New role of lupeol in reticence of angiogenesis, the cellular parameter of neoplastic progression in tumorigenesis models through altered gene expression

•Antiangiogenesis effect of the lupeol was studied in tumerogenic and non tumerogenic models.•Lupeol induces antiangiogenesis and thereby regress the tumor growth.•Lupeol is responsible for the differential angiogenic gene expression by altering the levels of MMP-2 & -9, VEGFa, HIF-1α, and flt-1...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-05, Vol.448 (2), p.139-144
Hauptverfasser:	Vijay Avin, B.R., Prabhu, T., Ramesh, C.K., Vigneshwaran, V., Riaz, Mahmood, Jayashree, K., Prabhakar, B.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Antiangiogenesis Chick Embryo Chorioallantoic Membrane - blood supply Chorioallantoic Membrane - drug effects Chorioallantoic Membrane - pathology Cornea - blood supply Cornea - drug effects Gene Expression Regulation - drug effects Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Lupeol Lymphoma - drug therapy Lymphoma - pathology Male Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 9 - genetics Mice Neovascularization Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - genetics Pentacyclic Triterpenes - pharmacology Rats Vascular Endothelial Growth Factor A - genetics VEGF Xenograft Model Antitumor Assays
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