Cloning of a yeast 8-oxoguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily

Background Reactive oxygen species, ionizing radiation, and other free radical generators initiate the conversion of guanine (G) residues in DNA to 8-oxoguanine (OG), which is highly mutagenic as it preferentially mispairs with adenine (A) during replication. Bacteria counter this threat with a mult...

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Veröffentlicht in:	Current biology 1996-08, Vol.6 (8), p.968-980
Hauptverfasser:	Nash, Huw M., Bruner, Steven D., Schärer, Orlando D., Kawate, Tomohiko, Addona, Theresa A., Spooner, Eric, Lane, William S., Verdine, Gregory L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Base Sequence Cloning, Molecular DNA Repair - genetics DNA-Formamidopyrimidine Glycosylase Escherichia coli Proteins Molecular Sequence Data Multigene Family N-Glycosyl Hydrolases - genetics N-Glycosyl Hydrolases - isolation & purification N-Glycosyl Hydrolases - metabolism Oligodeoxyribonucleotides Saccharomyces cerevisiae - genetics Substrate Specificity
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