‘Post‐LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection
ABSTRACT Objectives To review the fetal echocardiograms of patients with total anomalous pulmonary venous connection (TAPVC) in order to determine whether the distance between the left atrium and the descending aorta would be useful in the prenatal diagnosis of fetal TAPVC. Methods We reviewed the f...
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| Veröffentlicht in: | Ultrasound in obstetrics & gynecology 2014-12, Vol.44 (6), p.682-687 |
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| container_title | Ultrasound in obstetrics & gynecology |
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| creator | Kawazu, Y. Inamura, N. Shiono, N. Kanagawa, N. Narita, J. Hamamichi, Y. Kayatani, F. |
| description | ABSTRACT
Objectives
To review the fetal echocardiograms of patients with total anomalous pulmonary venous connection (TAPVC) in order to determine whether the distance between the left atrium and the descending aorta would be useful in the prenatal diagnosis of fetal TAPVC.
Methods
We reviewed the fetal echocardiograms of eight cases of TAPVC (five supracardiac type and three infracardiac type) with no other cardiac malformations. We evaluated the ratio of the left atrium–descending aorta distance to the diameter of the descending aorta (‘post‐LA space index’) in 101 normal and eight TAPVC fetuses, and compared the values between groups. In addition, we examined the tricuspid valve/mitral valve diameter ratio (TVD/MVD) and the right ventricular end‐diastolic diameter/left ventricular end‐diastolic diameter ratio (RVDd/LVDd).
Results
The echocardiograms for fetuses with TAPVC and normal fetuses were performed at mean gestational ages of 27.5 weeks and 29.6 weeks, respectively. There were no significant differences in the TVD/MVD and RVDd/LVDd ratios between the groups. However, the post‐LA space index was significantly higher in the TAPVC cases (mean, 1.51) than it was in the normal fetuses (mean, 0.71 ± 0.23) (P 1.27. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd. |
| doi_str_mv | 10.1002/uog.13357 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1639995153</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1639995153</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4877-ffd6c6e95ebe3ce1d10889ce4029ed01fc707207bb391fbc7ba91e91b24614b33</originalsourceid><addsrcrecordid>eNqN0TFv1DAUB3ALgehRGPgCyBILDGmfE8c-j1UFBemkMtA5cpyX4uLYwU5abru5U0f4evdJ8PUKAxISkyW_n_7y85-QlwyOGEB5PIfLI1ZVtXxEFowLVYCE-jFZgBJQSKHKA_IspSsAELwST8lByQXwWsoFud1ufnwKadpu7lYnNI3aILW-w-_bzU-qE9V0DBP6yWpHfbhGRwcdv2KkfYh0-oJ0jOj1lKed1Zc-JJto6KlNwekJOzqF3Uz7MGgX5kTH2Q3B67im1-h3FyZ4j2aywT8nT3rtEr54OA_Jxft3n08_FKvzs4-nJ6vC8KWURd93wghUNbZYGWQdg-VSGeRQKuyA9UaCLEG2baVY3xrZasVQsTYvzXhbVYfkzT53jOHbjGlqBpsMOqc95hc1TFRKqZrV_0PLLLlY1pm-_otehTn6vMi9Aq6YkFm93SsTQ0oR-2aMNv_oumHQ7LpscpfNfZfZvnpInNsBuz_yd3kZHO_BjXW4_ndSc3F-to_8BWaHrQ0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1629049167</pqid></control><display><type>article</type><title>‘Post‐LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection</title><source>MEDLINE</source><source>Wiley Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><creator>Kawazu, Y. ; Inamura, N. ; Shiono, N. ; Kanagawa, N. ; Narita, J. ; Hamamichi, Y. ; Kayatani, F.</creator><creatorcontrib>Kawazu, Y. ; Inamura, N. ; Shiono, N. ; Kanagawa, N. ; Narita, J. ; Hamamichi, Y. ; Kayatani, F.</creatorcontrib><description>ABSTRACT
Objectives
To review the fetal echocardiograms of patients with total anomalous pulmonary venous connection (TAPVC) in order to determine whether the distance between the left atrium and the descending aorta would be useful in the prenatal diagnosis of fetal TAPVC.
