Genomic testing in cancer: Patient knowledge, attitudes, and expectations
BACKGROUND Genomic testing in cancer (GTC) characterizes genes that play an important role in the development and growth of a patient's cancer. This form of DNA testing is currently being studied for its ability to guide cancer therapy. The objective of the current study was to describe patient...
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| Veröffentlicht in: | Cancer 2014-10, Vol.120 (19), p.3066-3073 |
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| container_title | Cancer |
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| creator | Blanchette, Phillip S. Spreafico, Anna Miller, Fiona A. Chan, Kelvin Bytautas, Jessica Kang, Steve Bedard, Philippe L. Eisen, Andrea Potanina, Larissa Holland, Jack Kamel‐Reid, Suzanne McPherson, John D. Razak, Albiruni R. Siu, Lillian L. |
| description | BACKGROUND
Genomic testing in cancer (GTC) characterizes genes that play an important role in the development and growth of a patient's cancer. This form of DNA testing is currently being studied for its ability to guide cancer therapy. The objective of the current study was to describe patients' knowledge, attitudes, and expectations toward GTC.
METHODS
A 42‐item self‐administered GTC questionnaire was developed by a multidisciplinary group and patient pretesting. The questionnaire was distributed to patients with advanced cancer who were referred to the Princess Margaret Cancer Center for a phase 1 clinical trial or GTC testing.
RESULTS
Results were reported from 98 patients with advanced cancer, representing 66% of the patients surveyed. Seventy‐six percent of patients were interested in learning more about GTC, and 64% reported that GTC would significantly improve their cancer care. The median score on a 12‐item questionnaire to assess knowledge of cancer genomics was 8 of 12 items correct (67%; interquartile range, 7‐9 of 12 items correct [58%‐75%]). Scores were associated significantly with patients' education level (P |
| doi_str_mv | 10.1002/cncr.28807 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1639990377</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1564352052</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4647-d0556d84efd8776eccfe316007162ffd7846c662de16cc1472f1797680e104803</originalsourceid><addsrcrecordid>eNqFkEFLwzAUgIMobk4v_gDpUcTOlzRNUm9SdA6Giih4KzV5HdUunU3K3L-3s9Ojnt578PHx-Ag5pjCmAOxCW92MmVIgd8iQQiJDoJztkiEAqDDm0cuAHDj31p2SxdE-GTCeCMaADcl0grZelDrw6Hxp50FpA51bjc1l8JD7Eq0P3m29qtDM8TzIvS99a9B1qzUBfi5R-w6rrTske0VeOTzazhF5vrl-Sm_D2f1kml7NQs0Fl6GBOBZGcSyMklKg1gVGVHSvUcGKwkjFhRaCGaRCa8olK6hMpFCAFLiCaEROe--yqT_a7utsUTqNVZVbrFuXURElSQKRlP-jseBRzCBmHXrWo7qpnWuwyJZNucibdUYh21TONpWz78odfLL1tq8LNL_oT9YOoD2wKitc_6HK0rv0sZd-AdEwhdw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1564352052</pqid></control><display><type>article</type><title>Genomic testing in cancer: Patient knowledge, attitudes, and expectations</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Wiley Free Content</source><source>Alma/SFX Local Collection</source><creator>Blanchette, Phillip S. ; Spreafico, Anna ; Miller, Fiona A. ; Chan, Kelvin ; Bytautas, Jessica ; Kang, Steve ; Bedard, Philippe L. ; Eisen, Andrea ; Potanina, Larissa ; Holland, Jack ; Kamel‐Reid, Suzanne ; McPherson, John D. ; Razak, Albiruni R. ; Siu, Lillian L.</creator><creatorcontrib>Blanchette, Phillip S. ; Spreafico, Anna ; Miller, Fiona A. ; Chan, Kelvin ; Bytautas, Jessica ; Kang, Steve ; Bedard, Philippe L. ; Eisen, Andrea ; Potanina, Larissa ; Holland, Jack ; Kamel‐Reid, Suzanne ; McPherson, John D. ; Razak, Albiruni R. ; Siu, Lillian L.</creatorcontrib><description>BACKGROUND
Genomic testing in cancer (GTC) characterizes genes that play an important role in the development and growth of a patient's cancer. This form of DNA testing is currently being studied for its ability to guide cancer therapy. The objective of the current study was to describe patients' knowledge, attitudes, and expectations toward GTC.
