Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer
Background Both androgenetic alopecia (AGA) and carcinoma of the prostate (CaP) or benign prostatic hyperplasia (BPH) are androgen‐dependent disorders. Objective To investigate the relationships between male androgenetic alopecia, androgen receptor (AR) gene polymorphism (SNP rs6152) and clinical ch...
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| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2015-01, Vol.29 (1), p.91-96 |
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| container_title | Journal of the European Academy of Dermatology and Venereology |
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| creator | Kucerova, R. Bienova, M. Kral, M. Bouchal, J. Trtkova, K.S. Burdova, A. Student, V. Kolar, Z. |
| description | Background
Both androgenetic alopecia (AGA) and carcinoma of the prostate (CaP) or benign prostatic hyperplasia (BPH) are androgen‐dependent disorders.
Objective
To investigate the relationships between male androgenetic alopecia, androgen receptor (AR) gene polymorphism (SNP rs6152) and clinical characteristics of BPH and prostate cancer.
Methods
Overall, 309 male subjects with prostate disease (BPH or CaP) were examined. We evaluated the standard grades of AGA (I–VII) by Hamilton–Norwood classification and 195 patients were also assessed by phototrichogram. Prostate‐specific antigen (PSA) and testosterone levels were also measured. Polymorphism rs6152 of the AR was evaluated from blood samples by PCR‐RFLP. Data were statistically evaluated.
Results
The expected positive correlation between age and AGA grade and the expected negative correlation between hair density and age and between anagen/telogen and AGA were found. A statistically significant difference between patients with A and G alleles in terms of AGA grade was found. The predominant G allele was more frequent in patients with higher grade of alopecia and in patients with significantly higher PSA. There was no correlation between diagnosis (BPH or CaP) and polymorphism. Patients with prostate inflammation had a statistically significant higher grade of AGA, together with higher PSA.
Conclusions
We confirmed that the AR gene polymorphism (SNP rs6152 G>A) is associated with the development of AGA and higher PSA levels in patients with BPH but not cancer. A novel finding of our study is that BPH patients with prostate inflammation had a significantly higher grade of AGA together with significantly higher PSA levels. |
| doi_str_mv | 10.1111/jdv.12468 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1639981820</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1639981820</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4338-d7a11ed0d8fcd236f6938115c165a1824ef76f539f7ea36c3326dd5813037d183</originalsourceid><addsrcrecordid>eNp1kUtPGzEUhS3UClLKgj9QeQmLAXtuxmMveTW0QrRSH0hsLGPfIabzwnZK8zP6j-sQyK7eXOnoO-faPoTsc3bE8zl-cL-PeDkVcotMeB4FMAlvyISpUhRKVWqHvIvxgTHGeSW3yU5mRaVKNSF_T3oXhnvsMXlLTTuMaL2hpnd0HNplN4Rx7mNHh4amOa70Z5oGtDimIdCVlR58u_5KQxS8Kg-p7-loksc-Rfrk05zeYe_vsxiGmExCOl-OGMbWxLwoJ2x0a3qL4T1525g24t7L3CU_Pl58P7ssrr7MPp2dXBV2CiALVxvO0TEnG-tKEI1QIPPzLBeV4bKcYlOLpgLV1GhAWIBSOFdJDgxqxyXskoN1bt7_uMCYdOejxbY1PQ6LqLkApWROYhk9XKM2XzUGbPQYfGfCUnOmVw3o3IB-biCzH15iF3cdug35-uUZOF4DT77F5f-T9Ofzn6-RxdrhY8I_G4cJv7Sooa70zfVMn_PTy9ntDPQp_AMrUKBU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1639981820</pqid></control><display><type>article</type><title>Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kucerova, R. ; Bienova, M. ; Kral, M. ; Bouchal, J. ; Trtkova, K.S. ; Burdova, A. ; Student, V. ; Kolar, Z.</creator><creatorcontrib>Kucerova, R. ; Bienova, M. ; Kral, M. ; Bouchal, J. ; Trtkova, K.S. ; Burdova, A. ; Student, V. ; Kolar, Z.</creatorcontrib><description>Background
Both androgenetic alopecia (AGA) and carcinoma of the prostate (CaP) or benign prostatic hyperplasia (BPH) are androgen‐dependent disorders.
Objective
To investigate the relationships between male androgenetic alopecia, androgen receptor (AR) gene polymorphism (SNP rs6152) and clinical characteristics of BPH and prostate cancer.
Methods
Overall, 309 male subjects with prostate disease (BPH or CaP) were examined. We evaluated the standard grades of AGA (I–VII) by Hamilton–Norwood classification and 195 patients were also assessed by phototrichogram. Prostate‐specific antigen (PSA) and testosterone levels were also measured. Polymorphism rs6152 of the AR was evaluated from blood samples by PCR‐RFLP. Data were statistically evaluated.
