Anti-inflammatory and Protective Properties of Daphnetin in Endotoxin-Induced Lung Injury

Uncontrolled inflammatory responses cause tissue injury and severe immunopathology. Pharmacological interference of intracellular pro-inflammatory signaling may confer a therapeutic benefit under these conditions. Daphnetin, a natural coumarin derivative, has been used to treat inflammatory diseases...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2014-12, Vol.62 (51), p.12315-12325
Hauptverfasser:	Yu, Wen-wen, Lu, Zhe, Zhang, Hang, Kang, Yan-hua, Mao, Yun, Wang, Huan-huan, Ge, Wei-hong, Shi, Li-yun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals anti-inflammatory activity Anti-Inflammatory Agents - administration & dosage bronchitis coumarin Endotoxins - toxicity epithelial cells Humans immunopathology inflammation lipopolysaccharides Lung Injury - chemically induced Lung Injury - genetics Lung Injury - immunology Lung Injury - prevention & control macrophage activation macrophages Macrophages - drug effects Macrophages - immunology Mice Mice, Inbred C57BL NF-kappa B - genetics NF-kappa B - immunology pathogenesis Protective Agents - administration & dosage protective effect transcription factor NF-kappa B Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - immunology ubiquitination Umbelliferones - administration & dosage
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