Insulin-resistance HCV infection-related affects vascular stiffness in normotensives
Abstract Background and Aims . Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence art...
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| Veröffentlicht in: | Atherosclerosis 2015-01, Vol.238 (1), p.108-112 |
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| creator | Perticone, Maria Maio, Raffaele Tassone, Eliezer Joseph Tripepi, Giovanni Di Cello, Serena Miceli, Sofia Caroleo, Benedetto Sciacqua, Angela Licata, Anna Sesti, Giorgio Perticone, Francesco |
| description | Abstract Background and Aims . Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence arterial stiffness. Methods . We enrolled 260 outpatients matched for age, body mass index, gender, ethnicity: 52 with never-treated uncomplicated chronic hepatitis C virus infection (HCV+ ), 104 never-treated hypertensives (HT) and 104 healthy subjects (NT). Pulse wave velocity was evaluated by a validated system employing high-fidelity applanation tonometry. We also measured: fasting plasma glucose and insulin, total, LDL- and HDL-cholesterol, triglyceride, creatinine, e-GFR-EPI, HOMA, quantitative HCV-RNA. Results . HCV+ patients with respect to NT had an increased pulse wave velocity (7.9 ± 2.1 vs 6.4 ± 2.1 m/s; P |
| doi_str_mv | 10.1016/j.atherosclerosis.2014.11.025 |
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Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence arterial stiffness. Methods . We enrolled 260 outpatients matched for age, body mass index, gender, ethnicity: 52 with never-treated uncomplicated chronic hepatitis C virus infection (HCV+ ), 104 never-treated hypertensives (HT) and 104 healthy subjects (NT). Pulse wave velocity was evaluated by a validated system employing high-fidelity applanation tonometry. We also measured: fasting plasma glucose and insulin, total, LDL- and HDL-cholesterol, triglyceride, creatinine, e-GFR-EPI, HOMA, quantitative HCV-RNA. Results . HCV+ patients with respect to NT had an increased pulse wave velocity (7.9 ± 2.1 vs 6.4 ± 2.1 m/s; P < 0.0001), similar to that observed in HT group (8.8 ± 3.2 m/s). HCV+ patients, in comparison with NT, had higher triglyceride, creatinine, fasting insulin and HOMA (3.2 ± 1.3 vs 2.5 ± 1.0; P < 0.0001). At linear regression analysis, the correlation between pulse wave velocity and HOMA was similar in HT ( r = 0.380, P < 0.0001) and HCV+ ( r = 0.369, P = 0.004) groups. At multiple regression analysis, HOMA resulted the major determinant of pulse wave velocity in all groups, explaining respectively 11.8%, 14.4% and 13.6% of its variation in NT, HT and HCV+ . At correlational analysis hepatitis C virus-RNA and HOMA demonstrated a strong and linear relationship between them, explaining the 72.4% of their variation ( P = 0.022). Conclusions . We demonstrated a significant and direct correlation between HOMA and pulse wave velocity in HCV+ patients, similar to that observed in hypertensives.</description><identifier>ISSN: 0021-9150</identifier><identifier>EISSN: 1879-1484</identifier><identifier>DOI: 10.1016/j.atherosclerosis.2014.11.025</identifier><identifier>PMID: 25461736</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adult ; Arterial stiffness ; Blood Pressure ; Body Mass Index ; Cardiovascular ; Case-Control Studies ; Chronic hepatitis C virus infection ; Female ; Hepatitis C, Chronic - blood ; Hepatitis C, Chronic - complications ; Humans ; Hyperinsulinism - blood ; Hyperinsulinism - complications ; Hypertension ; Insulin - blood ; Insulin Resistance ; Linear Models ; Male ; Middle Aged ; Pulse Wave Analysis ; Risk Factors ; Vascular Stiffness</subject><ispartof>Atherosclerosis, 2015-01, Vol.238 (1), p.108-112</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2014 Elsevier Ireland Ltd</rights><rights>Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-ef0954f18fb8bcd19470d597ff4ecb42a379553fb77e4df2c167f5cf76d88f4a3</citedby><cites>FETCH-LOGICAL-c510t-ef0954f18fb8bcd19470d597ff4ecb42a379553fb77e4df2c167f5cf76d88f4a3</cites><orcidid>0000-0003-2402-0981</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.atherosclerosis.2014.11.025$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25461736$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Perticone, Maria</creatorcontrib><creatorcontrib>Maio, Raffaele</creatorcontrib><creatorcontrib>Tassone, Eliezer Joseph</creatorcontrib><creatorcontrib>Tripepi, Giovanni</creatorcontrib><creatorcontrib>Di Cello, Serena</creatorcontrib><creatorcontrib>Miceli, Sofia</creatorcontrib><creatorcontrib>Caroleo, Benedetto</creatorcontrib><creatorcontrib>Sciacqua, Angela</creatorcontrib><creatorcontrib>Licata, Anna</creatorcontrib><creatorcontrib>Sesti, Giorgio</creatorcontrib><creatorcontrib>Perticone, Francesco</creatorcontrib><title>Insulin-resistance HCV infection-related affects vascular stiffness in normotensives</title><title>Atherosclerosis</title><addtitle>Atherosclerosis</addtitle><description>Abstract Background and Aims . Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence arterial stiffness. Methods . We enrolled 260 outpatients matched for age, body mass index, gender, ethnicity: 52 with never-treated uncomplicated chronic hepatitis C virus infection (HCV+ ), 104 never-treated hypertensives (HT) and 104 healthy subjects (NT). Pulse wave velocity was evaluated by a validated system employing high-fidelity applanation tonometry. We also measured: fasting plasma glucose and insulin, total, LDL- and HDL-cholesterol, triglyceride, creatinine, e-GFR-EPI, HOMA, quantitative HCV-RNA. Results . HCV+ patients with respect to NT had an increased pulse wave velocity (7.9 ± 2.1 vs 6.4 ± 2.1 m/s; P < 0.0001), similar to that observed in HT group (8.8 ± 3.2 m/s). HCV+ patients, in comparison with NT, had higher triglyceride, creatinine, fasting insulin and HOMA (3.2 ± 1.3 vs 2.5 ± 1.0; P < 0.0001). At linear regression analysis, the correlation between pulse wave velocity and HOMA was similar in HT ( r = 0.380, P < 0.0001) and HCV+ ( r = 0.369, P = 0.004) groups. At multiple regression analysis, HOMA resulted the major determinant of pulse wave velocity in all groups, explaining respectively 11.8%, 14.4% and 13.6% of its variation in NT, HT and HCV+ . At correlational analysis hepatitis C virus-RNA and HOMA demonstrated a strong and linear relationship between them, explaining the 72.4% of their variation ( P = 0.022). Conclusions . We demonstrated a significant and direct correlation between HOMA and pulse wave velocity in HCV+ patients, similar to that observed in hypertensives.</description><subject>Adult</subject><subject>Arterial stiffness</subject><subject>Blood Pressure</subject><subject>Body Mass Index</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Chronic hepatitis C virus infection</subject><subject>Female</subject><subject>Hepatitis C, Chronic - blood</subject><subject>Hepatitis C, Chronic - complications</subject><subject>Humans</subject><subject>Hyperinsulinism - blood</subject><subject>Hyperinsulinism - complications</subject><subject>Hypertension</subject><subject>Insulin - blood</subject><subject>Insulin Resistance</subject><subject>Linear Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pulse Wave Analysis</subject><subject>Risk Factors</subject><subject>Vascular Stiffness</subject><issn>0021-9150</issn><issn>1879-1484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFr3DAQhUVpSLZp_kLxpdCLHY0tWfKhhbK0SSCQQ9NehSyPqLZeOdXYC_n3kdm0h5xy0YDmzRvme4x9BF4Bh_ZyV9n5N6aJ3Li-gaqag6gAKl7LN2wDWnUlCC3esg3nNZQdSH7G3hHtOOdCgT5lZ7UULaim3bD7m0jLGGKZMHvNNjosrre_ihA9ujlMa2O0Mw6F9esPFQdLbhltKmgO3kckyuIiTmk_zRgpHJDesxNvR8KL53rOfn7_dr-9Lm_vrm62X29LJ4HPJXreSeFB-173boBOKD7ITnkv0PWito3qpGx8rxSKwdcOWuWl86odtPbCNufs09H3IU1_F6TZ7AM5HEcbcVrIQCu4llBryNLPR6nL0CihNw8p7G16NMDNCtbszAuwZgVrAEwGm-c_PK9a-j0O_6f_kcyCq6MA88GHgMmQC5hxDiFlbmaYwqtXfXnh5HJAwdnxDz4i7aYlxUzVgKHacPNjTXkNGUT25tA0TyvpqnQ</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Perticone, Maria</creator><creator>Maio, Raffaele</creator><creator>Tassone, Eliezer Joseph</creator><creator>Tripepi, Giovanni</creator><creator>Di Cello, Serena</creator><creator>Miceli, Sofia</creator><creator>Caroleo, Benedetto</creator><creator>Sciacqua, Angela</creator><creator>Licata, Anna</creator><creator>Sesti, Giorgio</creator><creator>Perticone, Francesco</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2402-0981</orcidid></search><sort><creationdate>20150101</creationdate><title>Insulin-resistance HCV infection-related affects vascular stiffness in normotensives</title><author>Perticone, Maria ; Maio, Raffaele ; Tassone, Eliezer Joseph ; Tripepi, Giovanni ; Di Cello, Serena ; Miceli, Sofia ; Caroleo, Benedetto ; Sciacqua, Angela ; Licata, Anna ; Sesti, Giorgio ; Perticone, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-ef0954f18fb8bcd19470d597ff4ecb42a379553fb77e4df2c167f5cf76d88f4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Arterial stiffness</topic><topic>Blood Pressure</topic><topic>Body Mass