Methods
We reviewed the fetal echocardiograms of eight cases of TAPVC (five supracardiac type and three infracardiac type) with no other cardiac malformations. We evaluated the ratio of the left atrium–descending aorta distance to the diameter of the descending aorta (‘post‐LA space index’) in 101 normal and eight TAPVC fetuses, and compared the values between groups. In addition, we examined the tricuspid valve/mitral valve diameter ratio (TVD/MVD) and the right ventricular end‐diastolic diameter/left ventricular end‐diastolic diameter ratio (RVDd/LVDd).
Results
The echocardiograms for fetuses with TAPVC and normal fetuses were performed at mean gestational ages of 27.5 weeks and 29.6 weeks, respectively. There were no significant differences in the TVD/MVD and RVDd/LVDd ratios between the groups. However, the post‐LA space index was significantly higher in the TAPVC cases (mean, 1.51) than it was in the normal fetuses (mean, 0.71 ± 0.23) (P < 0.0001). On an analysis of the receiver–operating characteristics curve, a post‐LA space index cut‐off of 1.27 was found to be optimal for distinguishing between TAPVC and normal hearts, with a sensitivity of 100% and specificity of 99%.
Conclusions
The novel post‐LA space index could potentially be used for the prenatal diagnosis of TAPVC. A diagnosis of TAPVC is very likely in cases with a post‐LA space index of > 1.27. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.</description><identifier>ISSN: 0960-7692</identifier><identifier>EISSN: 1469-0705</identifier><identifier>DOI: 10.1002/uog.13357</identifier><identifier>PMID: 24604577</identifier><identifier>CODEN: UOGYFJ</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Aorta, Thoracic - diagnostic imaging ; Aorta, Thoracic - embryology ; congenital heart disease ; Female ; fetal echocardiogram ; Heart Atria - diagnostic imaging ; Heart Atria - embryology ; Heart Valves - diagnostic imaging ; Heart Valves - embryology ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - embryology ; Humans ; Pregnancy ; Pregnancy Trimester, Third ; prenatal diagnosis ; Retrospective Studies ; ROC Curve ; Scimitar Syndrome - diagnostic imaging ; total anomalous pulmonary venous connection ; Ultrasonography, Prenatal</subject><ispartof>Ultrasound in obstetrics & gynecology, 2014-12, Vol.44 (6), p.682-687</ispartof><rights>Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd</rights><rights>Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4877-ffd6c6e95ebe3ce1d10889ce4029ed01fc707207bb391fbc7ba91e91b24614b33</citedby><cites>FETCH-LOGICAL-c4877-ffd6c6e95ebe3ce1d10889ce4029ed01fc707207bb391fbc7ba91e91b24614b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fuog.13357$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fuog.13357$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24604577$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawazu, Y.</creatorcontrib><creatorcontrib>Inamura, N.</creatorcontrib><creatorcontrib>Shiono, N.</creatorcontrib><creatorcontrib>Kanagawa, N.</creatorcontrib><creatorcontrib>Narita, J.</creatorcontrib><creatorcontrib>Hamamichi, Y.</creatorcontrib><creatorcontrib>Kayatani, F.</creatorcontrib><title>‘Post‐LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection</title><title>Ultrasound in obstetrics & gynecology</title><addtitle>Ultrasound Obstet Gynecol</addtitle><description>ABSTRACT
Objectives
To review the fetal echocardiograms of patients with total anomalous pulmonary venous connection (TAPVC) in order to determine whether the distance between the left atrium and the descending aorta would be useful in the prenatal diagnosis of fetal TAPVC.
