Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis
Cancer cells have countless behaviors of pluripotent embryonic stem cells and germ line cells, such as unlimited proliferation, self-renewal, and migration. Expression of specific germ line and embryonic genes in tumor cells may be associated with indefinite growth and invasiveness of such cells. De...
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| Veröffentlicht in: | Tumor biology 2014-06, Vol.35 (6), p.5299-5305 |
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| creator | Raeisossadati, Reza Abbaszadegan, Mohammad Reza Moghbeli, Meysam Tavassoli, Alireza Kihara, Alexandre Hiroaki Forghanifard, Mohammad Mahdi |
| description | Cancer cells have countless behaviors of pluripotent embryonic stem cells and germ line cells, such as unlimited proliferation, self-renewal, and migration. Expression of specific germ line and embryonic genes in tumor cells may be associated with indefinite growth and invasiveness of such cells. Developmental pluripotency factor 2 (DPPA2) and HIWI are two important developmental genes which are involved in embryonic and germ line stem cell properties. Deciphering the role of these genes seems to be necessary for understanding cancer initiation and progression. Tumoral and normal tissues from 46 colorectal cancer (CRC) patients were subjected to gene expression analysis using quantitative real-time reverse transcription-polymerase chain reaction, prior to any therapeutic intervention. Overexpression of DPPA2 and HIWI was detected in 26.1 and 34.8 % of specimens, respectively. Significant correlation between DPPA2 overexpression and lymph node metastasis of the tumor cells (
P
= 0.049) was seen in the samples with advanced stages (III/IV) of the tumor development. HIWI mRNA expression was significantly associated to the depth of tumor invasion (
P
= 0.020) and the stage of tumorigenesis progression (
P
= 0.030). In samples with overexpression of at least one gene, DPPA2 mRNA expression was significantly correlated to the stage of tumor (
P
= 0.017). In the same samples, a significant correlation was observed between mRNA expression of HIWI and the stage of tumor cells (
P
= 0.034). These results documented the important role of HIWI and DPPA2 in tumorigenesis and also in lymph node metastasis of tumor cells. Further evaluation is required to uncover the detailed role of HIWI and DPPA2 and their interactions in tumorigenesis of CRC. |
| doi_str_mv | 10.1007/s13277-014-1690-x |
| format | Article |
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P
= 0.049) was seen in the samples with advanced stages (III/IV) of the tumor development. HIWI mRNA expression was significantly associated to the depth of tumor invasion (
P
= 0.020) and the stage of tumorigenesis progression (
P
= 0.030). In samples with overexpression of at least one gene, DPPA2 mRNA expression was significantly correlated to the stage of tumor (
P
= 0.017). In the same samples, a significant correlation was observed between mRNA expression of HIWI and the stage of tumor cells (
P
= 0.034). These results documented the important role of HIWI and DPPA2 in tumorigenesis and also in lymph node metastasis of tumor cells. Further evaluation is required to uncover the detailed role of HIWI and DPPA2 and their interactions in tumorigenesis of CRC.</description><identifier>ISSN: 1010-4283</identifier><identifier>EISSN: 1423-0380</identifier><identifier>DOI: 10.1007/s13277-014-1690-x</identifier><identifier>PMID: 24532429</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Argonaute Proteins - genetics ; Argonaute Proteins - physiology ; Biomedical and Life Sciences ; Biomedicine ; Cancer Research ; Colorectal cancer ; Colorectal Neoplasms - blood supply ; Colorectal Neoplasms - etiology ; Colorectal Neoplasms - pathology ; Female ; Gene expression ; Humans ; Lymphatic Metastasis ; Male ; Medical prognosis ; Metastasis ; Neoplasm Staging ; Nuclear Proteins - genetics ; Nuclear Proteins - physiology ; Polymerase chain reaction ; Prognosis ; Research Article ; RNA, Messenger - analysis ; Tumorigenesis</subject><ispartof>Tumor biology, 2014-06, Vol.35 (6), p.5299-5305</ispartof><rights>International Society of Oncology and BioMarkers (ISOBM) 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-6c8dd23f085a311536d1c50eaa6f1386fc0dfc27b4e0385140eb4f803cf5da3b3</citedby><cites>FETCH-LOGICAL-c475t-6c8dd23f085a311536d1c50eaa6f1386fc0dfc27b4e0385140eb4f803cf5da3b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s13277-014-1690-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s13277-014-1690-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24532429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Raeisossadati, Reza</creatorcontrib><creatorcontrib>Abbaszadegan, Mohammad Reza</creatorcontrib><creatorcontrib>Moghbeli, Meysam</creatorcontrib><creatorcontrib>Tavassoli, Alireza</creatorcontrib><creatorcontrib>Kihara, Alexandre Hiroaki</creatorcontrib><creatorcontrib>Forghanifard, Mohammad Mahdi</creatorcontrib><title>Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis</title><title>Tumor biology</title><addtitle>Tumor Biol</addtitle><addtitle>Tumour Biol</addtitle><description>Cancer cells have countless behaviors of pluripotent embryonic stem cells and germ line cells, such as unlimited proliferation, self-renewal, and migration. Expression of specific germ line and embryonic genes in tumor cells may be associated with indefinite growth and invasiveness of such cells. Developmental pluripotency factor 2 (DPPA2) and HIWI are two important developmental genes which are involved in embryonic and germ line stem cell properties. Deciphering the role of these genes seems to be necessary for understanding cancer initiation and progression. Tumoral and normal tissues from 46 colorectal cancer (CRC) patients were subjected to gene expression analysis using quantitative real-time reverse transcription-polymerase chain reaction, prior to any therapeutic intervention. Overexpression of DPPA2 and HIWI was detected in 26.1 and 34.8 % of specimens, respectively. Significant correlation between DPPA2 overexpression and lymph node metastasis of the tumor cells (
