Increased activity of MMP‐2 in hypertensive obese children is associated with hypoadiponectinemia
Objective To compare the circulating levels of MMP‐2 and TIMP‐2 and the MMP‐2/TIMP‐2 ratio in control, obese, and obese hypertensive children and adolescents and to assess whether hypoadiponectinemia is associated with MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios. Methods Studies were carried out...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2015-01, Vol.23 (1), p.177-182 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Belo, Vanessa A. Lacchini, Riccardo Miranda, Josiane A. Lanna, Carla M.M. Souza‐Costa, Debora C. Tanus‐Santos, Jose E. |
| description | Objective
To compare the circulating levels of MMP‐2 and TIMP‐2 and the MMP‐2/TIMP‐2 ratio in control, obese, and obese hypertensive children and adolescents and to assess whether hypoadiponectinemia is associated with MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Methods
Studies were carried out with 53 control, 73 obese, and 29 obese hypertensive children and adolescents in this cross‐sectional study. Adiponectin and TIMP‐2 concentrations were measured by ELISA. MMP‐2 concentrations were measured by gelatin zymography. Multiple linear regression analysis was carried out to assess the effects of adiponectin on MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Results
The obese hypertensive group had the lowest adiponectin levels among groups (P |
| doi_str_mv | 10.1002/oby.20939 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1640328299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1640328299</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3539-f2387d6126ed76053ef2be7998e5b39597f33ef904805693ebaf74c3b6d2860d3</originalsourceid><addsrcrecordid>eNp10MtKAzEYhuEgiq3VhTcgATe6aJvDnLLU4qHQUhcKuhoymX9oynRSk2nL7LwEr9ErMbW1C8FVQnh4CR9C55T0KCGsb7Kmx4jg4gC1qeCkG3Pxeri_J7SFTpybERJEJKTHqMXCgMQ8ZG2khpWyIB3kWKpar3TdYFPg8fjp6-OTYV3habMAW0Pl9AqwycABVlNd5hYqrB2WzhmlZe0Da11PN9zIXC9MBb5XwVzLU3RUyNLB2e7soJf7u-fBY3c0eRgObkZdxUMuugXjSZxHlEWQx_6jHAqWQSxEAmHGRSjigvs3QYKEhJHgkMkiDhTPopwlEcl5B11tuwtr3pfg6nSunYKylBWYpUtpFBDOEiaEp5d_6MwsbeV_51UcChpQlnh1vVXKGucsFOnC6rm0TUpJulk-9cunP8t7e7ErLrM55Hv5O7UH_S1Y6xKa_0vp5PZtm_wGL_GN0Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1675914128</pqid></control><display><type>article</type><title>Increased activity of MMP‐2 in hypertensive obese children is associated with hypoadiponectinemia</title><source>MEDLINE</source><source>Wiley Free Content</source><source>Wiley Online Library All Journals</source><creator>Belo, Vanessa A. ; Lacchini, Riccardo ; Miranda, Josiane A. ; Lanna, Carla M.M. ; Souza‐Costa, Debora C. ; Tanus‐Santos, Jose E.</creator><creatorcontrib>Belo, Vanessa A. ; Lacchini, Riccardo ; Miranda, Josiane A. ; Lanna, Carla M.M. ; Souza‐Costa, Debora C. ; Tanus‐Santos, Jose E.</creatorcontrib><description>Objective
To compare the circulating levels of MMP‐2 and TIMP‐2 and the MMP‐2/TIMP‐2 ratio in control, obese, and obese hypertensive children and adolescents and to assess whether hypoadiponectinemia is associated with MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Methods
Studies were carried out with 53 control, 73 obese, and 29 obese hypertensive children and adolescents in this cross‐sectional study. Adiponectin and TIMP‐2 concentrations were measured by ELISA. MMP‐2 concentrations were measured by gelatin zymography. Multiple linear regression analysis was carried out to assess the effects of adiponectin on MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Results
The obese hypertensive group had the lowest adiponectin levels among groups (P < 0.05) while obese subjects had lower adiponectin levels than control subjects (P < 0.05). Obese hypertensive subjects also had higher circulating MMP‐2 concentrations than obese subjects (P < 0.05) and had the highest MMP‐2/TIMP‐2 ratios among groups (P < 0.05). Moreover, obese/hypertensive subjects had the lowest TIMP‐2 levels among groups (P < 0.05). A multiple linear regression analysis showed that MMP‐2 levels and MMP‐2/TIMP‐2 ratios are negatively associated with adiponectin levels (P = 0.034 and P = 0.011, respectively) while TIMP‐2 levels is positively associated with adiponectin levels (P = 0.013).