Methods
We reviewed the fetal echocardiograms of eight cases of TAPVC (five supracardiac type and three infracardiac type) with no other cardiac malformations. We evaluated the ratio of the left atrium–descending aorta distance to the diameter of the descending aorta (‘post‐LA space index’) in 101 normal and eight TAPVC fetuses, and compared the values between groups. In addition, we examined the tricuspid valve/mitral valve diameter ratio (TVD/MVD) and the right ventricular end‐diastolic diameter/left ventricular end‐diastolic diameter ratio (RVDd/LVDd).
Results
The echocardiograms for fetuses with TAPVC and normal fetuses were performed at mean gestational ages of 27.5 weeks and 29.6 weeks, respectively. There were no significant differences in the TVD/MVD and RVDd/LVDd ratios between the groups. However, the post‐LA space index was significantly higher in the TAPVC cases (mean, 1.51) than it was in the normal fetuses (mean, 0.71 ± 0.23) (P < 0.0001). On an analysis of the receiver–operating characteristics curve, a post‐LA space index cut‐off of 1.27 was found to be optimal for distinguishing between TAPVC and normal hearts, with a sensitivity of 100% and specificity of 99%.
Conclusions
The novel post‐LA space index could potentially be used for the prenatal diagnosis of TAPVC. A diagnosis of TAPVC is very likely in cases with a post‐LA space index of > 1.27. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.</description><subject>Aorta, Thoracic - diagnostic imaging</subject><subject>Aorta, Thoracic - embryology</subject><subject>congenital heart disease</subject><subject>Female</subject><subject>fetal echocardiogram</subject><subject>Heart Atria - diagnostic imaging</subject><subject>Heart Atria - embryology</subject><subject>Heart Valves - diagnostic imaging</subject><subject>Heart Valves - embryology</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - embryology</subject><subject>Humans</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, Third</subject><subject>prenatal diagnosis</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Scimitar Syndrome - diagnostic imaging</subject><subject>total anomalous pulmonary venous connection</subject><subject>Ultrasonography, Prenatal</subject><issn>0960-7692</issn><issn>1469-0705</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0TFv1DAUB3ALgehRGPgCyBILDGmfE8c-j1UFBemkMtA5cpyX4uLYwU5abru5U0f4evdJ8PUKAxISkyW_n_7y85-QlwyOGEB5PIfLI1ZVtXxEFowLVYCE-jFZgBJQSKHKA_IspSsAELwST8lByQXwWsoFud1ufnwKadpu7lYnNI3aILW-w-_bzU-qE9V0DBP6yWpHfbhGRwcdv2KkfYh0-oJ0jOj1lKed1Zc-JJto6KlNwekJOzqF3Uz7MGgX5kTH2Q3B67im1-h3FyZ4j2aywT8nT3rtEr54OA_Jxft3n08_FKvzs4-nJ6vC8KWURd93wghUNbZYGWQdg-VSGeRQKuyA9UaCLEG2baVY3xrZasVQsTYvzXhbVYfkzT53jOHbjGlqBpsMOqc95hc1TFRKqZrV_0PLLLlY1pm-_otehTn6vMi9Aq6YkFm93SsTQ0oR-2aMNv_oumHQ7LpscpfNfZfZvnpInNsBuz_yd3kZHO_BjXW4_ndSc3F-to_8BWaHrQ0</recordid><startdate>201412</startdate><enddate>201412</enddate><creator>Kawazu, Y.</creator><creator>Inamura, N.</creator><creator>Shiono, N.</creator><creator>Kanagawa, N.</creator><creator>Narita, J.</creator><creator>Hamamichi, Y.</creator><creator>Kayatani, F.</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201412</creationdate><title>‘Post‐LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection</title><author>Kawazu, Y. ; Inamura, N. ; Shiono, N. ; Kanagawa, N. ; Narita, J. ; Hamamichi, Y. ; Kayatani, F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4877-ffd6c6e95ebe3ce1d10889ce4029ed01fc707207bb391fbc7ba91e91b24614b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aorta, Thoracic - diagnostic imaging</topic><topic>Aorta, Thoracic - embryology</topic><topic>congenital heart disease</topic><topic>Female</topic><topic>fetal echocardiogram</topic><topic>Heart Atria - diagnostic imaging</topic><topic>Heart Atria - embryology</topic><topic>Heart Valves - diagnostic imaging</topic><topic>Heart Valves - embryology</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - embryology</topic><topic>Humans</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, Third</topic><topic>prenatal diagnosis</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Scimitar Syndrome - diagnostic imaging</topic><topic>total anomalous pulmonary venous connection</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawazu, Y.