Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution
Background Head and neck soft tissue sarcomas (HNSTS) are rare tumors with various histological types displaying different clinical behavior. As a result, prognostic factors of this disease remain unclear. The aim of this study was to investigate the prognostic factors and oncological outcomes of HN...
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| Veröffentlicht in: | Annals of surgical oncology 2015-01, Vol.22 (1), p.248-255 |
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| creator | Park, Jin Taek Roh, Jong-Lyel Kim, Seon-Ok Cho, Kyung-Ja Choi, Seung-Ho Nam, Soon Yuhl Kim, Sang Yoon |
| description | Background
Head and neck soft tissue sarcomas (HNSTS) are rare tumors with various histological types displaying different clinical behavior. As a result, prognostic factors of this disease remain unclear. The aim of this study was to investigate the prognostic factors and oncological outcomes of HNSTS.
Materials and Methods
This retrospective study included 122 patients with HNSTS who were treated at our institution between 1995 and 2012. Univariate and multivariate analyses using the Cox proportional hazards model were used to determine clinicopathologic characteristics associated with locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS).
Results
Rhabdomyosarcoma was the most common tumor type (20 %), followed by dermatofibrosarcoma protuberance (13 %) and angiosarcoma (12 %). In a follow-up of 72 months, the 5-year LRC, DSS, and OS rates were 76, 77, and 75 %, respectively. Univariate analyses showed that age (>60 years), tumor size (>10 cm), nodal metastasis, and overall stage were significant prognostic factors for LRC, DSS, and OS (
p
|
| doi_str_mv | 10.1245/s10434-014-3870-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1639977282</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1639977282</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-45058badee6c634dbc12d87237522d3b3975cba9706ac2269b88a4e059abee5a3</originalsourceid><addsrcrecordid>eNp1kU2LFDEQhoMo7rr6A7xIwIuX1nx3cpTF_YDFWZjxHKrTNUOvPcmapA978L-b2VlFBE9VVJ56K_AQ8pazj1wo_alwpqTqGFedtD3r7DNyynWbKGP589YzYzsnjD4hr0q5Y4z3kumX5ETo1jMnT8nP25x2MZU6BXoBoaZcKMSRrmJIc9pNAWa6WmpIeyw0bSkXgl4hjI_QVwzf6TptK91MpSxI15AbCfQW6oSxFrrJCBUbXSnQ9RR3M9Lr2K7VpU4pviYvtjAXfPNUz8i3iy-b86vuZnV5ff75pgtKidopzbQdYEQ0wUg1DoGL0fZC9lqIUQ7S9ToM4HpmIAhh3GAtKGTawYCoQZ6RD8fc-5x-LFiq308l4DxDxLQUz410ru-FFQ19_w96l5Yc2-8OlLXaOMUbxY9UyKmUjFt_n6c95AfPmT-48Uc3vrnxBzfetp13T8nLsMfxz8ZvGQ0QR6C0p7jD_Nfp_6b-Ao3hmN4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1638856941</pqid></control><display><type>article</type><title>Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Park, Jin Taek ; Roh, Jong-Lyel ; Kim, Seon-Ok ; Cho, Kyung-Ja ; Choi, Seung-Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</creator><creatorcontrib>Park, Jin Taek ; Roh, Jong-Lyel ; Kim, Seon-Ok ; Cho, Kyung-Ja ; Choi, Seung-Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</creatorcontrib><description>Background
Head and neck soft tissue sarcomas (HNSTS) are rare tumors with various histological types displaying different clinical behavior. As a result, prognostic factors of this disease remain unclear. The aim of this study was to investigate the prognostic factors and oncological outcomes of HNSTS.
Materials and Methods
This retrospective study included 122 patients with HNSTS who were treated at our institution between 1995 and 2012. Univariate and multivariate analyses using the Cox proportional hazards model were used to determine clinicopathologic characteristics associated with locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS).
Results
Rhabdomyosarcoma was the most common tumor type (20 %), followed by dermatofibrosarcoma protuberance (13 %) and angiosarcoma (12 %). In a follow-up of 72 months, the 5-year LRC, DSS, and OS rates were 76, 77, and 75 %, respectively. Univariate analyses showed that age (>60 years), tumor size (>10 cm), nodal metastasis, and overall stage were significant prognostic factors for LRC, DSS, and OS (
p
< 0.05). Histological grade was also significantly associated with DSS (
p
= 0.012) and OS (
p
= 0.002). In multivariate analysis, tumor size and nodal metastasis were independent prognostic factors for LRC (
p
< 0.05), while age, histological grade, and nodal metastasis remained independent variables for both DSS and OS (
p
< 0.05).
