Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis
Increased CD143 activity has been detected in various skin tissues, and this increase is partially caused by the intronic ID polymorphism. The genetic contribution of CD143 ID polymorphism to the progression of psoriasis, the commonest skin disease, has been extensively investigated, but reported wi...
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| Veröffentlicht in: | Cell biochemistry and biophysics 2014-12, Vol.70 (3), p.1617-1623 |
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| creator | Xia, Tianbao Diao, Jinfu Huang, He Li, Jie Sun, Lei Li, Hengjin Lv, Shichao |
| description | Increased CD143 activity has been detected in various skin tissues, and this increase is partially caused by the intronic ID polymorphism. The genetic contribution of CD143 ID polymorphism to the progression of psoriasis, the commonest skin disease, has been extensively investigated, but reported with inconsistent results. The aim of this work was to gain new insights to shed light on the association between CD143 ID polymorphism and psoriasis risk. We systematically identified the studies examining the association of CD143 ID polymorphism with psoriasis risk. A meta-analysis combining data from all eligible studies was carried out. To evaluate the genetic association, we calculated odds ratio (OR) and its 95 % confidence intervals (CIs) for both genotypic models and allelic model. The final pooling dataset comprised ten studies. Meta-analysis of total samples did not suggest a notable association with psoriasis risk. However, subgroup analysis by ethnicity revealed a statistically significant association in East Asian samples (DD + ID vs. II: OR 0.86, 95 % CI 0.75–0.99, P
heterogeneity
= 0.970; DD vs. ID: OR 0.85, 95 % CI 0.73–0.99, P
heterogeneity
= 0.868; D vs. I: OR 0.86, 95 % CI 0.76–0.97, P
heterogeneity
= 0.994). This meta-analysis demonstrated that the presence of CD143 ID polymorphism may modify the risk of psoriasis in individuals with East Asian ancestry. |
| doi_str_mv | 10.1007/s12013-014-0104-4 |
| format | Article |
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heterogeneity
= 0.970; DD vs. ID: OR 0.85, 95 % CI 0.73–0.99, P
heterogeneity
= 0.868; D vs. I: OR 0.86, 95 % CI 0.76–0.97, P
heterogeneity
= 0.994). This meta-analysis demonstrated that the presence of CD143 ID polymorphism may modify the risk of psoriasis in individuals with East Asian ancestry.</description><identifier>ISSN: 1085-9195</identifier><identifier>EISSN: 1559-0283</identifier><identifier>DOI: 10.1007/s12013-014-0104-4</identifier><identifier>PMID: 24997622</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Asian Continental Ancestry Group - statistics & numerical data ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Biotechnology ; Cell Biology ; Female ; Genetic Association Studies ; Genetic Markers - genetics ; Genetic Predisposition to Disease - epidemiology ; Genetic Predisposition to Disease - genetics ; Heterogeneity ; Humans ; Life Sciences ; Male ; Original Paper ; Peptidyl-Dipeptidase A - genetics ; Pharmacology/Toxicology ; Polymorphism, Single Nucleotide - genetics ; Prevalence ; Psoriasis ; Psoriasis - epidemiology ; Psoriasis - genetics ; Risk Factors ; Skin diseases</subject><ispartof>Cell biochemistry and biophysics, 2014-12, Vol.70 (3), p.1617-1623</ispartof><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-b3ebd5e24b01380094cf65dc4e436ebdac76943a82deafe98e3546d153863b5a3</citedby><cites>FETCH-LOGICAL-c405t-b3ebd5e24b01380094cf65dc4e436ebdac76943a82deafe98e3546d153863b5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12013-014-0104-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12013-014-0104-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24997622$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xia, Tianbao</creatorcontrib><creatorcontrib>Diao, Jinfu</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Sun, Lei</creatorcontrib><creatorcontrib>Li, Hengjin</creatorcontrib><creatorcontrib>Lv, Shichao</creatorcontrib><title>Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis</title><title>Cell biochemistry and biophysics</title><addtitle>Cell Biochem Biophys</addtitle><addtitle>Cell Biochem Biophys</addtitle><description>Increased CD143 activity has been detected in various skin tissues, and this increase is partially caused by the intronic ID polymorphism. The genetic contribution of CD143 ID polymorphism to the progression of psoriasis, the commonest skin disease, has been extensively investigated, but reported with inconsistent results. The aim of this work was to gain new insights to shed light on the association between CD143 ID polymorphism and psoriasis risk. We systematically identified the studies examining the association of CD143 ID polymorphism with psoriasis risk. A meta-analysis combining data from all eligible studies was carried out. To evaluate the genetic association, we calculated odds ratio (OR) and its 95 % confidence intervals (CIs) for both genotypic models and allelic model. The final pooling dataset comprised ten studies. Meta-analysis of total samples did not suggest a notable association with psoriasis risk. However, subgroup analysis by ethnicity revealed a statistically significant association in East Asian samples (DD + ID vs. II: OR 0.86, 95 % CI 0.75–0.99, P
