Next-generation sequencing for hereditary breast and gynecologic cancer risk assessment

To summarize advances in next-generation sequencing and their application to breast and gynecologic cancer risk assessment. Next-generation sequencing panels of 6-112 cancer-associated genes are increasingly used in patient care. Studies report a 4-16% prevalence of mutations other than BRCA1/2 amon...

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Veröffentlicht in:	Current opinion in obstetrics & gynecology 2015-02, Vol.27 (1), p.23-33
Hauptverfasser:	Kurian, Allison W, Kingham, Kerry E, Ford, James M
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - genetics Breast Neoplasms - prevention & control Breast Neoplasms - psychology Female Genes, BRCA1 Genes, BRCA2 Genetic Counseling Genetic Predisposition to Disease Genetic Testing Genital Neoplasms, Female - genetics Genital Neoplasms, Female - prevention & control Genital Neoplasms, Female - psychology High-Throughput Nucleotide Sequencing Humans Mutation Patient Selection Practice Guidelines as Topic Risk Assessment Risk Factors Sequence Analysis, DNA - methods
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