An AUTS2–Polycomb complex activates gene expression in the CNS

Naturally occurring variations of Polycomb repressive complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that include, surprisingly, autism susceptibility candidate 2 (AUTS2). Although AUTS2 is often disrupted in patients with neuronal disorders, the mechanis...

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Veröffentlicht in:	Nature (London) 2014-12, Vol.516 (7531), p.349-354
Hauptverfasser:	Gao, Zhonghua, Lee, Pedro, Stafford, James M., von Schimmelmann, Melanie, Schaefer, Anne, Reinberg, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/109 13/51 13/89 38/15 38/23 38/39 38/91 42/41 45/70 631/45 64/60 82/1 82/58 82/80 82/83 Animals Autism Behavior, Animal - physiology Brain Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Central nervous system Central Nervous System - metabolism Chromatin Epigenetics Female Gene expression Gene Expression Profiling Gene Expression Regulation - genetics Gene Knockout Techniques Genetic aspects Genotype HEK293 Cells Histones - metabolism Humanities and Social Sciences Humans Kinases Male Methods Mice Mice, Inbred C57BL multidisciplinary Nervous system Phosphorylation Physiological aspects Proteins - genetics Proteins - metabolism Science Ubiquitination
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