A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: A meta-analysis
Background and Aim Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFL...
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| Veröffentlicht in: | Journal of gastroenterology and hepatology 2015-01, Vol.30 (1), p.21-27 |
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| creator | Zain, Shamsul Mohd Mohamed, Zahurin Mohamed, Rosmawati |
| description | Background and Aim
Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined. This meta‐analysis was performed to evaluate the effect strength caused by GCKR rs780094 on NAFLD.
Methods
We searched Medline, PubMed, Scopus, and Embase for relevant articles published up to April 2014. Data were extracted, and summary estimates of the association between GCKR rs780094 and NAFLD were examined. Heterogeneity and publication bias were also examined.
Results
This meta‐analysis incorporated a total of 2091 NAFLD cases and 3003 controls from five studies. Overall, the pooled result indicated that the GCKR rs780094 was significantly associated with increased risk of NAFLD (additive: odds ratio (OR) 1.25, 95% confidence interval (CI) 1.14–1.36, P |
| doi_str_mv | 10.1111/jgh.12714 |
| format | Article |
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Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined. This meta‐analysis was performed to evaluate the effect strength caused by GCKR rs780094 on NAFLD.
Methods
We searched Medline, PubMed, Scopus, and Embase for relevant articles published up to April 2014. Data were extracted, and summary estimates of the association between GCKR rs780094 and NAFLD were examined. Heterogeneity and publication bias were also examined.
Results
This meta‐analysis incorporated a total of 2091 NAFLD cases and 3003 controls from five studies. Overall, the pooled result indicated that the GCKR rs780094 was significantly associated with increased risk of NAFLD (additive: odds ratio (OR) 1.25, 95% confidence interval (CI) 1.14–1.36, P < 0.00001). Analysis also revealed significant associations with different alternative genetic models for the inheritance: dominant, recessive, and homozygote (OR 1.40, 95%CI 1.23–1.61, P < 0.00001; OR 0.79, 95% CI 0.68–0.91, P = 0.001, and; (OR 1.27, 95% CI 1.10–1.47, P = 0.001, respectively), but not the heterozygote model. Population subgroup analysis demonstrated similar effect size in both Asians and non‐Asians (OR 1.27, 95%CI 1.12–1.45, P = 0.0003 and OR 1.22, 95%CI 1.10–1.37, P = 0.0003, respectively).
Conclusions
Our meta‐analysis provides evidence of significant association between GCKR rs780094 and risk of NAFLD. Similar effect size was demonstrated in both Asian and non‐Asian populations.</description><identifier>ISSN: 0815-9319</identifier><identifier>EISSN: 1440-1746</identifier><identifier>DOI: 10.1111/jgh.12714</identifier><identifier>PMID: 25167786</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Adaptor Proteins, Signal Transducing - genetics ; Asian Continental Ancestry Group - genetics ; Databases, Bibliographic ; GCKR ; Genetic Predisposition to Disease - genetics ; genetic variation ; Humans ; meta-analysis ; NAFLD ; Non-alcoholic Fatty Liver Disease - genetics ; Risk ; rs780094</subject><ispartof>Journal of gastroenterology and hepatology, 2015-01, Vol.30 (1), p.21-27</ispartof><rights>2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd</rights><rights>2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4294-5160bb0b164a2aec947e05d09fffa39387423dabeace22966dd27c39d79948d33</citedby><cites>FETCH-LOGICAL-c4294-5160bb0b164a2aec947e05d09fffa39387423dabeace22966dd27c39d79948d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjgh.12714$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjgh.12714$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25167786$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zain, Shamsul Mohd</creatorcontrib><creatorcontrib>Mohamed, Zahurin</creatorcontrib><creatorcontrib>Mohamed, Rosmawati</creatorcontrib><title>A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: A meta-analysis</title><title>Journal of gastroenterology and hepatology</title><addtitle>J Gastroenterol Hepatol</addtitle><description>Background and Aim
Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined. This meta‐analysis was performed to evaluate the effect strength caused by GCKR rs780094 on NAFLD.
Methods
We searched Medline, PubMed, Scopus, and Embase for relevant articles published up to April 2014. Data were extracted, and summary estimates of the association between GCKR rs780094 and NAFLD were examined. Heterogeneity and publication bias were also examined.
Results
This meta‐analysis incorporated a total of 2091 NAFLD cases and 3003 controls from five studies. Overall, the pooled result indicated that the GCKR rs780094 was significantly associated with increased risk of NAFLD (additive: odds ratio (OR) 1.25, 95% confidence interval (CI) 1.14–1.36, P < 0.00001). Analysis also revealed significant associations with different alternative genetic models for the inheritance: dominant, recessive, and homozygote (OR 1.40, 95%CI 1.23–1.61, P < 0.00001; OR 0.79, 95% CI 0.68–0.91, P = 0.001, and; (OR 1.27, 95% CI 1.10–1.47, P = 0.001, respectively), but not the heterozygote model. Population subgroup analysis demonstrated similar effect size in both Asians and non‐Asians (OR 1.27, 95%CI 1.12–1.45, P = 0.0003 and OR 1.22, 95%CI 1.10–1.37, P = 0.0003, respectively).
