Synthesis and Biological Evaluation of Novel N' (4-aryloxybenzylidene)- 1H-Benzimidazole-2 Carbohydrazide Derivatives as Anti-Tubercular Agents

A series of structurally novel, (E)-N'-(4-aryloxybenzylidene)-1H-benzimidazole-2-carbohydrazide derivatives were synthesized by molecular hybridization technique. All these compounds were evaluated against Mycobacterium tuberculosis H37Rv strains using Resazurin Microtiter assay (REMA) method....

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Veröffentlicht in:	Combinatorial chemistry & high throughput screening 2014-01, Vol.17 (7), p.630-638
Hauptverfasser:	Siddiki, Afsar Ali, Bairwa, Vinod Kumar, Telvekar, Vikas N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - chemical synthesis Antitubercular Agents - chemistry Antitubercular Agents - pharmacology Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Benzimidazoles - pharmacology Humans Hydrazines - chemical synthesis Hydrazines - chemistry Hydrazines - pharmacology Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Tuberculosis - drug therapy
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