Results
The expected positive correlation between age and AGA grade and the expected negative correlation between hair density and age and between anagen/telogen and AGA were found. A statistically significant difference between patients with A and G alleles in terms of AGA grade was found. The predominant G allele was more frequent in patients with higher grade of alopecia and in patients with significantly higher PSA. There was no correlation between diagnosis (BPH or CaP) and polymorphism. Patients with prostate inflammation had a statistically significant higher grade of AGA, together with higher PSA.
Conclusions
We confirmed that the AR gene polymorphism (SNP rs6152 G>A) is associated with the development of AGA and higher PSA levels in patients with BPH but not cancer. A novel finding of our study is that BPH patients with prostate inflammation had a significantly higher grade of AGA together with significantly higher PSA levels.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/jdv.12468</identifier><identifier>PMID: 24665929</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Alleles ; Alopecia - blood ; Alopecia - complications ; Alopecia - genetics ; Carcinoma - blood ; Carcinoma - complications ; Carcinoma - genetics ; Humans ; Male ; Middle Aged ; Polymorphism, Single Nucleotide ; Prostate-Specific Antigen - blood ; Prostatic Hyperplasia - blood ; Prostatic Hyperplasia - complications ; Prostatic Hyperplasia - genetics ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - complications ; Prostatic Neoplasms - genetics ; Receptors, Androgen - genetics ; Severity of Illness Index ; Testosterone - blood</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2015-01, Vol.29 (1), p.91-96</ispartof><rights>2014 European Academy of Dermatology and Venereology</rights><rights>2014 European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4338-d7a11ed0d8fcd236f6938115c165a1824ef76f539f7ea36c3326dd5813037d183</citedby><cites>FETCH-LOGICAL-c4338-d7a11ed0d8fcd236f6938115c165a1824ef76f539f7ea36c3326dd5813037d183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjdv.12468$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjdv.12468$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24665929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kucerova, R.</creatorcontrib><creatorcontrib>Bienova, M.</creatorcontrib><creatorcontrib>Kral, M.</creatorcontrib><creatorcontrib>Bouchal, J.</creatorcontrib><creatorcontrib>Trtkova, K.S.</creatorcontrib><creatorcontrib>Burdova, A.</creatorcontrib><creatorcontrib>Student, V.</creatorcontrib><creatorcontrib>Kolar, Z.</creatorcontrib><title>Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background
Both androgenetic alopecia (AGA) and carcinoma of the prostate (CaP) or benign prostatic hyperplasia (BPH) are androgen‐dependent disorders.
Objective
To investigate the relationships between male androgenetic alopecia, androgen receptor (AR) gene polymorphism (SNP rs6152) and clinical characteristics of BPH and prostate cancer.
Methods
Overall, 309 male subjects with prostate disease (BPH or CaP) were examined. We evaluated the standard grades of AGA (I–VII) by Hamilton–Norwood classification and 195 patients were also assessed by phototrichogram. Prostate‐specific antigen (PSA) and testosterone levels were also measured. Polymorphism rs6152 of the AR was evaluated from blood samples by PCR‐RFLP. Data were statistically evaluated.
Results
The expected positive correlation between age and AGA grade and the expected negative correlation between hair density and age and between anagen/telogen and AGA were found. A statistically significant difference between patients with A and G alleles in terms of AGA grade was found. The predominant G allele was more frequent in patients with higher grade of alopecia and in patients with significantly higher PSA. There was no correlation between diagnosis (BPH or CaP) and polymorphism. Patients with prostate inflammation had a statistically significant higher grade of AGA, together with higher PSA.
Conclusions
We confirmed that the AR gene polymorphism (SNP rs6152 G>A) is associated with the development of AGA and higher PSA levels in patients with BPH but not cancer. A novel finding of our study is that BPH patients with prostate inflammation had a significantly higher grade of AGA together with significantly higher PSA levels.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alleles</subject><subject>Alopecia - blood</subject><subject>Alopecia - complications</subject><subject>Alopecia - genetics</subject><subject>Carcinoma - blood</subject><subject>Carcinoma - complications</subject><subject>Carcinoma - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prostate-Specific Antigen - blood</subject><subject>Prostatic Hyperplasia - blood</subject><subject>Prostatic Hyperplasia - complications</subject><subject>Prostatic Hyperplasia - genetics</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - complications</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Receptors, Androgen - genetics</subject><subject>Severity of Illness Index</subject><subject>Testosterone - blood</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtPGzEUhS3UClLKgj9QeQmLAXtuxmMveTW0QrRSH0hsLGPfIabzwnZK8zP6j-sQyK7eXOnoO-faPoTsc3bE8zl-cL-PeDkVcotMeB4FMAlvyISpUhRKVWqHvIvxgTHGeSW3yU5mRaVKNSF_T3oXhnvsMXlLTTuMaL2hpnd0HNplN4Rx7mNHh4amOa70Z5oGtDimIdCVlR58u_5KQxS8Kg-p7-loksc-Rfrk05zeYe_vsxiGmExCOl-OGMbWxLwoJ2x0a3qL4T1525g24t7L3CU_Pl58P7ssrr7MPp2dXBV2CiALVxvO0TEnG-tKEI1QIPPzLBeV4bKcYlOLpgLV1GhAWIBSOFdJDgxqxyXskoN1bt7_uMCYdOejxbY1PQ6LqLkApWROYhk9XKM2XzUGbPQYfGfCUnOmVw3o3IB-biCzH15iF3cdug35-uUZOF4DT77F5f-T9Ofzn6-RxdrhY8I_G4cJv7Sooa70zfVMn_PTy9ntDPQp_AMrUKBU</recordid><startdate>201501</startdate><enddate>201501</enddate><creator>Kucerova, R.