Conclusions
Increased activity of MMP‐2 (MMP‐2/TIMP‐2 ratio) and reduced TIMP‐2 levels may play an important role in clinical hypertension of childhood obesity. Additionally, hypoadiponectinemia may contribute to increased activity of MMP‐2 in obese/hypertensive children and adolescents.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20939</identifier><identifier>PMID: 25407352</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adiponectin - deficiency ; Adiponectin - metabolism ; Adolescent ; Atherosclerosis ; Bands ; Bioavailability ; Blood pressure ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Diabetes ; Endocrinology ; Enzyme-Linked Immunosorbent Assay ; Enzymes ; Female ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - metabolism ; Insulin ; Insulin resistance ; Male ; Matrix Metalloproteinase 2 - blood ; Matrix Metalloproteinase 2 - metabolism ; Metabolism, Inborn Errors - complications ; Metabolism, Inborn Errors - metabolism ; Obesity ; Pathogenesis ; Pediatric Obesity - complications ; Pediatric Obesity - metabolism ; Ratios ; Regression Analysis ; Teenagers ; Tissue Inhibitor of Metalloproteinase-2 - blood</subject><ispartof>Obesity (Silver Spring, Md.), 2015-01, Vol.23 (1), p.177-182</ispartof><rights>2014 The Obesity Society</rights><rights>2014 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Jan 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3539-f2387d6126ed76053ef2be7998e5b39597f33ef904805693ebaf74c3b6d2860d3</citedby><cites>FETCH-LOGICAL-c3539-f2387d6126ed76053ef2be7998e5b39597f33ef904805693ebaf74c3b6d2860d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20939$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20939$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25407352$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belo, Vanessa A.</creatorcontrib><creatorcontrib>Lacchini, Riccardo</creatorcontrib><creatorcontrib>Miranda, Josiane A.</creatorcontrib><creatorcontrib>Lanna, Carla M.M.</creatorcontrib><creatorcontrib>Souza‐Costa, Debora C.</creatorcontrib><creatorcontrib>Tanus‐Santos, Jose E.</creatorcontrib><title>Increased activity of MMP‐2 in hypertensive obese children is associated with hypoadiponectinemia</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
To compare the circulating levels of MMP‐2 and TIMP‐2 and the MMP‐2/TIMP‐2 ratio in control, obese, and obese hypertensive children and adolescents and to assess whether hypoadiponectinemia is associated with MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Methods
Studies were carried out with 53 control, 73 obese, and 29 obese hypertensive children and adolescents in this cross‐sectional study. Adiponectin and TIMP‐2 concentrations were measured by ELISA. MMP‐2 concentrations were measured by gelatin zymography. Multiple linear regression analysis was carried out to assess the effects of adiponectin on MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Results
The obese hypertensive group had the lowest adiponectin levels among groups (P < 0.05) while obese subjects had lower adiponectin levels than control subjects (P < 0.05). Obese hypertensive subjects also had higher circulating MMP‐2 concentrations than obese subjects (P < 0.05) and had the highest MMP‐2/TIMP‐2 ratios among groups (P < 0.05). Moreover, obese/hypertensive subjects had the lowest TIMP‐2 levels among groups (P < 0.05). A multiple linear regression analysis showed that MMP‐2 levels and MMP‐2/TIMP‐2 ratios are negatively associated with adiponectin levels (P = 0.034 and P = 0.011, respectively) while TIMP‐2 levels is positively associated with adiponectin levels (P = 0.013).
