Action of ciguatoxin on human atrial trabeculae
This report describes the action of ciguatoxin-1, the major ciguatoxin present in fishes that cause ciguatera, on the contractile activity of human cardiac musculature. Ciguatoxin-1 caused a large, sustained and concentration-dependent positive inotropy in human atrial trabeculae that were obtained...
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| Veröffentlicht in: | Toxicon (Oxford) 1992-08, Vol.30 (8), p.907-914 |
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| creator | Lewis, Richard J. Wong Hoy, Ashley W. McGiffin, David C. |
| description | This report describes the action of ciguatoxin-1, the major ciguatoxin present in fishes that cause ciguatera, on the contractile activity of human cardiac musculature. Ciguatoxin-1 caused a large, sustained and concentration-dependent positive inotropy in human atrial trabeculae that were obtained during coronary artery bypass surgery from otherwise healthy hearts. Atenolol (a
β
1-adrenoceptor selective antagonist without local anaesthetic-type activity) or low concentrations of tetrodotoxin abolished the positive inotropy caused by ciguatoxin-1, indicating that ciguatoxin-1 stimulated neural elements present in this tissue to release noradrenaline. The positive inotropic action of ciguatoxin-1 did not stem from a significant direct action on myocardial voltage-dependent sodium channels, nor did it stem from significant
α
1- or
β
2-adrenoreceptor stimulation. Ciguatoxin-1 caused positive inotropy in preparations stimulated at between 0.02 and 2.0 Hz. Mannitol, currently the treatment of choice for ciguatera, did not significantly reverse the positive inotropy induced by ciguatoxin-1 in human atrial trabeculae. |
| doi_str_mv | 10.1016/0041-0101(92)90389-M |
| format | Article |
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β
1-adrenoceptor selective antagonist without local anaesthetic-type activity) or low concentrations of tetrodotoxin abolished the positive inotropy caused by ciguatoxin-1, indicating that ciguatoxin-1 stimulated neural elements present in this tissue to release noradrenaline. The positive inotropic action of ciguatoxin-1 did not stem from a significant direct action on myocardial voltage-dependent sodium channels, nor did it stem from significant
α
1- or
β
2-adrenoreceptor stimulation. Ciguatoxin-1 caused positive inotropy in preparations stimulated at between 0.02 and 2.0 Hz. Mannitol, currently the treatment of choice for ciguatera, did not significantly reverse the positive inotropy induced by ciguatoxin-1 in human atrial trabeculae.</description><identifier>ISSN: 0041-0101</identifier><identifier>EISSN: 1879-3150</identifier><identifier>DOI: 10.1016/0041-0101(92)90389-M</identifier><identifier>PMID: 1523682</identifier><identifier>CODEN: TOXIA6</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Adult ; Aged ; atrium ; Biological and medical sciences ; Ciguatoxins - toxicity ; dinophyta ; Female ; Heart - drug effects ; Heart - physiology ; Heart Atria - drug effects ; Humans ; ichthyotoxins ; Male ; Mannitol - pharmacology ; Marine ; Medical sciences ; Middle Aged ; muscle contraction ; Muscle Contraction - drug effects ; Muscle Contraction - physiology ; myocardium ; norepinephrine ; Plant poisons toxicology ; release ; toxicity ; Toxicology</subject><ispartof>Toxicon (Oxford), 1992-08, Vol.30 (8), p.907-914</ispartof><rights>1992</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-f624aae95eed7be7e783dcbe98ec82cc0cf75f1e816ff92023c1c5f34bc2ba343</citedby><cites>FETCH-LOGICAL-c441t-f624aae95eed7be7e783dcbe98ec82cc0cf75f1e816ff92023c1c5f34bc2ba343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0041-0101(92)90389-M$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5424426$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1523682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lewis, Richard J.</creatorcontrib><creatorcontrib>Wong Hoy, Ashley W.</creatorcontrib><creatorcontrib>McGiffin, David C.</creatorcontrib><title>Action of ciguatoxin on human atrial trabeculae</title><title>Toxicon (Oxford)</title><addtitle>Toxicon</addtitle><description>This report describes the action of ciguatoxin-1, the major ciguatoxin present in fishes that cause ciguatera, on the contractile activity of human cardiac musculature. Ciguatoxin-1 caused a large, sustained and concentration-dependent positive inotropy in human atrial trabeculae that were obtained during coronary artery bypass surgery from otherwise healthy hearts. Atenolol (a
β
1-adrenoceptor selective antagonist without local anaesthetic-type activity) or low concentrations of tetrodotoxin abolished the positive inotropy caused by ciguatoxin-1, indicating that ciguatoxin-1 stimulated neural elements present in this tissue to release noradrenaline. The positive inotropic action of ciguatoxin-1 did not stem from a significant direct action on myocardial voltage-dependent sodium channels, nor did it stem from significant
α
1- or
β
