Frequency of Fibroblast Growth Factor Receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome

Summary Objectives Novel therapies are required for patients with recurrent or metastatic oral tongue squamous cell carcinoma (OTSCC). Fibroblast Growth Factor Receptor 1 ( FGFR1 ) amplification frequently occurs in squamous cell carcinoma of the lung and represents a novel druggable therapeutic tar...

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Veröffentlicht in:	Oral oncology 2013-06, Vol.49 (6), p.576-581
Hauptverfasser:	Young, Richard J, Lim, Annette M, Angel, Christopher, Collins, Marnie, Deb, Siddhartha, Corry, June, Wiesenfeld, David, Kleid, Stephen, Sigston, Elizabeth, Lyons, Bernard, Russell, Prudence A, Wright, Gavin, McArthur, Grant A, Fox, Stephen B, Rischin, Danny, Solomon, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - pathology Cohort Studies Female FGFR1 Fibroblast Growth Factor Receptor 1 FISH Fluorescence in situ hybridisation Gene Amplification Hematology, Oncology and Palliative Medicine Humans In Situ Hybridization, Fluorescence Male Medical sciences Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Oral cancer Oral tongue squamous cell carcinoma Otolaryngology Otorhinolaryngology. Stomatology Outcome Receptor, Fibroblast Growth Factor, Type 1 - genetics Tongue Neoplasms - genetics Tongue Neoplasms - pathology Treatment Outcome Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology Young Adult
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