The acute effects of daily nicotine intake on heart rate – A toxicokinetic and toxicodynamic modelling study

•We calibrate and validate the refined PBTK-TD models on literature in vivo studies of nicotine.•We apply the models to simulate selected profiles of human daily exposure to nicotine.•We estimate effects of nicotine on the acute increase of heart rate at rest and during exercise.•We compare the toxi...

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Veröffentlicht in:	Regulatory toxicology and pharmacology 2014-10, Vol.70 (1), p.312-324
Hauptverfasser:	Gajewska, M., Worth, A., Urani, C., Briesen, H., Schramm, K.-W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Administration, Oral Adult Area Under Curve Calibration Exercise - physiology Heart Rate - drug effects Humans Male Models, Biological Nicotine Nicotine - administration & dosage Nicotine - pharmacokinetics Nicotine - toxicity Physiologically-based toxicodynamic (PBTD) modelling Physiologically-based toxicokinetic (PBTK) modelling Skin Absorption Smoking - adverse effects Smoking - metabolism Tissue Distribution Tobacco Use Cessation Products Transdermal Patch
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