Toxicology and the chemical foundation of plants of Erycibe
[Display omitted] •This is the first report on the chemical foundation of plants of Erycibe.•This is the first report on the toxicology of total alkaloid and Baogongteng C.•The work firstly developed a HPLC–MS method using for the analysis of Baogongteng A and Baogongteng C. Erycibe is a relatively...
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| Veröffentlicht in: | Regulatory toxicology and pharmacology 2014-10, Vol.70 (1), p.349-356 |
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| creator | Chen, Zhiyong Wang, Li Liao, Liping Zhang, Zijia Wang, Zhengtao |
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•This is the first report on the chemical foundation of plants of Erycibe.•This is the first report on the toxicology of total alkaloid and Baogongteng C.•The work firstly developed a HPLC–MS method using for the analysis of Baogongteng A and Baogongteng C.
Erycibe is a relatively small genus in the family Convolvulaceae with over 10 identified species. Some Erycibe plant species are purportedly toxic at high doses. However, few toxicology studies have been conducted on those species. In this study, the toxicity of 40% ethanolic extracts of Erycibe obtusifolia, Erycibe schmidtii, and Erycibe ellipptimba was evaluated. E. ellipptimba has been reported to be more toxic due to containing larger amounts of Baogongteng C, an alkaloid with known toxicity. Thus, E. ellipptimba was chosen for further toxicology study here. An HPLC–MS method was developed to identify the main components and determine the percentages of Baogongteng C in total alkaloid of E. ellipptimba (EWA). The toxicity of total alkaloid and Baogongteng C was evaluated and compared. The results indicated that Baogongteng A and Baogongteng C are the major toxic chemical compounds of the Erycibe species tested. The results also suggest EWA is cholinergic. Finally, in a subacute toxicity study of EWA, alterations observed with high dosage suggest that the liver and kidney could be the target organs of toxicity. |
| doi_str_mv | 10.1016/j.yrtph.2014.07.019 |
| format | Article |
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•This is the first report on the chemical foundation of plants of Erycibe.•This is the first report on the toxicology of total alkaloid and Baogongteng C.•The work firstly developed a HPLC–MS method using for the analysis of Baogongteng A and Baogongteng C.
Erycibe is a relatively small genus in the family Convolvulaceae with over 10 identified species. Some Erycibe plant species are purportedly toxic at high doses. However, few toxicology studies have been conducted on those species. In this study, the toxicity of 40% ethanolic extracts of Erycibe obtusifolia, Erycibe schmidtii, and Erycibe ellipptimba was evaluated. E. ellipptimba has been reported to be more toxic due to containing larger amounts of Baogongteng C, an alkaloid with known toxicity. Thus, E. ellipptimba was chosen for further toxicology study here. An HPLC–MS method was developed to identify the main components and determine the percentages of Baogongteng C in total alkaloid of E. ellipptimba (EWA). The toxicity of total alkaloid and Baogongteng C was evaluated and compared. The results indicated that Baogongteng A and Baogongteng C are the major toxic chemical compounds of the Erycibe species tested. The results also suggest EWA is cholinergic. Finally, in a subacute toxicity study of EWA, alterations observed with high dosage suggest that the liver and kidney could be the target organs of toxicity.</description><identifier>ISSN: 0273-2300</identifier><identifier>EISSN: 1096-0295</identifier><identifier>DOI: 10.1016/j.yrtph.2014.07.019</identifier><identifier>PMID: 25073109</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Acute toxicity ; Alkaloids - isolation & purification ; Alkaloids - toxicity ; Animals ; Baogongteng A ; Baogongteng C ; Chromatography, High Pressure Liquid - methods ; Convolvulaceae ; Convolvulaceae - chemistry ; Dose-Response Relationship, Drug ; Erycibe ; Erycibe ellipptimba ; Erycibe obtusifolia ; Erycibe schmidtii ; Female ; Male ; Mass Spectrometry - methods ; Mice ; Mice, Inbred ICR ; Plant Extracts - administration & dosage ; Plant Extracts - toxicity ; Rats ; Rats, Sprague-Dawley ; Species Specificity ; Subacute toxicity ; Tropanes - isolation & purification ; Tropanes - toxicity</subject><ispartof>Regulatory toxicology and pharmacology, 2014-10, Vol.70 (1), p.349-356</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-cc6bd22d5623f04ba81c4dadc10693125ef13c8d06c630bb3c0350c465341dd3</citedby><cites>FETCH-LOGICAL-c392t-cc6bd22d5623f04ba81c4dadc10693125ef13c8d06c630bb3c0350c465341dd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0273230014001743$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25073109$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zhiyong</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Liao, Liping</creatorcontrib><creatorcontrib>Zhang, Zijia</creatorcontrib><creatorcontrib>Wang, Zhengtao</creatorcontrib><title>Toxicology and the chemical foundation of plants of Erycibe</title><title>Regulatory toxicology and pharmacology</title><addtitle>Regul Toxicol Pharmacol</addtitle><description>[Display omitted]
•This is the first report on the chemical foundation of plants of Erycibe.•This is the first report on the toxicology of total alkaloid and Baogongteng C.•The work firstly developed a HPLC–MS method using for the analysis of Baogongteng A and Baogongteng C.