Conclusions
Our data support that surgical excision of HNSTS contributes to acceptable survival rates. Several factors at diagnosis may be independently associated with recurrence and survival outcomes, and identification of these factors may help in selecting at-risk patients.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-014-3870-8</identifier><identifier>PMID: 25001093</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Bone and Soft Tissue Sarcomas ; Combined Modality Therapy ; Female ; Follow-Up Studies ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; Humans ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - therapy ; Neoplasm Staging ; Oncology ; Prognosis ; Retrospective Studies ; Sarcoma - mortality ; Sarcoma - pathology ; Sarcoma - therapy ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2015-01, Vol.22 (1), p.248-255</ispartof><rights>Society of Surgical Oncology 2014</rights><rights>Society of Surgical Oncology 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-45058badee6c634dbc12d87237522d3b3975cba9706ac2269b88a4e059abee5a3</citedby><cites>FETCH-LOGICAL-c442t-45058badee6c634dbc12d87237522d3b3975cba9706ac2269b88a4e059abee5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-014-3870-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-014-3870-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41466,42535,51296</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25001093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Park, Jin Taek</creatorcontrib><creatorcontrib>Roh, Jong-Lyel</creatorcontrib><creatorcontrib>Kim, Seon-Ok</creatorcontrib><creatorcontrib>Cho, Kyung-Ja</creatorcontrib><creatorcontrib>Choi, Seung-Ho</creatorcontrib><creatorcontrib>Nam, Soon Yuhl</creatorcontrib><creatorcontrib>Kim, Sang Yoon</creatorcontrib><title>Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Head and neck soft tissue sarcomas (HNSTS) are rare tumors with various histological types displaying different clinical behavior. As a result, prognostic factors of this disease remain unclear. The aim of this study was to investigate the prognostic factors and oncological outcomes of HNSTS.
Materials and Methods
This retrospective study included 122 patients with HNSTS who were treated at our institution between 1995 and 2012. Univariate and multivariate analyses using the Cox proportional hazards model were used to determine clinicopathologic characteristics associated with locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS).
Results
Rhabdomyosarcoma was the most common tumor type (20 %), followed by dermatofibrosarcoma protuberance (13 %) and angiosarcoma (12 %). In a follow-up of 72 months, the 5-year LRC, DSS, and OS rates were 76, 77, and 75 %, respectively. Univariate analyses showed that age (>60 years), tumor size (>10 cm), nodal metastasis, and overall stage were significant prognostic factors for LRC, DSS, and OS (
p
< 0.05). Histological grade was also significantly associated with DSS (
p
= 0.012) and OS (
p
= 0.002). In multivariate analysis, tumor size and nodal metastasis were independent prognostic factors for LRC (
p
< 0.05), while age, histological grade, and nodal metastasis remained independent variables for both DSS and OS (
p
< 0.05).
