Epithelial-mesenchymal transition-associated microRNAs in colorectal cancer and drug-targeted therapies (Review)
Colorectal cancer (CRC) is one of the most common malignancies, and the third leading cause of cancer-associated mortality worldwide. Therefore, the identification of effective targets at the early stages of cancer invasion and metastasis, and new tumor markers for early diagnosis and individualized...
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| Veröffentlicht in: | Oncology reports 2015-02, Vol.33 (2), p.515-525 |
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| creator | JIN, DANJUAN FANG, YANTIAN LI, ZHENGYANG CHEN, ZONGYOU XIANG, JIANBIN |
| description | Colorectal cancer (CRC) is one of the most common malignancies, and the third leading cause of cancer-associated mortality worldwide. Therefore, the identification of effective targets at the early stages of cancer invasion and metastasis, and new tumor markers for early diagnosis and individualized treatment is imperative for CRC. Epithelial-mesenchymal transition (EMT) refers to the phenomenon of the transformation of epithelial cells to mesenchymal cells in specific physiological and/or pathological circumstances. Evidence suggests that EMT plays an important role in in situ infiltration and distant metastasis of many types of cancer, including CRC. Recent findings showed that microRNA expression is important in regulating the EMT process. This review aimed to summarize EMT-associated specific miRNA molecules in CRC, with particular emphasis on clinical targets for effective treatment of this lethal disease. |
| doi_str_mv | 10.3892/or.2014.3638 |
| format | Article |
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Spandidos</publisher><subject>Animals ; Antineoplastic Agents - therapeutic use ; Cancer therapies ; Cell adhesion & migration ; Cell development (Biology) ; Cell growth ; Colorectal cancer ; Colorectal Neoplasms - drug therapy ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; Drug targeting ; Drug therapy ; Epithelial cells ; epithelial-mesenchymal transition ; Epithelial-Mesenchymal Transition - drug effects ; Extracellular matrix ; Fibroblasts ; Gene therapy ; Genetic aspects ; Glycoproteins ; Health aspects ; Humans ; Lung cancer ; Metastasis ; Methods ; MicroRNA ; MicroRNAs ; MicroRNAs - antagonists & inhibitors ; MicroRNAs - genetics ; Molecular Targeted Therapy - methods ; Morphology ; Prostate ; Proteins ; Rodents ; Studies ; Transcription factors ; Tumors</subject><ispartof>Oncology reports, 2015-02, Vol.33 (2), p.515-525</ispartof><rights>Copyright © 2015, Spandidos Publications</rights><rights>COPYRIGHT 2015 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486t-34fd439cce3e2c498914767432e543735dd411654d17d003e153835c61f43c5e3</citedby><cites>FETCH-LOGICAL-c486t-34fd439cce3e2c498914767432e543735dd411654d17d003e153835c61f43c5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25435189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>JIN, DANJUAN</creatorcontrib><creatorcontrib>FANG, YANTIAN</creatorcontrib><creatorcontrib>LI, ZHENGYANG</creatorcontrib><creatorcontrib>CHEN, ZONGYOU</creatorcontrib><creatorcontrib>XIANG, JIANBIN</creatorcontrib><title>Epithelial-mesenchymal transition-associated microRNAs in colorectal cancer and drug-targeted therapies (Review)</title><title>Oncology reports</title><addtitle>Oncol Rep</addtitle><description>Colorectal cancer (CRC) is one of the most common malignancies, and the third leading cause of cancer-associated mortality worldwide. 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| subjects | Animals Antineoplastic Agents - therapeutic use Cancer therapies Cell adhesion & migration Cell development (Biology) Cell growth Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Drug targeting Drug therapy Epithelial cells epithelial-mesenchymal transition Epithelial-Mesenchymal Transition - drug effects Extracellular matrix Fibroblasts Gene therapy Genetic aspects Glycoproteins Health aspects Humans Lung cancer Metastasis Methods MicroRNA MicroRNAs MicroRNAs - antagonists & inhibitors MicroRNAs - genetics Molecular Targeted Therapy - methods Morphology Prostate Proteins Rodents Studies Transcription factors Tumors |
| title | Epithelial-mesenchymal transition-associated microRNAs in colorectal cancer and drug-targeted therapies (Review) |
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