Erycibe is a relatively small genus in the family Convolvulaceae with over 10 identified species. Some Erycibe plant species are purportedly toxic at high doses. However, few toxicology studies have been conducted on those species. In this study, the toxicity of 40% ethanolic extracts of Erycibe obtusifolia, Erycibe schmidtii, and Erycibe ellipptimba was evaluated. E. ellipptimba has been reported to be more toxic due to containing larger amounts of Baogongteng C, an alkaloid with known toxicity. Thus, E. ellipptimba was chosen for further toxicology study here. An HPLC–MS method was developed to identify the main components and determine the percentages of Baogongteng C in total alkaloid of E. ellipptimba (EWA). The toxicity of total alkaloid and Baogongteng C was evaluated and compared. The results indicated that Baogongteng A and Baogongteng C are the major toxic chemical compounds of the Erycibe species tested. The results also suggest EWA is cholinergic. Finally, in a subacute toxicity study of EWA, alterations observed with high dosage suggest that the liver and kidney could be the target organs of toxicity.</description><subject>Acute toxicity</subject><subject>Alkaloids - isolation & purification</subject><subject>Alkaloids - toxicity</subject><subject>Animals</subject><subject>Baogongteng A</subject><subject>Baogongteng C</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Convolvulaceae</subject><subject>Convolvulaceae - chemistry</subject><subject>Dose-Response Relationship, Drug</subject><subject>Erycibe</subject><subject>Erycibe ellipptimba</subject><subject>Erycibe obtusifolia</subject><subject>Erycibe schmidtii</subject><subject>Female</subject><subject>Male</subject><subject>Mass Spectrometry - methods</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - toxicity</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Species Specificity</subject><subject>Subacute toxicity</subject><subject>Tropanes - isolation & purification</subject><subject>Tropanes - toxicity</subject><issn>0273-2300</issn><issn>1096-0295</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1PwzAQhi0EoqXwC5BQRpaEs504iRADqsqHVImlu5WcHeoqiYOdIPLvSWlhZLobnvc-HkKuKUQUqLjbRaPru23EgMYRpBHQ_ITMKeQiBJYnp2QOLOUh4wAzcuH9DgBYlqXnZMYSSPlEzsn9xn4ZtLV9H4OiVUG_1QFudWOwqIPKDq0qemPbwFZBVxdt7_fdyo1oSn1Jzqqi9vrqWBdk87TaLF_C9dvz6_JxHSLPWR8iilIxphLBeAVxWWQUY1UopCByTlmiK8oxUyBQcChLjsATwFgkPKZK8QW5PYztnP0YtO9lYzzqejpH28FLKnie5yJN6ITyA4rOeu90JTtnmsKNkoLcS5M7-SNN7qVJSOUkbUrdHBcMZaPVX-bX0gQ8HAA9fflptJMejW5RK-M09lJZ8--Cb2-9ff0</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Chen, Zhiyong</creator><creator>Wang, Li</creator><creator>Liao, Liping</creator><creator>Zhang, Zijia</creator><creator>Wang, Zhengtao</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20141001</creationdate><title>Toxicology and the chemical foundation of plants of Erycibe</title><author>Chen, Zhiyong ; Wang, Li ; Liao, Liping ; Zhang, Zijia ; Wang, Zhengtao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-cc6bd22d5623f04ba81c4dadc10693125ef13c8d06c630bb3c0350c465341dd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Acute toxicity</topic><topic>Alkaloids - isolation & purification</topic><topic>Alkaloids - toxicity</topic><topic>Animals</topic><topic>Baogongteng A</topic><topic>Baogongteng C</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Convolvulaceae</topic><topic>Convolvulaceae - chemistry</topic><topic>Dose-Response Relationship, Drug</topic><topic>Erycibe</topic><topic>Erycibe ellipptimba</topic><topic>Erycibe