METHODS
A 42‐item self‐administered GTC questionnaire was developed by a multidisciplinary group and patient pretesting. The questionnaire was distributed to patients with advanced cancer who were referred to the Princess Margaret Cancer Center for a phase 1 clinical trial or GTC testing.
RESULTS
Results were reported from 98 patients with advanced cancer, representing 66% of the patients surveyed. Seventy‐six percent of patients were interested in learning more about GTC, and 64% reported that GTC would significantly improve their cancer care. The median score on a 12‐item questionnaire to assess knowledge of cancer genomics was 8 of 12 items correct (67%; interquartile range, 7‐9 of 12 items correct [58%‐75%]). Scores were associated significantly with patients' education level (P < .0001). Sixty‐six percent of patients would consent to a needle biopsy, and 39% would consent to an invasive surgical biopsy if required for GTC. Only 48% of patients reported having sufficient knowledge to make an informed decision to pursue GTC whereas 34% of patients indicated a need for formal genetic counseling.
CONCLUSIONS
Patients with advanced cancer are motivated to participate in GTC. Patients require further education to understand the difference between somatic and germline mutations in the context of GTC. Educational programs are needed to support patients interested in pursuing GTC. Cancer 2014;120:3066–3073. © 2014 American Cancer Society.
Patients with advanced cancer have a positive attitude toward genomic cancer testing and its potential to improve cancer care. Further education is needed to support patients interested in genomic cancer testing.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/cncr.28807</identifier><identifier>PMID: 24962202</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; attitude ; Biopsy - methods ; cancer ; Comprehension ; Decision Making ; Female ; Genetic Counseling ; Genetic Testing ; genomic testing ; Health Knowledge, Attitudes, Practice ; Humans ; Informed Consent ; knowledge ; Male ; Middle Aged ; Neoplasms - genetics ; Ontario ; Patients - statistics & numerical data ; Self Report ; Surveys and Questionnaires</subject><ispartof>Cancer, 2014-10, Vol.120 (19), p.3066-3073</ispartof><rights>2014 American Cancer Society</rights><rights>2014 American Cancer Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4647-d0556d84efd8776eccfe316007162ffd7846c662de16cc1472f1797680e104803</citedby><cites>FETCH-LOGICAL-c4647-d0556d84efd8776eccfe316007162ffd7846c662de16cc1472f1797680e104803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcncr.28807$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcncr.28807$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27903,27904,45553,45554,46388,46812</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24962202$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanchette, Phillip S.</creatorcontrib><creatorcontrib>Spreafico, Anna</creatorcontrib><creatorcontrib>Miller, Fiona A.</creatorcontrib><creatorcontrib>Chan, Kelvin</creatorcontrib><creatorcontrib>Bytautas, Jessica</creatorcontrib><creatorcontrib>Kang, Steve</creatorcontrib><creatorcontrib>Bedard, Philippe L.</creatorcontrib><creatorcontrib>Eisen, Andrea</creatorcontrib><creatorcontrib>Potanina, Larissa</creatorcontrib><creatorcontrib>Holland, Jack</creatorcontrib><creatorcontrib>Kamel‐Reid, Suzanne</creatorcontrib><creatorcontrib>McPherson, John D.</creatorcontrib><creatorcontrib>Razak, Albiruni R.</creatorcontrib><creatorcontrib>Siu, Lillian L.</creatorcontrib><title>Genomic testing in cancer: Patient knowledge, attitudes, and expectations</title><title>Cancer</title><addtitle>Cancer</addtitle><description>BACKGROUND
Genomic testing in cancer (GTC) characterizes genes that play an important role in the development and growth of a patient's cancer. This form of DNA testing is currently being studied for its ability to guide cancer therapy. The objective of the current study was to describe patients' knowledge, attitudes, and expectations toward GTC.
METHODS
A 42‐item self‐administered GTC questionnaire was developed by a multidisciplinary group and patient pretesting. The questionnaire was distributed to patients with advanced cancer who were referred to the Princess Margaret Cancer Center for a phase 1 clinical trial or GTC testing.
