Magnetic resonance-guided focused ultrasound surgery (MRgFUS) of uterine fibroids in Singapore
Uterine fibroids are the most common type of gynaecologic benign tumours, occurring in 25% to 50% of women during their reproductive lives. About half of the affected women have clinically significant symptoms, including abnormal bleeding, menstrual pain, frequent urination, constipation and abdomin...
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| Veröffentlicht in: | Annals of the Academy of Medicine, Singapore Singapore, 2014-11, Vol.43 (11), p.550-558 |
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| creator | Han, Nian-Lin R Ong, Chiou Li |
| description | Uterine fibroids are the most common type of gynaecologic benign tumours, occurring in 25% to 50% of women during their reproductive lives. About half of the affected women have clinically significant symptoms, including abnormal bleeding, menstrual pain, frequent urination, constipation and abdominal distension. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) has been used to treat patients with benign lesions and a variety of malignancies. The objective of this study is to evaluate symptom relief before and after MR-guided ultrasound ablation of fibroids.
A total of 37 patients with symptomatic uterine fibroids were treated in this study.
MRgFUS treatment led to a significant, time-dependent decrease in not only Symptom Severity Scores (SSS), but also the mean fibroid volume. The average reductions in volume were 41.6% and 52.6% at 6 months and 12 months respectively (P |
| doi_str_mv | 10.47102/annals-acadmedsg.V43N11p550 |
| format | Article |
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A total of 37 patients with symptomatic uterine fibroids were treated in this study.
MRgFUS treatment led to a significant, time-dependent decrease in not only Symptom Severity Scores (SSS), but also the mean fibroid volume. The average reductions in volume were 41.6% and 52.6% at 6 months and 12 months respectively (P <0.05). The mean SSS of the 37 patients was 41.7 ± 2.8 before treatment whereas the average SSS was 26.9 ± 3.6, 20.7 ± 3.4, 18.5 ± 3.6, 16.5 ± 7.1, 9.8 ± 3.6 at 3 months, 6 months, 1 year, 2 years, and 3 to 4 years respectively. The decrease in scores was significant at all time points up to 3 to 4 years (P <0.05 and P <0.001).
MRgFUS is a safe and effective non-invasive treatment for patients with symptomatic fibroids.</description><identifier>ISSN: 0304-4602</identifier><identifier>EISSN: 0304-4602</identifier><identifier>DOI: 10.47102/annals-acadmedsg.V43N11p550</identifier><identifier>PMID: 25523859</identifier><language>eng</language><publisher>Singapore</publisher><subject>Adult ; Female ; Humans ; Leiomyoma - diagnosis ; Leiomyoma - surgery ; Magnetic Resonance Imaging ; Middle Aged ; Prospective Studies ; Singapore ; Surgery, Computer-Assisted ; Treatment Outcome ; Ultrasonography, Interventional ; Uterine Neoplasms - diagnosis ; Uterine Neoplasms - surgery</subject><ispartof>Annals of the Academy of Medicine, Singapore, 2014-11, Vol.43 (11), p.550-558</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-ec7e116e041bee011bad6edcad99206a12c12441e9b9e41dd53cee374ffc520b3</citedby><cites>FETCH-LOGICAL-c447t-ec7e116e041bee011bad6edcad99206a12c12441e9b9e41dd53cee374ffc520b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25523859$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, Nian-Lin R</creatorcontrib><creatorcontrib>Ong, Chiou Li</creatorcontrib><title>Magnetic resonance-guided focused ultrasound surgery (MRgFUS) of uterine fibroids in Singapore</title><title>Annals of the Academy of Medicine, Singapore</title><addtitle>Ann Acad Med Singapore</addtitle><description>Uterine fibroids are the most common type of gynaecologic benign tumours, occurring in 25% to 50% of women during their reproductive lives. About half of the affected women have clinically significant symptoms, including abnormal bleeding, menstrual pain, frequent urination, constipation and abdominal distension. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) has been used to treat patients with benign lesions and a variety of malignancies. The objective of this study is to evaluate symptom relief before and after MR-guided ultrasound ablation of fibroids.
A total of 37 patients with symptomatic uterine fibroids were treated in this study.
MRgFUS treatment led to a significant, time-dependent decrease in not only Symptom Severity Scores (SSS), but also the mean fibroid volume. The average reductions in volume were 41.6% and 52.6% at 6 months and 12 months respectively (P <0.05). The mean SSS of the 37 patients was 41.7 ± 2.8 before treatment whereas the average SSS was 26.9 ± 3.6, 20.7 ± 3.4, 18.5 ± 3.6, 16.5 ± 7.1, 9.8 ± 3.6 at 3 months, 6 months, 1 year, 2 years, and 3 to 4 years respectively. The decrease in scores was significant at all time points up to 3 to 4 years (P <0.05 and P <0.001).