obtusifolia</topic><topic>Erycibe schmidtii</topic><topic>Female</topic><topic>Male</topic><topic>Mass Spectrometry - methods</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - toxicity</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Species Specificity</topic><topic>Subacute toxicity</topic><topic>Tropanes - isolation & purification</topic><topic>Tropanes - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zhiyong</creatorcontrib><creatorcontrib>Wang, Li</creatorcontrib><creatorcontrib>Liao, Liping</creatorcontrib><creatorcontrib>Zhang, Zijia</creatorcontrib><creatorcontrib>Wang, Zhengtao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Regulatory toxicology and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zhiyong</au><au>Wang, Li</au><au>Liao, Liping</au><au>Zhang, Zijia</au><au>Wang, Zhengtao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Toxicology and the chemical foundation of plants of Erycibe</atitle><jtitle>Regulatory toxicology and pharmacology</jtitle><addtitle>Regul Toxicol Pharmacol</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>70</volume><issue>1</issue><spage>349</spage><epage>356</epage><pages>349-356</pages><issn>0273-2300</issn><eissn>1096-0295</eissn><abstract>[Display omitted]
•This is the first report on the chemical foundation of plants of Erycibe.•This is the first report on the toxicology of total alkaloid and Baogongteng C.•The work firstly developed a HPLC–MS method using for the analysis of Baogongteng A and Baogongteng C.
Erycibe is a relatively small genus in the family Convolvulaceae with over 10 identified species. Some Erycibe plant species are purportedly toxic at high doses. However, few toxicology studies have been conducted on those species. In this study, the toxicity of 40% ethanolic extracts of Erycibe obtusifolia, Erycibe schmidtii, and Erycibe ellipptimba was evaluated. E. ellipptimba has been reported to be more toxic due to containing larger amounts of Baogongteng C, an alkaloid with known toxicity. Thus, E. ellipptimba was chosen for further toxicology study here. An HPLC–MS method was developed to identify the main components and determine the percentages of Baogongteng C in total alkaloid of E. ellipptimba (EWA). The toxicity of total alkaloid and Baogongteng C was evaluated and compared. The results indicated that Baogongteng A and Baogongteng C are the major toxic chemical compounds of the Erycibe species tested. The results also suggest EWA is cholinergic. Finally, in a subacute toxicity study of EWA, alterations observed with high dosage suggest that the liver and kidney could be the target organs of toxicity.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>25073109</pmid><doi>10.1016/j.yrtph.2014.07.019</doi><tpages>8</tpages></addata></record> |
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| subjects | Acute toxicity Alkaloids - isolation & purification Alkaloids - toxicity Animals Baogongteng A Baogongteng C Chromatography, High Pressure Liquid - methods Convolvulaceae Convolvulaceae - chemistry Dose-Response Relationship, Drug Erycibe Erycibe ellipptimba Erycibe obtusifolia Erycibe schmidtii Female Male Mass Spectrometry - methods Mice Mice, Inbred ICR Plant Extracts - administration & dosage Plant Extracts - toxicity Rats Rats, Sprague-Dawley Species Specificity Subacute toxicity Tropanes - isolation & purification Tropanes - toxicity |
| title | Toxicology and the chemical foundation of plants of Erycibe |
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