</creatorcontrib><creatorcontrib>Inamura, N.</creatorcontrib><creatorcontrib>Shiono, N.</creatorcontrib><creatorcontrib>Kanagawa, N.</creatorcontrib><creatorcontrib>Narita, J.</creatorcontrib><creatorcontrib>Hamamichi, Y.</creatorcontrib><creatorcontrib>Kayatani, F.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in obstetrics & gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawazu, Y.</au><au>Inamura, N.</au><au>Shiono, N.</au><au>Kanagawa, N.</au><au>Narita, J.</au><au>Hamamichi, Y.</au><au>Kayatani, F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>‘Post‐LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection</atitle><jtitle>Ultrasound in obstetrics & gynecology</jtitle><addtitle>Ultrasound Obstet Gynecol</addtitle><date>2014-12</date><risdate>2014</risdate><volume>44</volume><issue>6</issue><spage>682</spage><epage>687</epage><pages>682-687</pages><issn>0960-7692</issn><eissn>1469-0705</eissn><coden>UOGYFJ</coden><abstract>ABSTRACT
Objectives
To review the fetal echocardiograms of patients with total anomalous pulmonary venous connection (TAPVC) in order to determine whether the distance between the left atrium and the descending aorta would be useful in the prenatal diagnosis of fetal TAPVC.
Methods
We reviewed the fetal echocardiograms of eight cases of TAPVC (five supracardiac type and three infracardiac type) with no other cardiac malformations. We evaluated the ratio of the left atrium–descending aorta distance to the diameter of the descending aorta (‘post‐LA space index’) in 101 normal and eight TAPVC fetuses, and compared the values between groups. In addition, we examined the tricuspid valve/mitral valve diameter ratio (TVD/MVD) and the right ventricular end‐diastolic diameter/left ventricular end‐diastolic diameter ratio (RVDd/LVDd).
Results
The echocardiograms for fetuses with TAPVC and normal fetuses were performed at mean gestational ages of 27.5 weeks and 29.6 weeks, respectively. There were no significant differences in the TVD/MVD and RVDd/LVDd ratios between the groups. However, the post‐LA space index was significantly higher in the TAPVC cases (mean, 1.51) than it was in the normal fetuses (mean, 0.71 ± 0.23) (P < 0.0001). On an analysis of the receiver–operating characteristics curve, a post‐LA space index cut‐off of 1.27 was found to be optimal for distinguishing between TAPVC and normal hearts, with a sensitivity of 100% and specificity of 99%.
Conclusions
The novel post‐LA space index could potentially be used for the prenatal diagnosis of TAPVC. A diagnosis of TAPVC is very likely in cases with a post‐LA space index of > 1.27. Copyright © 2014 ISUOG. Published by John Wiley & Sons Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>24604577</pmid><doi>10.1002/uog.13357</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aorta, Thoracic - diagnostic imaging Aorta, Thoracic - embryology congenital heart disease Female fetal echocardiogram Heart Atria - diagnostic imaging Heart Atria - embryology Heart Valves - diagnostic imaging Heart Valves - embryology Heart Ventricles - diagnostic imaging Heart Ventricles - embryology Humans Pregnancy Pregnancy Trimester, Third prenatal diagnosis Retrospective Studies ROC Curve Scimitar Syndrome - diagnostic imaging total anomalous pulmonary venous connection Ultrasonography, Prenatal |
| title | ‘Post‐LA space index’ as a potential novel marker for the prenatal diagnosis of isolated total anomalous pulmonary venous connection |
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