Anti-fibrillation potency of caffeic acid against an antidepressant induced fibrillogenesis of human α-synuclein: Implications for Parkinson's disease

Alpha synuclein is a 14 kDa intrinsically disordered, presynaptic protein whose fibrillation is a critical step in the pathogenesis of Parkinson's disease (PD). A structural investigation of the effect of escitalopram (a selective serotonin reuptake inhibitor) on α-synuclein was performed using...

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Veröffentlicht in:	Biochimie 2015-01, Vol.108, p.178-185
Hauptverfasser:	Fazili, Naveed Ahmad, Naeem, Aabgeena
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry Anilino Naphthalenesulfonates - chemistry Antidepressive Agents - pharmacology Atomic force microscopy Caffeic acid Caffeic Acids - chemistry Caffeic Acids - pharmacology Caffeic Acids - therapeutic use Drug Design Escitalopram Humans Hydrophobic and Hydrophilic Interactions Models, Molecular Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease Presynaptic protein Protein Aggregates - drug effects Protein Structure, Secondary - drug effects Transmission electron microscopy
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