Investigation of the Impact of Substrate Selection on In Vitro Organic Anion Transporting Polypeptide 1B1 Inhibition Profiles for the Prediction of Drug-Drug Interactions

The risk assessment of organic anion transporting polypeptide (OATP) 1B1–mediated drug-drug interactions (DDIs) is an indispensable part of drug development. We previously reported that in vitro inhibitory potencies of several inhibitors on OATP1B1 depend on the substrates when prototypical substrat...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug metabolism and disposition 2015-02, Vol.43 (2), p.235-247
Hauptverfasser:	Izumi, Saki, Nozaki, Yoshitane, Maeda, Kazuya, Komori, Takafumi, Takenaka, Osamu, Kusuhara, Hiroyuki, Sugiyama, Yuichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Antihypertensive Agents - metabolism Binding, Competitive Biological Transport - drug effects Cyclohexanes - metabolism Cyclosporine - pharmacology Drug Evaluation, Preclinical Drug Interactions Estradiol - analogs & derivatives Estradiol - metabolism Gemfibrozil - pharmacology HEK293 Cells Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism Hypoglycemic Agents - metabolism Kinetics Membrane Transport Modulators - pharmacology Models, Biological Organic Anion Transporters - antagonists & inhibitors Organic Anion Transporters - genetics Organic Anion Transporters - metabolism Phenylalanine - analogs & derivatives Phenylalanine - metabolism Recombinant Proteins - metabolism Rifampin - pharmacology Solute Carrier Organic Anion Transporter Family Member 1b1 Sulfonamides - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!