Down-regulation of MSH2 expression by Hsp90 inhibition enhances cytotoxicity affected by tamoxifen in human lung cancer cells

[Display omitted] •Tamoxifen increased MSH2 mRNA and protein levels in an AKT-dependent manner.•Knocking down MSH2 expression enhanced the cell growth inhibition of tamoxifen.•Tamoxifen combined with an Hsp90 inhibitor resulted in synergistically cytotoxicity. The anti-estrogen tamoxifen has been us...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-01, Vol.456 (1), p.506-512
Hauptverfasser:	Ko, Jen-Chung, Chiu, Hsien-Chun, Syu, Jhan-Jhang, Chen, Chien-Yu, Jian, Yun-Ting, Huang, Yi-Jhen, Wo, Ting-Yu, Jian, Yi-Jun, Chang, Po-Yuan, Wang, Tai-Jing, Lin, Yun-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Cell Line, Tumor Cell Proliferation - drug effects Down-Regulation Drug Synergism Gene Expression Profiling Gene Expression Regulation, Neoplastic HSP90 Heat-Shock Proteins - metabolism Hsp90 inhibition Humans Lung Neoplasms - metabolism MSH2 MutS Homolog 2 Protein - metabolism Non-small cell lung cancer Proto-Oncogene Proteins c-akt - metabolism RNA, Messenger - metabolism RNA, Small Interfering - metabolism Tamoxifen Tamoxifen - therapeutic use Transfection
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