Conclusions
Increased activity of MMP‐2 (MMP‐2/TIMP‐2 ratio) and reduced TIMP‐2 levels may play an important role in clinical hypertension of childhood obesity. Additionally, hypoadiponectinemia may contribute to increased activity of MMP‐2 in obese/hypertensive children and adolescents.</description><subject>Adiponectin - deficiency</subject><subject>Adiponectin - metabolism</subject><subject>Adolescent</subject><subject>Atherosclerosis</subject><subject>Bands</subject><subject>Bioavailability</subject><subject>Blood pressure</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Enzymes</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - metabolism</subject><subject>Insulin</subject><subject>Insulin resistance</subject><subject>Male</subject><subject>Matrix Metalloproteinase 2 - blood</subject><subject>Matrix Metalloproteinase 2 - metabolism</subject><subject>Metabolism, Inborn Errors - complications</subject><subject>Metabolism, Inborn Errors - metabolism</subject><subject>Obesity</subject><subject>Pathogenesis</subject><subject>Pediatric Obesity - complications</subject><subject>Pediatric Obesity - metabolism</subject><subject>Ratios</subject><subject>Regression Analysis</subject><subject>Teenagers</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - blood</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKAzEYhuEgiq3VhTcgATe6aJvDnLLU4qHQUhcKuhoymX9oynRSk2nL7LwEr9ErMbW1C8FVQnh4CR9C55T0KCGsb7Kmx4jg4gC1qeCkG3Pxeri_J7SFTpybERJEJKTHqMXCgMQ8ZG2khpWyIB3kWKpar3TdYFPg8fjp6-OTYV3habMAW0Pl9AqwycABVlNd5hYqrB2WzhmlZe0Da11PN9zIXC9MBb5XwVzLU3RUyNLB2e7soJf7u-fBY3c0eRgObkZdxUMuugXjSZxHlEWQx_6jHAqWQSxEAmHGRSjigvs3QYKEhJHgkMkiDhTPopwlEcl5B11tuwtr3pfg6nSunYKylBWYpUtpFBDOEiaEp5d_6MwsbeV_51UcChpQlnh1vVXKGucsFOnC6rm0TUpJulk-9cunP8t7e7ErLrM55Hv5O7UH_S1Y6xKa_0vp5PZtm_wGL_GN0Q</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Belo, Vanessa A.</creator><creator>Lacchini, Riccardo</creator><creator>Miranda, Josiane A.</creator><creator>Lanna, Carla M.M.</creator><creator>Souza‐Costa, Debora C.</creator><creator>Tanus‐Santos, Jose E.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>Increased activity of MMP‐2 in hypertensive obese children is associated with hypoadiponectinemia</title><author>Belo, Vanessa A. ; Lacchini, Riccardo ; Miranda, Josiane A. ; Lanna, Carla M.M. ; Souza‐Costa, Debora C. ; Tanus‐Santos, Jose E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3539-f2387d6126ed76053ef2be7998e5b39597f33ef904805693ebaf74c3b6d2860d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adiponectin - deficiency</topic><topic>Adiponectin - metabolism</topic><topic>Adolescent</topic><topic>Atherosclerosis</topic><topic>Bands</topic><topic>Bioavailability</topic><topic>Blood pressure</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Enzymes</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension - complications</topic><topic>Hypertension - metabolism</topic><topic>Insulin</topic><topic>Insulin resistance</topic><topic>Male</topic><topic>Matrix Metalloproteinase 2 - blood</topic><topic>Matrix Metalloproteinase 2 - metabolism</topic><topic>Metabolism, Inborn Errors - complications</topic><topic>Metabolism, Inborn Errors - metabolism</topic><topic>Obesity</topic><topic>Pathogenesis</topic><topic>Pediatric Obesity - complications</topic><topic>Pediatric Obesity - metabolism</topic><topic>Ratios</topic><topic>Regression Analysis</topic><topic>Teenagers</topic><topic>Tissue Inhibitor of Metalloproteinase-2 - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belo, Vanessa A.</creatorcontrib><creatorcontrib>Lacchini, Riccardo</creatorcontrib><creatorcontrib>Miranda, Josiane A.