh4C5nkG02ZTabJrLD_vrPOYm-evsP7vC8fDyEnwL4Bg-Y7E0xWQkt2pvlXzVQjq4d3ZAFLxSulFX9PFq_IB3JUyh_GWA21PCSHIEQDNSzI3W0qY9lGO4zBUevGkCJNHcXo0yPGtCn0cvVjRTP2aAt62m5pDAO6NPPB0xDp-IT0KQxDcnY9bMpHctDZvuCn_T0m979-3l1cVdc3l78vVteVk6DGqtONtksmZGs5oOzaRqlaYMuwVtI73nCBVvlaO2hFi0pLDS1H5WWNjgEXx-R03h1y-rvBMpp1KA773kacPjfQSACxFBMoZ9DlVErGzgw5rG3eGmBmJ9PsTJmdKaO5eZFpHqba5_3-pl2j_1-a7U35l31ui7N9l210obxiUuglqGbCzmcMJxfPAbMpLmB06ENGNxqfwtt__AOlxZAo</recordid><startdate>19921123</startdate><enddate>19921123</enddate><creator>Solís, JoséM.</creator><creator>Nicoll, Roger A.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope></search><sort><creationdate>19921123</creationdate><title>Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus</title><author>Solís, JoséM. ; Nicoll, Roger A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f969a8034ba21e4fb67753eb0e574dc2623ea7d59c1b3be79491b2e7d45ec0123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - metabolism</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Electrodes</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GABA A receptor</topic><topic>GABA B receptor</topic><topic>GABA uptake</topic><topic>GABA-A Receptor Antagonists</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>gamma-Aminobutyric Acid - physiology</topic><topic>Guinea Pigs</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - metabolism</topic><topic>In Vitro Techniques</topic><topic>Nipecotic Acids - pharmacology</topic><topic>Organophosphorus Compounds - pharmacology</topic><topic>Picrotoxin - pharmacology</topic><topic>Proline - analogs & derivatives</topic><topic>Pyramidal Tracts - drug effects</topic><topic>Pyramidal Tracts - metabolism</topic><topic>Rats</topic><topic>Synapses - drug effects</topic><topic>Synapses - physiology</topic><topic>Tetrodotoxin - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solís, JoséM.</creatorcontrib><creatorcontrib>Nicoll, Roger A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solís, JoséM.</au><au>Nicoll, Roger A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1992-11-23</date><risdate>1992</risdate><volume>147</volume><issue>1</issue><spage>16</spage><epage>20</epage><pages>16-20</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Intracellular and whole-cell recording from CA1 pyramidal cells and dentate granule cells was used to study the release of endogenous GABA by nipecotic acid. Local application of nipecotic acid produced responses that could be entirely blocked by a combination of the GABA
A receptor antagonist picrotoxin and the GABA
B receptor antagonist CGP 35348. These responses were due to the heteroexchange release of endogenous GABA because they were blocked by low Na
+ which blocks the GABA transporter and by SKF 89976 which is a competitive antagonist of the GABA transporter. Local application of nipecotic acid could, depending on the location, evoke pure GABA
A or pure GABA
B responses supporting proposals that GABA
A and GABA
B receptors can be segregated at separate inhibitory synapses.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1336151</pmid><doi>10.1016/0304-3940(92)90764-X</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1992-11, Vol.147 (1), p.16-20 |
| issn | 0304-3940 1872-7972 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_16411383 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Biological and medical sciences Carrier Proteins - metabolism Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Electrodes Fundamental and applied biological sciences. Psychology GABA A receptor GABA B receptor GABA uptake GABA-A Receptor Antagonists gamma-Aminobutyric Acid - metabolism gamma-Aminobutyric Acid - physiology Guinea Pigs Hippocampus Hippocampus - drug effects Hippocampus - metabolism In Vitro Techniques Nipecotic Acids - pharmacology Organophosphorus Compounds - pharmacology Picrotoxin - pharmacology Proline - analogs & derivatives Pyramidal Tracts - drug effects Pyramidal Tracts - metabolism Rats Synapses - drug effects Synapses - physiology Tetrodotoxin - pharmacology Vertebrates: nervous system and sense organs |
| title | Postsynaptic action of endogenous GABA released by nipecotic acid in the hippocampus |
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