RESULTS
Results were reported from 98 patients with advanced cancer, representing 66% of the patients surveyed. Seventy‐six percent of patients were interested in learning more about GTC, and 64% reported that GTC would significantly improve their cancer care. The median score on a 12‐item questionnaire to assess knowledge of cancer genomics was 8 of 12 items correct (67%; interquartile range, 7‐9 of 12 items correct [58%‐75%]). Scores were associated significantly with patients' education level (P < .0001). Sixty‐six percent of patients would consent to a needle biopsy, and 39% would consent to an invasive surgical biopsy if required for GTC. Only 48% of patients reported having sufficient knowledge to make an informed decision to pursue GTC whereas 34% of patients indicated a need for formal genetic counseling.
CONCLUSIONS
Patients with advanced cancer are motivated to participate in GTC. Patients require further education to understand the difference between somatic and germline mutations in the context of GTC. Educational programs are needed to support patients interested in pursuing GTC. Cancer 2014;120:3066–3073. © 2014 American Cancer Society.
Patients with advanced cancer have a positive attitude toward genomic cancer testing and its potential to improve cancer care. Further education is needed to support patients interested in genomic cancer testing.</description><subject>Adult</subject><subject>Aged</subject><subject>attitude</subject><subject>Biopsy - methods</subject><subject>cancer</subject><subject>Comprehension</subject><subject>Decision Making</subject><subject>Female</subject><subject>Genetic Counseling</subject><subject>Genetic Testing</subject><subject>genomic testing</subject><subject>Health Knowledge, Attitudes, Practice</subject><subject>Humans</subject><subject>Informed Consent</subject><subject>knowledge</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - genetics</subject><subject>Ontario</subject><subject>Patients - statistics & numerical data</subject><subject>Self Report</subject><subject>Surveys and Questionnaires</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLwzAUgIMobk4v_gDpUcTOlzRNUm9SdA6Giih4KzV5HdUunU3K3L-3s9Ojnt578PHx-Ag5pjCmAOxCW92MmVIgd8iQQiJDoJztkiEAqDDm0cuAHDj31p2SxdE-GTCeCMaADcl0grZelDrw6Hxp50FpA51bjc1l8JD7Eq0P3m29qtDM8TzIvS99a9B1qzUBfi5R-w6rrTske0VeOTzazhF5vrl-Sm_D2f1kml7NQs0Fl6GBOBZGcSyMklKg1gVGVHSvUcGKwkjFhRaCGaRCa8olK6hMpFCAFLiCaEROe--yqT_a7utsUTqNVZVbrFuXURElSQKRlP-jseBRzCBmHXrWo7qpnWuwyJZNucibdUYh21TONpWz78odfLL1tq8LNL_oT9YOoD2wKitc_6HK0rv0sZd-AdEwhdw</recordid><startdate>20141001</startdate><enddate>20141001</enddate><creator>Blanchette, Phillip S.</creator><creator>Spreafico, Anna</creator><creator>Miller, Fiona A.</creator><creator>Chan, Kelvin</creator><creator>Bytautas, Jessica</creator><creator>Kang, Steve</creator><creator>Bedard, Philippe L.</creator><creator>Eisen, Andrea</creator><creator>Potanina, Larissa</creator><creator>Holland, Jack</creator><creator>Kamel‐Reid, Suzanne</creator><creator>McPherson, John D.</creator><creator>Razak, Albiruni R.</creator><creator>Siu, Lillian L.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20141001</creationdate><title>Genomic testing in cancer: Patient knowledge, attitudes, and expectations</title><author>Blanchette, Phillip S. ; Spreafico, Anna ; Miller, Fiona A. ; Chan, Kelvin ; Bytautas, Jessica ; Kang, Steve ; Bedard, Philippe L. ; Eisen, Andrea ; Potanina, Larissa ; Holland, Jack ; Kamel‐Reid, Suzanne ; McPherson, John D. ; Razak, Albiruni R. ; Siu, Lillian L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4647-d0556d84efd8776eccfe316007162ffd7846c662de16cc1472f1797680e104803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>attitude</topic><topic>Biopsy - methods</topic><topic>cancer</topic><topic>Comprehension</topic><topic>Decision Making</topic><topic>Female</topic><topic>Genetic Counseling</topic><topic>Genetic Testing</topic><topic>genomic testing</topic><topic>Health Knowledge, Attitudes, Practice</topic><topic>Humans</topic><topic>Informed Consent</topic><topic>knowledge</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms - genetics</topic><topic>Ontario</topic><topic>Patients - statistics & numerical data</topic><topic>Self Report</topic><topic>Surveys and Questionnaires</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanchette, Phillip S.