MRgFUS is a safe and effective non-invasive treatment for patients with symptomatic fibroids.</description><subject>Adult</subject><subject>Female</subject><subject>Humans</subject><subject>Leiomyoma - diagnosis</subject><subject>Leiomyoma - surgery</subject><subject>Magnetic Resonance Imaging</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Singapore</subject><subject>Surgery, Computer-Assisted</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Interventional</subject><subject>Uterine Neoplasms - diagnosis</subject><subject>Uterine Neoplasms - surgery</subject><issn>0304-4602</issn><issn>0304-4602</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1OwzAQhC0EoqXwCsgHDuUQsB0nwRIXVFFAakGilCORY28io9Qudnzo2xPRUjjNSjuzPx9CF5Rc8YISdi2tlW1IpJJ6BTo0V-88faZ0nWXkAA1JSnjCc8IO_9UDdBLCJyG8ICw_RgOWZSy9ycQQfcxlY6EzCnsIzkqrIGmi0aBx7VQMvca28zK4aDUO0TfgN3g8f22my8UldjWOHXhjAdem8s7ogI3FC2MbuXYeTtFR3R8LZzsdoeX0_m3ymMxeHp4md7NEcV50CagCKM2BcFoBEEorqXPQ_YdCMJJLyhRlnFMQlQBOtc5SBZAWvK5VxkiVjtB4O3ft3VeE0JUrExS0rbTgYihpngouRFaw3nq7tSrvQvBQl2tvVtJvSkrKH8LllnC5J1z-Ee7j57tNseqb-_Av0vQbRpx_AQ</recordid><startdate>20141101</startdate><enddate>20141101</enddate><creator>Han, Nian-Lin R</creator><creator>Ong, Chiou Li</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20141101</creationdate><title>Magnetic resonance-guided focused ultrasound surgery (MRgFUS) of uterine fibroids in Singapore</title><author>Han, Nian-Lin R ; Ong, Chiou Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-ec7e116e041bee011bad6edcad99206a12c12441e9b9e41dd53cee374ffc520b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Female</topic><topic>Humans</topic><topic>Leiomyoma - diagnosis</topic><topic>Leiomyoma - surgery</topic><topic>Magnetic Resonance Imaging</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Singapore</topic><topic>Surgery, Computer-Assisted</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Interventional</topic><topic>Uterine Neoplasms - diagnosis</topic><topic>Uterine Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Nian-Lin R</creatorcontrib><creatorcontrib>Ong, Chiou Li</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the Academy of Medicine, Singapore</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Nian-Lin R</au><au>Ong, Chiou Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance-guided focused ultrasound surgery (MRgFUS) of uterine fibroids in Singapore</atitle><jtitle>Annals of the Academy of Medicine, Singapore</jtitle><addtitle>Ann Acad Med Singapore</addtitle><date>2014-11-01</date><risdate>2014</risdate><volume>43</volume><issue>11</issue><spage>550</spage><epage>558</epage><pages>550-558</pages><issn>0304-4602</issn><eissn>0304-4602</eissn><abstract>Uterine fibroids are the most common type of gynaecologic benign tumours, occurring in 25% to 50% of women during their reproductive lives. About half of the affected women have clinically significant symptoms, including abnormal bleeding, menstrual pain, frequent urination, constipation and abdominal distension. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) has been used to treat patients with benign lesions and a variety of malignancies. The objective of this study is to evaluate symptom relief before and after MR-guided ultrasound ablation of fibroids.
A total of 37 patients with symptomatic uterine fibroids were treated in this study.
MRgFUS treatment led to a significant, time-dependent decrease in not only Symptom Severity Scores (SSS), but also the mean fibroid volume. The average reductions in volume were 41.6% and 52.6% at 6 months and 12 months respectively (P <0.05). The mean SSS of the 37 patients was 41.7 ± 2.8 before treatment whereas the average SSS was 26.9 ± 3.6, 20.7 ± 3.4, 18.5 ± 3.6, 16.5 ± 7.1, 9.8 ± 3.6 at 3 months, 6 months, 1 year, 2 years, and 3 to 4 years respectively. The decrease in scores was significant at all time points up to 3 to 4 years (P <0.05 and P <0.001).
MRgFUS is a safe and effective non-invasive treatment for patients with symptomatic fibroids.</abstract><cop>Singapore</cop><pmid>25523859</pmid><doi>10.47102/annals-acadmedsg.V43N11p550</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Female Humans Leiomyoma - diagnosis Leiomyoma - surgery Magnetic Resonance Imaging Middle Aged Prospective Studies Singapore Surgery, Computer-Assisted Treatment Outcome Ultrasonography, Interventional Uterine Neoplasms - diagnosis Uterine Neoplasms - surgery |
| title | Magnetic resonance-guided focused ultrasound surgery (MRgFUS) of uterine fibroids in Singapore |
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