Antiparkinsonian drugs memantine and trihexyphenidyl potentiate the anticonvulsant activity of valproate against maximal electroshock-induced seizures

Memantine increased the threshold for electroconvulsions, when administered at 1.0–6.0 mg/kg (i.p.) and given in subthreshold dosesof 0.0156, 0.0625, 0.125 and 0.5 mg/kg (i.p.) potentiated the protective efficacy of valproate, against maximal electroshock (50 mA)-induced seizures in mice, lowering t...

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Veröffentlicht in:	Neuropharmacology 1992-10, Vol.31 (10), p.1021-1026
Hauptverfasser:	Urbańska, E., Dziki, M., Czuczwar, S.J., Kleinrok, Z., Turski, W.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Anticonvulsants. Antiepileptics. Antiparkinson agents Antiparkinson Agents - pharmacology Avoidance Learning - drug effects Biological and medical sciences Drug Synergism Electroshock Male Medical sciences memantine Memantine - pharmacology Memory - drug effects Mice Neuropharmacology Pharmacology. Drug treatments Psychomotor Performance - drug effects seizures Seizures - prevention & control trihexyphenidyl Trihexyphenidyl - pharmacology valproate Valproic Acid - pharmacology
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