MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells

Background & Aims Current hepatic differentiation protocols for human embryonic stem cells (ESCs) require substantial improvements. MicroRNAs (miRNAs) have been reported to regulate hepatocyte cell fate during liver development, but their utility to improve hepatocyte differentiation from ESCs r...

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Veröffentlicht in:	Journal of hepatology 2015-01, Vol.62 (1), p.101-110
Hauptverfasser:	Möbus, Selina, Yang, Dakai, Yuan, Qinggong, Lüdtke, Timo H.-W, Balakrishnan, Asha, Sgodda, Malte, Rani, Bhavna, Kispert, Andreas, Araúzo-Bravo, Marcos J, Vogel, Arndt, Manns, Michael P, Ott, Michael, Cantz, Tobias, Sharma, Amar Deep
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blotting, Western Cell Differentiation Cells, Cultured Embryonic stem cells Gastroenterology and Hepatology Gene Expression Regulation Hepatocyte differentiation Hepatocytes - cytology Hepatocytes - metabolism Human Embryonic Stem Cells - cytology Human Embryonic Stem Cells - metabolism Humans Liver repopulation Liver Transplantation Mice Mice, Knockout MicroRNA MicroRNAs - antagonists & inhibitors MicroRNAs - biosynthesis MicroRNAs - genetics Real-Time Polymerase Chain Reaction RNA - genetics
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