α₄β₂ Nicotinic receptor stimulation of the GABAergic system within the orbitofrontal cortex ameliorates the severe crossmodal object recognition impairment in ketamine-treated rats: implications for cognitive dysfunction in schizophrenia

Schizophrenia is associated with atypical multisensory integration. Rats treated sub-chronically with NMDA receptor antagonists to model schizophrenia are severely impaired on a tactile-to-visual crossmodal object recognition (CMOR) task, and this deficit is reversed by systemic nicotine. The curren...

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Veröffentlicht in:	Neuropharmacology 2015-03, Vol.90, p.42-52
Hauptverfasser:	Cloke, Jacob M, Winters, Boyer D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal gamma-Aminobutyric Acid - metabolism Glutamic Acid - metabolism Ketamine Male Neuropsychological Tests Prefrontal Cortex - drug effects Prefrontal Cortex - physiopathology Random Allocation Rats, Long-Evans Receptors, Nicotinic - metabolism Recognition (Psychology) - drug effects Recognition (Psychology) - physiology Schizophrenia - physiopathology Schizophrenic Psychology
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