</creatorcontrib><creatorcontrib>Spreafico, Anna</creatorcontrib><creatorcontrib>Miller, Fiona A.</creatorcontrib><creatorcontrib>Chan, Kelvin</creatorcontrib><creatorcontrib>Bytautas, Jessica</creatorcontrib><creatorcontrib>Kang, Steve</creatorcontrib><creatorcontrib>Bedard, Philippe L.</creatorcontrib><creatorcontrib>Eisen, Andrea</creatorcontrib><creatorcontrib>Potanina, Larissa</creatorcontrib><creatorcontrib>Holland, Jack</creatorcontrib><creatorcontrib>Kamel‐Reid, Suzanne</creatorcontrib><creatorcontrib>McPherson, John D.</creatorcontrib><creatorcontrib>Razak, Albiruni R.</creatorcontrib><creatorcontrib>Siu, Lillian L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanchette, Phillip S.</au><au>Spreafico, Anna</au><au>Miller, Fiona A.</au><au>Chan, Kelvin</au><au>Bytautas, Jessica</au><au>Kang, Steve</au><au>Bedard, Philippe L.</au><au>Eisen, Andrea</au><au>Potanina, Larissa</au><au>Holland, Jack</au><au>Kamel‐Reid, Suzanne</au><au>McPherson, John D.</au><au>Razak, Albiruni R.</au><au>Siu, Lillian L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genomic testing in cancer: Patient knowledge, attitudes, and expectations</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>2014-10-01</date><risdate>2014</risdate><volume>120</volume><issue>19</issue><spage>3066</spage><epage>3073</epage><pages>3066-3073</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>BACKGROUND
Genomic testing in cancer (GTC) characterizes genes that play an important role in the development and growth of a patient's cancer. This form of DNA testing is currently being studied for its ability to guide cancer therapy. The objective of the current study was to describe patients' knowledge, attitudes, and expectations toward GTC.
METHODS
A 42‐item self‐administered GTC questionnaire was developed by a multidisciplinary group and patient pretesting. The questionnaire was distributed to patients with advanced cancer who were referred to the Princess Margaret Cancer Center for a phase 1 clinical trial or GTC testing.
RESULTS
Results were reported from 98 patients with advanced cancer, representing 66% of the patients surveyed. Seventy‐six percent of patients were interested in learning more about GTC, and 64% reported that GTC would significantly improve their cancer care. The median score on a 12‐item questionnaire to assess knowledge of cancer genomics was 8 of 12 items correct (67%; interquartile range, 7‐9 of 12 items correct [58%‐75%]). Scores were associated significantly with patients' education level (P < .0001). Sixty‐six percent of patients would consent to a needle biopsy, and 39% would consent to an invasive surgical biopsy if required for GTC. Only 48% of patients reported having sufficient knowledge to make an informed decision to pursue GTC whereas 34% of patients indicated a need for formal genetic counseling.
CONCLUSIONS
Patients with advanced cancer are motivated to participate in GTC. Patients require further education to understand the difference between somatic and germline mutations in the context of GTC. Educational programs are needed to support patients interested in pursuing GTC. Cancer 2014;120:3066–3073. © 2014 American Cancer Society.
Patients with advanced cancer have a positive attitude toward genomic cancer testing and its potential to improve cancer care. Further education is needed to support patients interested in genomic cancer testing.</abstract><cop>United States</cop><pmid>24962202</pmid><doi>10.1002/cncr.28807</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wiley Free Content; Alma/SFX Local Collection |
| subjects | Adult Aged attitude Biopsy - methods cancer Comprehension Decision Making Female Genetic Counseling Genetic Testing genomic testing Health Knowledge, Attitudes, Practice Humans Informed Consent knowledge Male Middle Aged Neoplasms - genetics Ontario Patients - statistics & numerical data Self Report Surveys and Questionnaires |
| title | Genomic testing in cancer: Patient knowledge, attitudes, and expectations |
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