Does lymph node involvement affect the patterns of recurrence in stage IB cervical cancer?
To investigate the variations in the recurrence patterns of stage IB cervical cancer according to lymph node involvement. We reviewed the medical records of 170 patients who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007. Among the patients in the study...
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| Veröffentlicht in: | Turkish journal of medical sciences 2014, Vol.44 (5), p.844-852 |
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| container_title | Turkish journal of medical sciences |
| container_volume | 44 |
| creator | Üreyen, Işın Aksoy, Ülkü Dündar, Betül Tapisiz, Ömer Lütfi Karalök, Mustafa Alper Turan, Ahmet Taner Boran, Nurettin Tulunay, Hakkı Gökhan |
| description | To investigate the variations in the recurrence patterns of stage IB cervical cancer according to lymph node involvement.
We reviewed the medical records of 170 patients who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007.
Among the patients in the study group, 115 did not have lymph node metastases, whereas 55 did. A total of 27 patients developed recurrences. Twelve were in the lymph node-negative group, and 15 were in the lymph node-positive group. The recurrence rate was higher in lymph node-positive group (27.3% versus 10.4%, P = 0.011). The recurrence pattern was not affected by lymph node involvement. However, distant recurrence was more common in the lymph node-positive group (53.3% versus 25%, P = 0.137). Additionally, distant failure was observed only in the patients in the lymph node-negative group who received adjuvant radiotherapy. In this group, 3 patients who did not receive adjuvant radiotherapy developed recurrences only in the pelvic region.
The presence of lymph node involvement in stage IB cervical cancer does not affect the site of recurrence. However, distant recurrence was more frequent in the lymph node-positive group. |
| doi_str_mv | 10.3906/sag-1212-3 |
| format | Article |
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We reviewed the medical records of 170 patients who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007.
Among the patients in the study group, 115 did not have lymph node metastases, whereas 55 did. A total of 27 patients developed recurrences. Twelve were in the lymph node-negative group, and 15 were in the lymph node-positive group. The recurrence rate was higher in lymph node-positive group (27.3% versus 10.4%, P = 0.011). The recurrence pattern was not affected by lymph node involvement. However, distant recurrence was more common in the lymph node-positive group (53.3% versus 25%, P = 0.137). Additionally, distant failure was observed only in the patients in the lymph node-negative group who received adjuvant radiotherapy. In this group, 3 patients who did not receive adjuvant radiotherapy developed recurrences only in the pelvic region.
The presence of lymph node involvement in stage IB cervical cancer does not affect the site of recurrence. However, distant recurrence was more frequent in the lymph node-positive group.</description><identifier>ISSN: 1300-0144</identifier><identifier>EISSN: 1303-6165</identifier><identifier>DOI: 10.3906/sag-1212-3</identifier><identifier>PMID: 25539556</identifier><language>eng</language><publisher>Turkey</publisher><subject>Adenocarcinoma - pathology ; Carcinoma, Adenosquamous - pathology ; Female ; Humans ; Hysterectomy ; Lymph Node Excision ; Lymphatic Metastasis ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - prevention & control ; Prognosis ; Radiotherapy, Adjuvant ; Retrospective Studies ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - radiotherapy ; Uterine Cervical Neoplasms - surgery</subject><ispartof>Turkish journal of medical sciences, 2014, Vol.44 (5), p.844-852</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c323t-c09eaac1b37994edbdb8ebd0a56458f3c758975ba7bf027a23f0f1781c48df2a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25539556$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Üreyen, Işın</creatorcontrib><creatorcontrib>Aksoy, Ülkü</creatorcontrib><creatorcontrib>Dündar, Betül</creatorcontrib><creatorcontrib>Tapisiz, Ömer Lütfi</creatorcontrib><creatorcontrib>Karalök, Mustafa Alper</creatorcontrib><creatorcontrib>Turan, Ahmet Taner</creatorcontrib><creatorcontrib>Boran, Nurettin</creatorcontrib><creatorcontrib>Tulunay, Hakkı Gökhan</creatorcontrib><title>Does lymph node involvement affect the patterns of recurrence in stage IB cervical cancer?</title><title>Turkish journal of medical sciences</title><addtitle>Turk J Med Sci</addtitle><description>To investigate the variations in the recurrence patterns of stage IB cervical cancer according to lymph node involvement.
We reviewed the medical records of 170 patients who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007.
Among the patients in the study group, 115 did not have lymph node metastases, whereas 55 did. A total of 27 patients developed recurrences. Twelve were in the lymph node-negative group, and 15 were in the lymph node-positive group. The recurrence rate was higher in lymph node-positive group (27.3% versus 10.4%, P = 0.011). The recurrence pattern was not affected by lymph node involvement. However, distant recurrence was more common in the lymph node-positive group (53.3% versus 25%, P = 0.137). Additionally, distant failure was observed only in the patients in the lymph node-negative group who received adjuvant radiotherapy. In this group, 3 patients who did not receive adjuvant radiotherapy developed recurrences only in the pelvic region.