2-adrenoreceptor stimulation. Ciguatoxin-1 caused positive inotropy in preparations stimulated at between 0.02 and 2.0 Hz. Mannitol, currently the treatment of choice for ciguatera, did not significantly reverse the positive inotropy induced by ciguatoxin-1 in human atrial trabeculae.</description><subject>Adult</subject><subject>Aged</subject><subject>atrium</subject><subject>Biological and medical sciences</subject><subject>Ciguatoxins - toxicity</subject><subject>dinophyta</subject><subject>Female</subject><subject>Heart - drug effects</subject><subject>Heart - physiology</subject><subject>Heart Atria - drug effects</subject><subject>Humans</subject><subject>ichthyotoxins</subject><subject>Male</subject><subject>Mannitol - pharmacology</subject><subject>Marine</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>muscle contraction</subject><subject>Muscle Contraction - drug effects</subject><subject>Muscle Contraction - physiology</subject><subject>myocardium</subject><subject>norepinephrine</subject><subject>Plant poisons toxicology</subject><subject>release</subject><subject>toxicity</subject><subject>Toxicology</subject><issn>0041-0101</issn><issn>1879-3150</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhq0K1C5b_kFRc0AIDmn9lcS-IFUrvqStOEDP1mQyLq6yyWInCP49XrJqb5xmRvPM6NXD2IXgV4KL-ppzLUqe27dWvrNcGVvenrCVMI0tlaj4M7Z6RM7Yi5QeOD9Q9Sk7FZVUtZErdn2DUxiHYvQFhvsZpvF3yNNQ_Jh3MBQwxQB9MUVoCece6Jw999Anenmsa3b38cP3zedy-_XTl83NtkStxVT6WmoAshVR17TUUGNUhy1ZQ2gkIkffVF6QEbX3VnKpUGDllW5RtqC0WrM3y999HH_OlCa3Cwmp72GgcU5O1MoazUUG9QJiHFOK5N0-hh3EP05wd_DkDhLcQYKz0v3z5G7z2avj_7ndUfd0tIjJ-9fHPSSE3kcYMKRHrNJSa1ln7HLBPIwO7mNG7r7JHIuLxgheN5l4vxCUbf0KFF3CQANSFyLh5Lox_D_pXxc9jJc</recordid><startdate>19920801</startdate><enddate>19920801</enddate><creator>Lewis, Richard J.</creator><creator>Wong Hoy, Ashley W.</creator><creator>McGiffin, David C.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>H97</scope><scope>H99</scope><scope>L.F</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>19920801</creationdate><title>Action of ciguatoxin on human atrial trabeculae</title><author>Lewis, Richard J. ; Wong Hoy, Ashley W. ; McGiffin, David C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-f624aae95eed7be7e783dcbe98ec82cc0cf75f1e816ff92023c1c5f34bc2ba343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Adult</topic><topic>Aged</topic><topic>atrium</topic><topic>Biological and medical sciences</topic><topic>Ciguatoxins - toxicity</topic><topic>dinophyta</topic><topic>Female</topic><topic>Heart - drug effects</topic><topic>Heart - physiology</topic><topic>Heart Atria - drug effects</topic><topic>Humans</topic><topic>ichthyotoxins</topic><topic>Male</topic><topic>Mannitol - pharmacology</topic><topic>Marine</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>muscle contraction</topic><topic>Muscle Contraction - drug effects</topic><topic>Muscle Contraction - physiology</topic><topic>myocardium</topic><topic>norepinephrine</topic><topic>Plant poisons toxicology</topic><topic>release</topic><topic>toxicity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lewis, Richard J.</creatorcontrib><creatorcontrib>Wong Hoy, Ashley W.</creatorcontrib><creatorcontrib>McGiffin, David C.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ASFA: Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Marine Biotechnology Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Toxicon (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lewis, Richard J.</au><au>Wong Hoy, Ashley W.</au><au>McGiffin, David C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Action of ciguatoxin on human atrial trabeculae</atitle><jtitle>Toxicon (Oxford)</jtitle><addtitle>Toxicon</addtitle><date>1992-08-01</date><risdate>1992</risdate><volume>30</volume><issue>8</issue><spage>907</spage><epage>914</epage><pages>907-914</pages><issn>0041-0101</issn><eissn>1879-3150</eissn><coden>TOXIA6</coden><abstract>This report describes the action of ciguatoxin-1, the major ciguatoxin present in fishes that cause ciguatera, on the contractile activity of human cardiac musculature. Ciguatoxin-1 caused a large, sustained and concentration-dependent positive inotropy in human atrial trabeculae that were obtained during coronary artery bypass surgery from otherwise healthy hearts. Atenolol (a
β
1-adrenoceptor selective antagonist without local anaesthetic-type activity) or low concentrations of tetrodotoxin abolished the positive inotropy caused by ciguatoxin-1, indicating that ciguatoxin-1 stimulated neural elements present in this tissue to release noradrenaline. The positive inotropic action of ciguatoxin-1 did not stem from a significant direct action on myocardial voltage-dependent sodium channels, nor did it stem from significant
α
1- or
β
2-adrenoreceptor stimulation. Ciguatoxin-1 caused positive inotropy in preparations stimulated at between 0.02 and 2.0 Hz. Mannitol, currently the treatment of choice for ciguatera, did not significantly reverse the positive inotropy induced by ciguatoxin-1 in human atrial trabeculae.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>1523682</pmid><doi>10.1016/0041-0101(92)90389-M</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged atrium Biological and medical sciences Ciguatoxins - toxicity dinophyta Female Heart - drug effects Heart - physiology Heart Atria - drug effects Humans ichthyotoxins Male Mannitol - pharmacology Marine Medical sciences Middle Aged muscle contraction Muscle Contraction - drug effects Muscle Contraction - physiology myocardium norepinephrine Plant poisons toxicology release toxicity Toxicology |
| title | Action of ciguatoxin on human atrial trabeculae |
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