Dopamine favors expansion of glucocorticoid-resistant IL-17-producing T cells in multiple sclerosis

Abstract Dopamine (DA) is a neurotransmitter produced mainly in the central nervous system (CNS) that has immunomodulatory actions on T cells. As the multiple sclerosis (MS) has long been regarded as an autoimmune disease of CNS mediated by T cells, the objective of this study was to evaluate the im...

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Veröffentlicht in:	Brain, behavior, and immunity behavior, and immunity, 2014-10, Vol.41, p.182-190
Hauptverfasser:	Ferreira, Thais B, Barros, Priscila O, Teixeira, Bruna, Cassano, Tatiane, Centurião, Newton, Kasahara, Taissa M, Hygino, Joana, Vasconcelos, Claudia Cristina F, Filho, Helcio Alvarenga, Alvarenga, Regina, Wing, Ana Cristina, Andrade, Regis M, Andrade, Arnaldo F, Bento, Cleonice A.M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergy and Immunology CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism Cell Division Cells, Cultured Cytokines Dopamine Dopamine - pharmacology Drug Resistance Female Humans IL-10 Interleukin-10 - biosynthesis Interleukin-10 - genetics Interleukin-6 - biosynthesis Interleukin-6 - genetics Lipopolysaccharide Lymphocyte Activation Male Middle Aged Monocytes - drug effects Monocytes - metabolism Multiple sclerosis Multiple Sclerosis, Relapsing-Remitting - immunology Multiple Sclerosis, Relapsing-Remitting - metabolism Neuroimmunomodulation - physiology Phytohemagglutinins - pharmacology Psychiatry Severity of Illness Index T cells Th17 Th17 Cells - immunology Transforming Growth Factor beta - biosynthesis Transforming Growth Factor beta - genetics Young Adult
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