VP2, VP7, and NS1 proteins of bluetongue virus targeted in avian reovirus muNS-Mi microspheres elicit a protective immune response in IFNAR(-/-) mice

Vaccination is critical for controlling the spread of bluetongue virus (BTV). The inactivated BTV vaccines that are now being used in Europe are effective in preventing outbreaks of BTV but secondary effects associated to repetitive inoculation of aluminum-containing adjuvants and the need to develo...

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Veröffentlicht in:	Antiviral research 2014-10, Vol.110, p.42-51
Hauptverfasser:	MARIN-LOPEZ, Alejandro, OTERO-ROMERO, Iria, DE LA POZA, Francisco, MENAYA-VARGAS, Rebeca, CALVO-PINILLA, Eva, BENAVENTE, Javier, MARTINEZ-COSTAS, José M, ORTEGO, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antiviral agents Avian reovirus Baculoviridae - genetics Biological and medical sciences Bluetongue - immunology Bluetongue - prevention & control Bluetongue virus Bluetongue virus - immunology Capsid Proteins - genetics Capsid Proteins - immunology CD4-Positive T-Lymphocytes - immunology Cell Line Cercopithecus aethiops Chick Embryo Cricetinae Drug Carriers - therapeutic use Male Medical sciences Mice Mice, Knockout Microspheres Orthoreovirus, Avian - genetics Orthoreovirus, Avian - immunology Pharmacology. Drug treatments Sf9 Cells Sheep - virology Spodoptera Vaccination Vaccines, Subunit - immunology Vero Cells Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Viral Vaccines - immunology
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