Conclusions
Our meta‐analysis provides evidence of significant association between GCKR rs780094 and risk of NAFLD. Similar effect size was demonstrated in both Asian and non‐Asian populations.</description><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Asian Continental Ancestry Group - genetics</subject><subject>Databases, Bibliographic</subject><subject>GCKR</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>genetic variation</subject><subject>Humans</subject><subject>meta-analysis</subject><subject>NAFLD</subject><subject>Non-alcoholic Fatty Liver Disease - genetics</subject><subject>Risk</subject><subject>rs780094</subject><issn>0815-9319</issn><issn>1440-1746</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1v1DAQhi1ERbeFA38A-QiHtP5KHHNbreiWqgIJgSpxsRxnsuuuE7d20jb8eky37Y25jEZ63kejF6H3lJzQPKfXm-0JZZKKV2hBhSAFlaJ6jRakpmWhOFWH6Cila0KIILJ8gw5ZSSsp62qB_iyxDX0fBnxnojPDiN2Axy3gjZ9s2LnBJMARNpM3Y4gz3sCQ7yRrQpTAZmhxdGmHQ4eHMBhvwzZ4Z3FnxnHG3t1BxK1LkC2f8RL3MJrCZG5OLr1FB53xCd497WP06-zLz9V5cfl9_XW1vCysYEoU-VXSNKShlTDMgFVCAilborquM1zxWgrGW9OAscCYqqq2ZdJy1UqlRN1yfow-7r03MdxOkEbdu2TBezNAmJLOYiJqkldGP-1RG0NKETp9E11v4qwp0f-q1rlq_Vh1Zj88aaemh_aFfO42A6d74N55mP9v0hfr82dlsU-4NMLDS8LEna4kl6W--rbWv1dldcUuiP7B_wLcypdU</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Zain, Shamsul Mohd</creator><creator>Mohamed, Zahurin</creator><creator>Mohamed, Rosmawati</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: A meta-analysis</title><author>Zain, Shamsul Mohd ; Mohamed, Zahurin ; Mohamed, Rosmawati</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4294-5160bb0b164a2aec947e05d09fffa39387423dabeace22966dd27c39d79948d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adaptor Proteins, Signal Transducing - genetics</topic><topic>Asian Continental Ancestry Group - genetics</topic><topic>Databases, Bibliographic</topic><topic>GCKR</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>genetic variation</topic><topic>Humans</topic><topic>meta-analysis</topic><topic>NAFLD</topic><topic>Non-alcoholic Fatty Liver Disease - genetics</topic><topic>Risk</topic><topic>rs780094</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zain, Shamsul Mohd</creatorcontrib><creatorcontrib>Mohamed, Zahurin</creatorcontrib><creatorcontrib>Mohamed, Rosmawati</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology and hepatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zain, Shamsul Mohd</au><au>Mohamed, Zahurin</au><au>Mohamed, Rosmawati</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: A meta-analysis</atitle><jtitle>Journal of gastroenterology and hepatology</jtitle><addtitle>J Gastroenterol Hepatol</addtitle><date>2015-01</date><risdate>2015</risdate><volume>30</volume><issue>1</issue><spage>21</spage><epage>27</epage><pages>21-27</pages><issn>0815-9319</issn><eissn>1440-1746</eissn><abstract>Background and Aim
Although studies have suggested that rs780094, a common variant in the glucokinase regulatory (GCKR) gene to be associated with type 2 diabetes, obesity, and their related traits, the genetic basis of the association between GCKR rs780094 and nonalcoholic fatty liver disease (NAFLD) is still being examined. This meta‐analysis was performed to evaluate the effect strength caused by GCKR rs780094 on NAFLD.
Methods
We searched Medline, PubMed, Scopus, and Embase for relevant articles published up to April 2014. Data were extracted, and summary estimates of the association between GCKR rs780094 and NAFLD were examined. Heterogeneity and publication bias were also examined.
Results
This meta‐analysis incorporated a total of 2091 NAFLD cases and 3003 controls from five studies. Overall, the pooled result indicated that the GCKR rs780094 was significantly associated with increased risk of NAFLD (additive: odds ratio (OR) 1.25, 95% confidence interval (CI) 1.14–1.36, P < 0.00001). Analysis also revealed significant associations with different alternative genetic models for the inheritance: dominant, recessive, and homozygote (OR 1.40, 95%CI 1.23–1.61, P < 0.00001; OR 0.79, 95% CI 0.68–0.91, P = 0.001, and; (OR 1.27, 95% CI 1.10–1.47, P = 0.001, respectively), but not the heterozygote model. Population subgroup analysis demonstrated similar effect size in both Asians and non‐Asians (OR 1.27, 95%CI 1.12–1.45, P = 0.0003 and OR 1.22, 95%CI 1.10–1.37, P = 0.0003, respectively).
Conclusions
Our meta‐analysis provides evidence of significant association between GCKR rs780094 and risk of NAFLD. Similar effect size was demonstrated in both Asian and non‐Asian populations.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25167786</pmid><doi>10.1111/jgh.12714</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adaptor Proteins, Signal Transducing - genetics Asian Continental Ancestry Group - genetics Databases, Bibliographic GCKR Genetic Predisposition to Disease - genetics genetic variation Humans meta-analysis NAFLD Non-alcoholic Fatty Liver Disease - genetics Risk rs780094 |
| title | A common variant in the glucokinase regulatory gene rs780094 and risk of nonalcoholic fatty liver disease: A meta-analysis |
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