Folding intermediates of wild-type and mutants of barnase. II. correlation of changes in equilibrium amide exchange kinetics with the population of the folding intermediate

There is an unanswered question from previous studies of 1H/ 2H-exchange of amide protons of barnase. Under certain conditions, there is a relatively abrupt change from EX2 towards EX1 kinetics as the temperature is slightly increased. The change in kinetics for different mutants is not directly rel...

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Veröffentlicht in:Journal of molecular biology 1998-02, Vol.276 (3), p.647-656
Hauptverfasser: Dalby, Paul A., Clarke, Jane, Johnson, Christopher M., Fersht, Alan R.
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Sprache:eng
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