Chronic NO synthase inhibition fails to protect hippocampal neurones against NMDA toxicity

SINCE nitric oxide (NO) is supposed to mediate excitotoxicity in various brain structures, the effects of two NO synthase inhibitors were studied on rat hippocampal lesions induced by the focal injection of N-methyl-D-aspartate (NMDA). Although both drugs (N-nitro-L-arginine methyl esterL-NAME and L...

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Veröffentlicht in:	Neuroreport 1992-12, Vol.3 (12), p.1109-1112
Hauptverfasser:	Lerner-Natoli, Mireille, Rondouin, Gérard, de Bock, Frédéric, Bockaert, Joël
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Oxidoreductases - antagonists & inhibitors Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Hippocampus - cytology Hippocampus - drug effects Medical sciences Miscellaneous N-Methylaspartate - antagonists & inhibitors N-Methylaspartate - toxicity Neurons - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors NG-Nitroarginine Methyl Ester Nitric Oxide - metabolism Nitric Oxide Synthase Nitroarginine Pharmacology. Drug treatments Rats
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