The presence of lymph node involvement in stage IB cervical cancer does not affect the site of recurrence. However, distant recurrence was more frequent in the lymph node-positive group.</description><subject>Adenocarcinoma - pathology</subject><subject>Carcinoma, Adenosquamous - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Lymph Node Excision</subject><subject>Lymphatic Metastasis</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - prevention & control</subject><subject>Prognosis</subject><subject>Radiotherapy, Adjuvant</subject><subject>Retrospective Studies</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - radiotherapy</subject><subject>Uterine Cervical Neoplasms - surgery</subject><issn>1300-0144</issn><issn>1303-6165</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kEtLAzEUhYMotlY3_gDJUoTRPCbzWInWV6HgRjduwp3MTTsyL5NMof_eqVVX98D9OHA-Qs45u5Y5S248rCIuuIjkAZlyyWSU8EQd_mQWMR7HE3Li_SdjQsYqPyYToZTMlUqm5OOhQ0_rbdOvaduVSKt209UbbLANFKxFE2hYI-0hBHStp52lDs3gHLZmR1MfYIV0cU8Nuk1loKYGxpe7PSVHFmqPZ793Rt6fHt_mL9Hy9Xkxv1tGRgoZIsNyBDC8kGmex1gWZZFhUTJQSawyK02qsjxVBaSFZSIFIS2zPM24ibPSCpAzcrnv7V33NaAPuqm8wbqGFrvBa57ELMkyNW6ekas9alznvUOre1c14LaaM71zqUeXeudSyxG--O0digbLf_RPnvwG3Z9v_Q</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Üreyen, Işın</creator><creator>Aksoy, Ülkü</creator><creator>Dündar, Betül</creator><creator>Tapisiz, Ömer Lütfi</creator><creator>Karalök, Mustafa Alper</creator><creator>Turan, Ahmet Taner</creator><creator>Boran, Nurettin</creator><creator>Tulunay, Hakkı Gökhan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Does lymph node involvement affect the patterns of recurrence in stage IB cervical cancer?</title><author>Üreyen, Işın ; Aksoy, Ülkü ; Dündar, Betül ; Tapisiz, Ömer Lütfi ; Karalök, Mustafa Alper ; Turan, Ahmet Taner ; Boran, Nurettin ; Tulunay, Hakkı Gökhan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c323t-c09eaac1b37994edbdb8ebd0a56458f3c758975ba7bf027a23f0f1781c48df2a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adenocarcinoma - pathology</topic><topic>Carcinoma, Adenosquamous - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Lymph Node Excision</topic><topic>Lymphatic Metastasis</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - prevention & control</topic><topic>Prognosis</topic><topic>Radiotherapy, Adjuvant</topic><topic>Retrospective Studies</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - radiotherapy</topic><topic>Uterine Cervical Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Üreyen, Işın</creatorcontrib><creatorcontrib>Aksoy, Ülkü</creatorcontrib><creatorcontrib>Dündar, Betül</creatorcontrib><creatorcontrib>Tapisiz, Ömer Lütfi</creatorcontrib><creatorcontrib>Karalök, Mustafa Alper</creatorcontrib><creatorcontrib>Turan, Ahmet Taner</creatorcontrib><creatorcontrib>Boran, Nurettin</creatorcontrib><creatorcontrib>Tulunay, Hakkı Gökhan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Turkish journal of medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Üreyen, Işın</au><au>Aksoy, Ülkü</au><au>Dündar, Betül</au><au>Tapisiz, Ömer Lütfi</au><au>Karalök, Mustafa Alper</au><au>Turan, Ahmet Taner</au><au>Boran, Nurettin</au><au>Tulunay, Hakkı Gökhan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does lymph node involvement affect the patterns of recurrence in stage IB cervical cancer?</atitle><jtitle>Turkish journal of medical sciences</jtitle><addtitle>Turk J Med Sci</addtitle><date>2014</date><risdate>2014</risdate><volume>44</volume><issue>5</issue><spage>844</spage><epage>852</epage><pages>844-852</pages><issn>1300-0144</issn><eissn>1303-6165</eissn><abstract>To investigate the variations in the recurrence patterns of stage IB cervical cancer according to lymph node involvement.
We reviewed the medical records of 170 patients who had undergone type III radical hysterectomy and systematic lymphadenectomy from 1993 to 2007.
Among the patients in the study group, 115 did not have lymph node metastases, whereas 55 did. A total of 27 patients developed recurrences. Twelve were in the lymph node-negative group, and 15 were in the lymph node-positive group. The recurrence rate was higher in lymph node-positive group (27.3% versus 10.4%, P = 0.011). The recurrence pattern was not affected by lymph node involvement. However, distant recurrence was more common in the lymph node-positive group (53.3% versus 25%, P = 0.137). Additionally, distant failure was observed only in the patients in the lymph node-negative group who received adjuvant radiotherapy. In this group, 3 patients who did not receive adjuvant radiotherapy developed recurrences only in the pelvic region.
The presence of lymph node involvement in stage IB cervical cancer does not affect the site of recurrence. However, distant recurrence was more frequent in the lymph node-positive group.</abstract><cop>Turkey</cop><pmid>25539556</pmid><doi>10.3906/sag-1212-3</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Turkish journal of medical sciences, 2014, Vol.44 (5), p.844-852 |
| issn | 1300-0144 1303-6165 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; TÜBİTAK Scientific Journals |
| subjects | Adenocarcinoma - pathology Carcinoma, Adenosquamous - pathology Female Humans Hysterectomy Lymph Node Excision Lymphatic Metastasis Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - prevention & control Prognosis Radiotherapy, Adjuvant Retrospective Studies Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - radiotherapy Uterine Cervical Neoplasms - surgery |
| title | Does lymph node involvement affect the patterns of recurrence in stage IB cervical cancer? |
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