heterogeneity
= 0.970; DD vs. ID: OR 0.85, 95 % CI 0.73–0.99, P
heterogeneity
= 0.868; D vs. I: OR 0.86, 95 % CI 0.76–0.97, P
heterogeneity
= 0.994). This meta-analysis demonstrated that the presence of CD143 ID polymorphism may modify the risk of psoriasis in individuals with East Asian ancestry.</description><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Biochemistry</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Biotechnology</subject><subject>Cell Biology</subject><subject>Female</subject><subject>Genetic Association Studies</subject><subject>Genetic Markers - genetics</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Original Paper</subject><subject>Peptidyl-Dipeptidase A - genetics</subject><subject>Pharmacology/Toxicology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Prevalence</subject><subject>Psoriasis</subject><subject>Psoriasis - 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statistics & numerical data</topic><topic>Biochemistry</topic><topic>Biological and Medical Physics</topic><topic>Biomedical and Life Sciences</topic><topic>Biophysics</topic><topic>Biotechnology</topic><topic>Cell Biology</topic><topic>Female</topic><topic>Genetic Association Studies</topic><topic>Genetic Markers - genetics</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Original Paper</topic><topic>Peptidyl-Dipeptidase A - genetics</topic><topic>Pharmacology/Toxicology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Prevalence</topic><topic>Psoriasis</topic><topic>Psoriasis - epidemiology</topic><topic>Psoriasis - genetics</topic><topic>Risk Factors</topic><topic>Skin diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xia, Tianbao</creatorcontrib><creatorcontrib>Diao, Jinfu</creatorcontrib><creatorcontrib>Huang, He</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Sun, Lei</creatorcontrib><creatorcontrib>Li, Hengjin</creatorcontrib><creatorcontrib>Lv, Shichao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>Proquest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cell biochemistry and biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xia, Tianbao</au><au>Diao, Jinfu</au><au>Huang, He</au><au>Li, Jie</au><au>Sun, Lei</au><au>Li, Hengjin</au><au>Lv, Shichao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis</atitle><jtitle>Cell biochemistry and biophysics</jtitle><stitle>Cell Biochem Biophys</stitle><addtitle>Cell Biochem Biophys</addtitle><date>2014-12-01</date><risdate>2014</risdate><volume>70</volume><issue>3</issue><spage>1617</spage><epage>1623</epage><pages>1617-1623</pages><issn>1085-9195</issn><eissn>1559-0283</eissn><abstract>Increased CD143 activity has been detected in various skin tissues, and this increase is partially caused by the intronic ID polymorphism. The genetic contribution of CD143 ID polymorphism to the progression of psoriasis, the commonest skin disease, has been extensively investigated, but reported with inconsistent results. The aim of this work was to gain new insights to shed light on the association between CD143 ID polymorphism and psoriasis risk. We systematically identified the studies examining the association of CD143 ID polymorphism with psoriasis risk. A meta-analysis combining data from all eligible studies was carried out. To evaluate the genetic association, we calculated odds ratio (OR) and its 95 % confidence intervals (CIs) for both genotypic models and allelic model. The final pooling dataset comprised ten studies. Meta-analysis of total samples did not suggest a notable association with psoriasis risk. However, subgroup analysis by ethnicity revealed a statistically significant association in East Asian samples (DD + ID vs. II: OR 0.86, 95 % CI 0.75–0.99, P
heterogeneity
= 0.970; DD vs. ID: OR 0.85, 95 % CI 0.73–0.99, P
heterogeneity
= 0.868; D vs. I: OR 0.86, 95 % CI 0.76–0.97, P
heterogeneity
= 0.994). This meta-analysis demonstrated that the presence of CD143 ID polymorphism may modify the risk of psoriasis in individuals with East Asian ancestry.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24997622</pmid><doi>10.1007/s12013-014-0104-4</doi><tpages>7</tpages></addata></record> |
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| subjects | Asian Continental Ancestry Group - statistics & numerical data Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Biotechnology Cell Biology Female Genetic Association Studies Genetic Markers - genetics Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Heterogeneity Humans Life Sciences Male Original Paper Peptidyl-Dipeptidase A - genetics Pharmacology/Toxicology Polymorphism, Single Nucleotide - genetics Prevalence Psoriasis Psoriasis - epidemiology Psoriasis - genetics Risk Factors Skin diseases |
| title | Evaluation of the Association Between CD143 Gene Polymorphism and Psoriasis |
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