</creatorcontrib><creatorcontrib>Lanna, Carla M.M.</creatorcontrib><creatorcontrib>Souza‐Costa, Debora C.</creatorcontrib><creatorcontrib>Tanus‐Santos, Jose E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belo, Vanessa A.</au><au>Lacchini, Riccardo</au><au>Miranda, Josiane A.</au><au>Lanna, Carla M.M.</au><au>Souza‐Costa, Debora C.</au><au>Tanus‐Santos, Jose E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased activity of MMP‐2 in hypertensive obese children is associated with hypoadiponectinemia</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2015-01</date><risdate>2015</risdate><volume>23</volume><issue>1</issue><spage>177</spage><epage>182</epage><pages>177-182</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
To compare the circulating levels of MMP‐2 and TIMP‐2 and the MMP‐2/TIMP‐2 ratio in control, obese, and obese hypertensive children and adolescents and to assess whether hypoadiponectinemia is associated with MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Methods
Studies were carried out with 53 control, 73 obese, and 29 obese hypertensive children and adolescents in this cross‐sectional study. Adiponectin and TIMP‐2 concentrations were measured by ELISA. MMP‐2 concentrations were measured by gelatin zymography. Multiple linear regression analysis was carried out to assess the effects of adiponectin on MMP‐2 and TIMP‐2 levels and MMP‐2/TIMP‐2 ratios.
Results
The obese hypertensive group had the lowest adiponectin levels among groups (P < 0.05) while obese subjects had lower adiponectin levels than control subjects (P < 0.05). Obese hypertensive subjects also had higher circulating MMP‐2 concentrations than obese subjects (P < 0.05) and had the highest MMP‐2/TIMP‐2 ratios among groups (P < 0.05). Moreover, obese/hypertensive subjects had the lowest TIMP‐2 levels among groups (P < 0.05). A multiple linear regression analysis showed that MMP‐2 levels and MMP‐2/TIMP‐2 ratios are negatively associated with adiponectin levels (P = 0.034 and P = 0.011, respectively) while TIMP‐2 levels is positively associated with adiponectin levels (P = 0.013).
Conclusions
Increased activity of MMP‐2 (MMP‐2/TIMP‐2 ratio) and reduced TIMP‐2 levels may play an important role in clinical hypertension of childhood obesity. Additionally, hypoadiponectinemia may contribute to increased activity of MMP‐2 in obese/hypertensive children and adolescents.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>25407352</pmid><doi>10.1002/oby.20939</doi><tpages>6</tpages></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2015-01, Vol.23 (1), p.177-182 |
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| source | MEDLINE; Wiley Free Content; Wiley Online Library All Journals |
| subjects | Adiponectin - deficiency Adiponectin - metabolism Adolescent Atherosclerosis Bands Bioavailability Blood pressure Case-Control Studies Child Cross-Sectional Studies Diabetes Endocrinology Enzyme-Linked Immunosorbent Assay Enzymes Female Humans Hypertension Hypertension - complications Hypertension - metabolism Insulin Insulin resistance Male Matrix Metalloproteinase 2 - blood Matrix Metalloproteinase 2 - metabolism Metabolism, Inborn Errors - complications Metabolism, Inborn Errors - metabolism Obesity Pathogenesis Pediatric Obesity - complications Pediatric Obesity - metabolism Ratios Regression Analysis Teenagers Tissue Inhibitor of Metalloproteinase-2 - blood |
| title | Increased activity of MMP‐2 in hypertensive obese children is associated with hypoadiponectinemia |
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