Conclusions
Our data support that surgical excision of HNSTS contributes to acceptable survival rates. Several factors at diagnosis may be independently associated with recurrence and survival outcomes, and identification of these factors may help in selecting at-risk patients.</description><subject>Adult</subject><subject>Bone and Soft Tissue Sarcomas</subject><subject>Combined Modality Therapy</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - therapy</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Sarcoma - mortality</subject><subject>Sarcoma - pathology</subject><subject>Sarcoma - therapy</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU2LFDEQhoMo7rr6A7xIwIuX1nx3cpTF_YDFWZjxHKrTNUOvPcmapA978L-b2VlFBE9VVJ56K_AQ8pazj1wo_alwpqTqGFedtD3r7DNyynWbKGP589YzYzsnjD4hr0q5Y4z3kumX5ETo1jMnT8nP25x2MZU6BXoBoaZcKMSRrmJIc9pNAWa6WmpIeyw0bSkXgl4hjI_QVwzf6TptK91MpSxI15AbCfQW6oSxFrrJCBUbXSnQ9RR3M9Lr2K7VpU4pviYvtjAXfPNUz8i3iy-b86vuZnV5ff75pgtKidopzbQdYEQ0wUg1DoGL0fZC9lqIUQ7S9ToM4HpmIAhh3GAtKGTawYCoQZ6RD8fc-5x-LFiq308l4DxDxLQUz410ru-FFQ19_w96l5Yc2-8OlLXaOMUbxY9UyKmUjFt_n6c95AfPmT-48Uc3vrnxBzfetp13T8nLsMfxz8ZvGQ0QR6C0p7jD_Nfp_6b-Ao3hmN4</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Park, Jin Taek</creator><creator>Roh, Jong-Lyel</creator><creator>Kim, Seon-Ok</creator><creator>Cho, Kyung-Ja</creator><creator>Choi, Seung-Ho</creator><creator>Nam, Soon Yuhl</creator><creator>Kim, Sang Yoon</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20150101</creationdate><title>Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution</title><author>Park, Jin Taek ; Roh, Jong-Lyel ; Kim, Seon-Ok ; Cho, Kyung-Ja ; Choi, Seung-Ho ; Nam, Soon Yuhl ; Kim, Sang Yoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-45058badee6c634dbc12d87237522d3b3975cba9706ac2269b88a4e059abee5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Bone and Soft Tissue Sarcomas</topic><topic>Combined Modality Therapy</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - therapy</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Sarcoma - mortality</topic><topic>Sarcoma - pathology</topic><topic>Sarcoma - therapy</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Park, Jin Taek</creatorcontrib><creatorcontrib>Roh, Jong-Lyel</creatorcontrib><creatorcontrib>Kim, Seon-Ok</creatorcontrib><creatorcontrib>Cho, Kyung-Ja</creatorcontrib><creatorcontrib>Choi, Seung-Ho</creatorcontrib><creatorcontrib>Nam, Soon Yuhl</creatorcontrib><creatorcontrib>Kim, Sang Yoon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Park, Jin Taek</au><au>Roh, Jong-Lyel</au><au>Kim, Seon-Ok</au><au>Cho, Kyung-Ja</au><au>Choi, Seung-Ho</au><au>Nam, Soon Yuhl</au><au>Kim, Sang Yoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>22</volume><issue>1</issue><spage>248</spage><epage>255</epage><pages>248-255</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Head and neck soft tissue sarcomas (HNSTS) are rare tumors with various histological types displaying different clinical behavior. As a result, prognostic factors of this disease remain unclear. The aim of this study was to investigate the prognostic factors and oncological outcomes of HNSTS.
Materials and Methods
This retrospective study included 122 patients with HNSTS who were treated at our institution between 1995 and 2012. Univariate and multivariate analyses using the Cox proportional hazards model were used to determine clinicopathologic characteristics associated with locoregional control (LRC), disease-specific survival (DSS), and overall survival (OS).
Results
Rhabdomyosarcoma was the most common tumor type (20 %), followed by dermatofibrosarcoma protuberance (13 %) and angiosarcoma (12 %). In a follow-up of 72 months, the 5-year LRC, DSS, and OS rates were 76, 77, and 75 %, respectively. Univariate analyses showed that age (>60 years), tumor size (>10 cm), nodal metastasis, and overall stage were significant prognostic factors for LRC, DSS, and OS (
p
< 0.05). Histological grade was also significantly associated with DSS (
p
= 0.012) and OS (
p
= 0.002). In multivariate analysis, tumor size and nodal metastasis were independent prognostic factors for LRC (
p
< 0.05), while age, histological grade, and nodal metastasis remained independent variables for both DSS and OS (
p
< 0.05).
Conclusions
Our data support that surgical excision of HNSTS contributes to acceptable survival rates. Several factors at diagnosis may be independently associated with recurrence and survival outcomes, and identification of these factors may help in selecting at-risk patients.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>25001093</pmid><doi>10.1245/s10434-014-3870-8</doi><tpages>8</tpages></addata></record> |
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| ispartof | Annals of surgical oncology, 2015-01, Vol.22 (1), p.248-255 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Bone and Soft Tissue Sarcomas Combined Modality Therapy Female Follow-Up Studies Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neoplasm Grading Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - therapy Neoplasm Staging Oncology Prognosis Retrospective Studies Sarcoma - mortality Sarcoma - pathology Sarcoma - therapy Surgery Surgical Oncology Survival Rate |
| title | Prognostic Factors and Oncological Outcomes of 122 Head and Neck Soft Tissue Sarcoma Patients Treated at a Single Institution |
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