Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system

Significance Multidrug recognition is an important phenomenon that is not well understood. TipA, a bacterial transcriptional regulator, constitutes a minimal multidrug resistance system against numerous thiopeptide antibiotics. We show that motions in the millisecond to microsecond time range form t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-12, Vol.111 (51), p.E5498-E5507
Hauptverfasser:	Habazettl, Judith, Allan, Martin, Jensen, Pernille Rose, Sass, Hans-Jürgen, Thompson, Charles J, Grzesiek, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Anti-Bacterial Agents - pharmacology Antibiotics Bacteria Bacteria - drug effects Bacterial Proteins - chemistry Bacterial Proteins - metabolism Binding sites Biological Sciences Biosynthesis Drug resistance Drug Resistance, Multiple, Bacterial drugs multiple drug resistance Nuclear Magnetic Resonance, Biomolecular Peptides PNAS Plus Protein folding ribosomes Thiostrepton - chemistry transcription factors
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