</creator><creator>Bienova, M.</creator><creator>Kral, M.</creator><creator>Bouchal, J.</creator><creator>Trtkova, K.S.</creator><creator>Burdova, A.</creator><creator>Student, V.</creator><creator>Kolar, Z.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201501</creationdate><title>Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer</title><author>Kucerova, R. ; Bienova, M. ; Kral, M. ; Bouchal, J. ; Trtkova, K.S. ; Burdova, A. ; Student, V. ; Kolar, Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4338-d7a11ed0d8fcd236f6938115c165a1824ef76f539f7ea36c3326dd5813037d183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alleles</topic><topic>Alopecia - blood</topic><topic>Alopecia - complications</topic><topic>Alopecia - genetics</topic><topic>Carcinoma - blood</topic><topic>Carcinoma - complications</topic><topic>Carcinoma - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prostate-Specific Antigen - blood</topic><topic>Prostatic Hyperplasia - blood</topic><topic>Prostatic Hyperplasia - complications</topic><topic>Prostatic Hyperplasia - genetics</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - complications</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Receptors, Androgen - genetics</topic><topic>Severity of Illness Index</topic><topic>Testosterone - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kucerova, R.</creatorcontrib><creatorcontrib>Bienova, M.</creatorcontrib><creatorcontrib>Kral, M.</creatorcontrib><creatorcontrib>Bouchal, J.</creatorcontrib><creatorcontrib>Trtkova, K.S.</creatorcontrib><creatorcontrib>Burdova, A.</creatorcontrib><creatorcontrib>Student, V.</creatorcontrib><creatorcontrib>Kolar, Z.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kucerova, R.</au><au>Bienova, M.</au><au>Kral, M.</au><au>Bouchal, J.</au><au>Trtkova, K.S.</au><au>Burdova, A.</au><au>Student, V.</au><au>Kolar, Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2015-01</date><risdate>2015</risdate><volume>29</volume><issue>1</issue><spage>91</spage><epage>96</epage><pages>91-96</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background
Both androgenetic alopecia (AGA) and carcinoma of the prostate (CaP) or benign prostatic hyperplasia (BPH) are androgen‐dependent disorders.
Objective
To investigate the relationships between male androgenetic alopecia, androgen receptor (AR) gene polymorphism (SNP rs6152) and clinical characteristics of BPH and prostate cancer.
Methods
Overall, 309 male subjects with prostate disease (BPH or CaP) were examined. We evaluated the standard grades of AGA (I–VII) by Hamilton–Norwood classification and 195 patients were also assessed by phototrichogram. Prostate‐specific antigen (PSA) and testosterone levels were also measured. Polymorphism rs6152 of the AR was evaluated from blood samples by PCR‐RFLP. Data were statistically evaluated.
Results
The expected positive correlation between age and AGA grade and the expected negative correlation between hair density and age and between anagen/telogen and AGA were found. A statistically significant difference between patients with A and G alleles in terms of AGA grade was found. The predominant G allele was more frequent in patients with higher grade of alopecia and in patients with significantly higher PSA. There was no correlation between diagnosis (BPH or CaP) and polymorphism. Patients with prostate inflammation had a statistically significant higher grade of AGA, together with higher PSA.
Conclusions
We confirmed that the AR gene polymorphism (SNP rs6152 G>A) is associated with the development of AGA and higher PSA levels in patients with BPH but not cancer. A novel finding of our study is that BPH patients with prostate inflammation had a significantly higher grade of AGA together with significantly higher PSA levels.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>24665929</pmid><doi>10.1111/jdv.12468</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of the European Academy of Dermatology and Venereology, 2015-01, Vol.29 (1), p.91-96 |
| issn | 0926-9959 1468-3083 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Aged, 80 and over Alleles Alopecia - blood Alopecia - complications Alopecia - genetics Carcinoma - blood Carcinoma - complications Carcinoma - genetics Humans Male Middle Aged Polymorphism, Single Nucleotide Prostate-Specific Antigen - blood Prostatic Hyperplasia - blood Prostatic Hyperplasia - complications Prostatic Hyperplasia - genetics Prostatic Neoplasms - blood Prostatic Neoplasms - complications Prostatic Neoplasms - genetics Receptors, Androgen - genetics Severity of Illness Index Testosterone - blood |
| title | Androgenetic alopecia and polymorphism of the androgen receptor gene (SNP rs6152) in patients with benign prostate hyperplasia or prostate cancer |
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