Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation

Background & Aims Interferon alfa–based regimens used to treat recurrent hepatitis C virus (HCV) infection after liver transplantation are poorly tolerated, associated with generally modest efficacy, and can interact with immunosuppressive agents. We evaluated the efficacy and safety of an inter...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2015, Vol.148 (1), p.108-117
Hauptverfasser:	Charlton, Michael, Gane, Edward, Manns, Michael P, Brown, Robert S, Curry, Michael P, Kwo, Paul Y, Fontana, Robert J, Gilroy, Richard, Teperman, Lewis, Muir, Andrew J, McHutchison, John G, Symonds, William T, Brainard, Diana, Kirby, Brian, Dvory-Sobol, Hadas, Denning, Jill, Arterburn, Sarah, Samuel, Didier, Forns, Xavier, Terrault, Norah A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agent Antiviral Agents - adverse effects Antiviral Agents - pharmacokinetics Antiviral Agents - therapeutic use Biomarkers - blood Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - surgery Carcinoma, Hepatocellular - virology Clinical Trial DAA Drug Resistance, Viral Drug Therapy, Combination Female Gastroenterology and Hepatology Genotype Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - pathogenicity Hepatitis C - complications Hepatitis C - diagnosis Hepatitis C - drug therapy Humans Liver Cirrhosis - diagnosis Liver Cirrhosis - surgery Liver Cirrhosis - virology Liver Neoplasms - diagnosis Liver Neoplasms - surgery Liver Neoplasms - virology Liver Transplantation - adverse effects Male New Zealand NS5B Polymerase Inhibitor Pilot Projects Prospective Studies Recurrence Ribavirin - adverse effects Ribavirin - pharmacokinetics Ribavirin - therapeutic use RNA, Viral - blood Sofosbuvir Spain Time Factors Treatment Outcome United States Uridine Monophosphate - adverse effects Uridine Monophosphate - analogs & derivatives Uridine Monophosphate - pharmacokinetics Uridine Monophosphate - therapeutic use Viral Load
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