Nucleosides and Nucleotides. 108. Synthesis and Optical Properties of Syn-Fixed Carbon-Bridged Pyrimidine Cyclonucleosides

6, 1'-Propanouridine (10), a carbon-bridged cyclouridine fixed in the syn-conformation, was synthesized from D-fructose. Two additional carbon-units were introduced at the 1'-position of 1'-hydroxymethyl-O2, 2'-anhydrouridine 13 and inversion of the 2' hydroxyl group was ach...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1992/07/25, Vol.40(7), pp.1761-1769
Hauptverfasser:	YOSHIMURA, Yuichi, OTTER, Brian A., UEDA, Tohru, MATSUDA, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	6, 1'-propanouridine carbon-bridge cyclonucleoside CD spectrum conformation glycosyl torsion angle nucleoside radical cyclization syn-anti conformation
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