Downregulation of HOXA1 gene affects small cell lung cancer cell survival and chemoresistance under the regulation of miR-100

Abstract Chemoresistance is often developed in small cell lung cancer (SCLC) patients and leads to poor prognosis. Hox genes, a highly conserved family, play a crucial role in apoptosis, receptor signalling and differentiation. MicroRNAs (miRNAs) have also been shown to play a crucial role in these...

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Veröffentlicht in:	European journal of cancer (1990) 2014-05, Vol.50 (8), p.1541-1554
Hauptverfasser:	Xiao, Faman, Bai, Yifeng, Chen, Zhenzhu, Li, Yufa, Luo, Luqiao, Huang, Jie, Yang, Jie, Liao, Hongzhan, Guo, Linlang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Blotting, Western Cell Line, Tumor Down-Regulation - genetics Drug resistance Drug Resistance, Neoplasm - genetics Female Flow Cytometry Hematology, Oncology and Palliative Medicine Homeodomain Proteins - genetics HOXA1 Humans Immunohistochemistry Lung - metabolism Lung - pathology Lung Neoplasms - genetics Lung Neoplasms - mortality Male Medical sciences MicroRNAs - metabolism Middle Aged miRNAs Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments Reverse Transcriptase Polymerase Chain Reaction Small cell lung cancer (SCLC) Small Cell Lung Carcinoma - genetics Small Cell Lung Carcinoma - mortality Survival Survival Analysis Transcription Factors - genetics Transfection Tumors
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