P
= 0.049) was seen in the samples with advanced stages (III/IV) of the tumor development. HIWI mRNA expression was significantly associated to the depth of tumor invasion (
P
= 0.020) and the stage of tumorigenesis progression (
P
= 0.030). In samples with overexpression of at least one gene, DPPA2 mRNA expression was significantly correlated to the stage of tumor (
P
= 0.017). In the same samples, a significant correlation was observed between mRNA expression of HIWI and the stage of tumor cells (
P
= 0.034). These results documented the important role of HIWI and DPPA2 in tumorigenesis and also in lymph node metastasis of tumor cells. Further evaluation is required to uncover the detailed role of HIWI and DPPA2 and their interactions in tumorigenesis of CRC.</description><subject>Argonaute Proteins - genetics</subject><subject>Argonaute Proteins - physiology</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cancer Research</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - blood supply</subject><subject>Colorectal Neoplasms - etiology</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Female</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Neoplasm Staging</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - physiology</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Research Article</subject><subject>RNA, Messenger - 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Academic</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Tumor biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Raeisossadati, Reza</au><au>Abbaszadegan, Mohammad Reza</au><au>Moghbeli, Meysam</au><au>Tavassoli, Alireza</au><au>Kihara, Alexandre Hiroaki</au><au>Forghanifard, Mohammad Mahdi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis</atitle><jtitle>Tumor biology</jtitle><stitle>Tumor Biol</stitle><addtitle>Tumour Biol</addtitle><date>2014-06-01</date><risdate>2014</risdate><volume>35</volume><issue>6</issue><spage>5299</spage><epage>5305</epage><pages>5299-5305</pages><issn>1010-4283</issn><eissn>1423-0380</eissn><abstract>Cancer cells have countless behaviors of pluripotent embryonic stem cells and germ line cells, such as unlimited proliferation, self-renewal, and migration. Expression of specific germ line and embryonic genes in tumor cells may be associated with indefinite growth and invasiveness of such cells. Developmental pluripotency factor 2 (DPPA2) and HIWI are two important developmental genes which are involved in embryonic and germ line stem cell properties. Deciphering the role of these genes seems to be necessary for understanding cancer initiation and progression. Tumoral and normal tissues from 46 colorectal cancer (CRC) patients were subjected to gene expression analysis using quantitative real-time reverse transcription-polymerase chain reaction, prior to any therapeutic intervention. Overexpression of DPPA2 and HIWI was detected in 26.1 and 34.8 % of specimens, respectively. Significant correlation between DPPA2 overexpression and lymph node metastasis of the tumor cells (
P
= 0.049) was seen in the samples with advanced stages (III/IV) of the tumor development. HIWI mRNA expression was significantly associated to the depth of tumor invasion (
P
= 0.020) and the stage of tumorigenesis progression (
P
= 0.030). In samples with overexpression of at least one gene, DPPA2 mRNA expression was significantly correlated to the stage of tumor (
P
= 0.017). In the same samples, a significant correlation was observed between mRNA expression of HIWI and the stage of tumor cells (
P
= 0.034). These results documented the important role of HIWI and DPPA2 in tumorigenesis and also in lymph node metastasis of tumor cells. Further evaluation is required to uncover the detailed role of HIWI and DPPA2 and their interactions in tumorigenesis of CRC.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>24532429</pmid><doi>10.1007/s13277-014-1690-x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Argonaute Proteins - genetics Argonaute Proteins - physiology Biomedical and Life Sciences Biomedicine Cancer Research Colorectal cancer Colorectal Neoplasms - blood supply Colorectal Neoplasms - etiology Colorectal Neoplasms - pathology Female Gene expression Humans Lymphatic Metastasis Male Medical prognosis Metastasis Neoplasm Staging Nuclear Proteins - genetics Nuclear Proteins - physiology Polymerase chain reaction Prognosis Research Article RNA, Messenger - analysis Tumorigenesis |
| title | Aberrant expression of DPPA2 and HIWI genes in colorectal cancer and their impacts on poor prognosis |
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