Index</topic><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>Chronic hepatitis C virus infection</topic><topic>Female</topic><topic>Hepatitis C, Chronic - blood</topic><topic>Hepatitis C, Chronic - complications</topic><topic>Humans</topic><topic>Hyperinsulinism - blood</topic><topic>Hyperinsulinism - complications</topic><topic>Hypertension</topic><topic>Insulin - blood</topic><topic>Insulin Resistance</topic><topic>Linear Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pulse Wave Analysis</topic><topic>Risk Factors</topic><topic>Vascular Stiffness</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perticone, Maria</creatorcontrib><creatorcontrib>Maio, Raffaele</creatorcontrib><creatorcontrib>Tassone, Eliezer Joseph</creatorcontrib><creatorcontrib>Tripepi, Giovanni</creatorcontrib><creatorcontrib>Di Cello, Serena</creatorcontrib><creatorcontrib>Miceli, Sofia</creatorcontrib><creatorcontrib>Caroleo, Benedetto</creatorcontrib><creatorcontrib>Sciacqua, Angela</creatorcontrib><creatorcontrib>Licata, Anna</creatorcontrib><creatorcontrib>Sesti, Giorgio</creatorcontrib><creatorcontrib>Perticone, Francesco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Atherosclerosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Perticone, Maria</au><au>Maio, Raffaele</au><au>Tassone, Eliezer Joseph</au><au>Tripepi, Giovanni</au><au>Di Cello, Serena</au><au>Miceli, Sofia</au><au>Caroleo, Benedetto</au><au>Sciacqua, Angela</au><au>Licata, Anna</au><au>Sesti, Giorgio</au><au>Perticone, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insulin-resistance HCV infection-related affects vascular stiffness in normotensives</atitle><jtitle>Atherosclerosis</jtitle><addtitle>Atherosclerosis</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>238</volume><issue>1</issue><spage>108</spage><epage>112</epage><pages>108-112</pages><issn>0021-9150</issn><eissn>1879-1484</eissn><abstract>Abstract Background and Aims . Arterial stiffness evaluated as pulse wave velocity, is an early marker of vascular damage and an independent predictor for cardiovascular events. We investigated if the insulin resistance/hyperinsulinemia chronic hepatitis C virus infection-related could influence arterial stiffness. Methods . We enrolled 260 outpatients matched for age, body mass index, gender, ethnicity: 52 with never-treated uncomplicated chronic hepatitis C virus infection (HCV+ ), 104 never-treated hypertensives (HT) and 104 healthy subjects (NT). Pulse wave velocity was evaluated by a validated system employing high-fidelity applanation tonometry. We also measured: fasting plasma glucose and insulin, total, LDL- and HDL-cholesterol, triglyceride, creatinine, e-GFR-EPI, HOMA, quantitative HCV-RNA. Results . HCV+ patients with respect to NT had an increased pulse wave velocity (7.9 ± 2.1 vs 6.4 ± 2.1 m/s; P < 0.0001), similar to that observed in HT group (8.8 ± 3.2 m/s). HCV+ patients, in comparison with NT, had higher triglyceride, creatinine, fasting insulin and HOMA (3.2 ± 1.3 vs 2.5 ± 1.0; P < 0.0001). At linear regression analysis, the correlation between pulse wave velocity and HOMA was similar in HT ( r = 0.380, P < 0.0001) and HCV+ ( r = 0.369, P = 0.004) groups. At multiple regression analysis, HOMA resulted the major determinant of pulse wave velocity in all groups, explaining respectively 11.8%, 14.4% and 13.6% of its variation in NT, HT and HCV+ . At correlational analysis hepatitis C virus-RNA and HOMA demonstrated a strong and linear relationship between them, explaining the 72.4% of their variation ( P = 0.022). Conclusions . We demonstrated a significant and direct correlation between HOMA and pulse wave velocity in HCV+ patients, similar to that observed in hypertensives.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>25461736</pmid><doi>10.1016/j.atherosclerosis.2014.11.025</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-2402-0981</orcidid></addata></record> |
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| subjects | Adult Arterial stiffness Blood Pressure Body Mass Index Cardiovascular Case-Control Studies Chronic hepatitis C virus infection Female Hepatitis C, Chronic - blood Hepatitis C, Chronic - complications Humans Hyperinsulinism - blood Hyperinsulinism - complications Hypertension Insulin - blood Insulin Resistance Linear Models Male Middle Aged Pulse Wave Analysis Risk Factors Vascular Stiffness |
| title | Insulin-resistance HCV infection-related affects vascular stiffness in normotensives |
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